BRAIN MECHANISMS MEDIATING GENETIC RISK FACTORS FOR ANXIETY AND DEPRESSION

调节焦虑和抑郁遗传风险因素的大脑机制

• 批准号: 8173139
• 负责人: Ned H Kalin
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173139
• 关键词: Animals; Anxiety; Base of the Brain; Behavioral; Binding; Brain; Candidate Disease Gene; Computer Retrieval of Information on Scientific Projects Database; Development; Emotions; Foxes; Funding; Genetic; Genotype; Grant; Heritability; Information Services; Institution; Library Services; Mediating; Mental Depression; Positron-Emission Tomography; Printing; Publications; Research; Research Personnel; Resources; Services; Source; United States National Institutes of Health; Work; base; genetic risk factor; neuroimaging; nonhuman primate; response; serotonin transporter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate the genetic basis of brain development and mechanisms underlying anxiety and depression. Candidate genes that are likely to influence the brain's response to a behavioral challenge in order to understand the heritability of the neurocircuitry of emotion are being defined. These studies will further our understanding of the genetic bases of vulnerability to anxiety and depression. This work used WNPRC Animal Services, Operational Services, and Library and Information Services. PUBLICATION: Christian BT, Fox AS, Oler JA, Vandehey NT, Murali D, Rogers J, Oakes TR, Shelton SE, Davidson RJ, Kalin NH. (2009) Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. Neuroimage, Epub ahead of print.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：研究焦虑和抑郁症的脑发育和机制的遗传基础。 为了了解情绪神经循环的遗传力的候选基因可能会影响大脑对行为挑战的反应。 这些研究将进一步理解焦虑和抑郁症的脆弱性遗传基础。 这项工作使用了WNPRC动物服务，运营服务以及图书馆和信息服务。 发布： Christian BT，Fox AS，Oler JA，Vandehey NT，Murali D，Rogers J，Oakes TR，Shelton SE，Davidson RJ，Kalin NH。 （2009）使用[C-11] DASB PET的非人类灵长类动物大脑中的5-羟色胺转运蛋白转运蛋白结合和基因型。神经图像，epub在印刷前。