BRAIN MECHANISMS MEDIATING GENETIC RISK FACTORS FOR ANXIETY AND DEPRESSION

调节焦虑和抑郁遗传风险因素的大脑机制

• 批准号: 8173139
• 负责人: Ned H Kalin
• 金额: $ 3.1万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173139
• 关键词: Animals; Anxiety; Base of the Brain; Behavioral; Binding; Brain; Candidate Disease Gene; Computer Retrieval of Information on Scientific Projects Database; Development; Emotions; Foxes; Funding; Genetic; Genotype; Grant; Heritability; Information Services; Institution; Library Services; Mediating; Mental Depression; Positron-Emission Tomography; Printing; Publications; Research; Research Personnel; Resources; Services; Source; United States National Institutes of Health; Work; base; genetic risk factor; neuroimaging; nonhuman primate; response; serotonin transporter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To investigate the genetic basis of brain development and mechanisms underlying anxiety and depression. Candidate genes that are likely to influence the brain's response to a behavioral challenge in order to understand the heritability of the neurocircuitry of emotion are being defined. These studies will further our understanding of the genetic bases of vulnerability to anxiety and depression. This work used WNPRC Animal Services, Operational Services, and Library and Information Services. PUBLICATION: Christian BT, Fox AS, Oler JA, Vandehey NT, Murali D, Rogers J, Oakes TR, Shelton SE, Davidson RJ, Kalin NH. (2009) Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. Neuroimage, Epub ahead of print.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：探讨大脑发育的遗传基础以及焦虑和抑郁的机制。 正在定义可能影响大脑对行为挑战的反应的候选基因，以便了解情绪神经回路的遗传性。 这些研究将进一步加深我们对易患焦虑和抑郁的遗传基础的理解。 这项工作使用了 WNPRC 动物服务、运营服务以及图书馆和信息服务。 发布： 克里斯蒂安·BT、福克斯·AS、奥勒·JA、范德黑·NT、穆拉利·D、罗杰斯·J、奥克斯·TR、谢尔顿·SE、戴维森·RJ、卡林·NH。 (2009) 使用 [C-11]DASB PET 在非人类灵长类动物大脑中进行血清素转运蛋白结合和基因分型。 Neuroimage，印刷前的电子版。