EMOTIONAL PROCESSING

情绪处理

• 批准号: 8358191
• 负责人: Ned H Kalin
• 金额: $ 15.64万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358191
• 关键词: Accounting; Address; Adrenal Glands; Amygdaloid structure; Animals; Anxiety; Biological Psychiatry; Brain; Cognitive; Emotional; Emotions; Foxes; Funding; Grant; Human; Hypothalamic structure; Individual Differences; Information Services; Journals; Lesion; Library Services; Maps; Medial; Mediating; National Center for Research Resources; Neurosciences; Pathology; Physiologic pulse; Physiological; Pituitary Gland; Prefrontal Cortex; Primates; Principal Investigator; Process; Psychopathology; Research; Research Infrastructure; Resources; Role; Services; Source; Structure of terminal stria nuclei of preoptic region; System; United States National Institutes of Health; Wisconsin; Work; cost; relating to nervous system; showing emotion

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Objective: To understand the neural system underlying the expression of emotion in primates. Using EPI pulse sequence mapping of functional brain connectivity and accounting for physiological fluctuations, we have found a significant connectivity between the mid- posterior cingulated region and the medial PFC. In addition, we have found indications of connectivity in the "default network," thought to be associated with integrating cognitive and emotional processes, that included regions of the medial PFC and the insular. The findings from these studies will be highly relevant to humans, addressing the role of amygdala-orbitofrontal interactions in mediating normal emotion and psychopathology. This work used WNPRC Animal Services, Pathology, Operational Services, and Library & Information Services. PUBLICATIONS: Jahn AL, Fox AS, Abercrombie HC, Shelton SE, Oakes TR, Davidson RJ, Kalin NH. (2010) Subgenual prefrontal cortex activity predicts individual differences in hypothalamic-pituitary-adrenal activity across different contexts. Biological Psychiatry 67(2), 175-81. PMID: 19846063, PMCID: PMC2804442. Fox AS, Shelton SE, Oakes TR, Converse AK, Davidson RJ, Kalin NH. (2010) Orbitofrontal Cortex Lesions Alter Anxiety-Related Activity in the Primate Bed Nucleus of Stria Terminalis. Journal of Neuroscience, 30 (20), 7023-7027. PMID: 20484644, PMCID: PMC2915894.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 目的：了解情绪表达背后的神经系统 灵长类动物。 使用 EPI 脉冲序列绘制功能性大脑连接并解释 生理波动，我们发现中层之间存在显着的连通性 后扣带区和内侧 PFC。此外，我们还发现 “默认网络”中的连接指示，被认为与 整合认知和情感过程，包括内侧区域 PFC 和岛叶。这些研究的结果将高度相关 人类，探讨杏仁核-眶额相互作用在调解中的作用 正常情绪和精神病理学。 这项工作使用了 WNPRC 动物服务、病理学、运营服务和图书馆 及信息服务。 出版物： 扬 AL、福克斯 AS、阿伯克龙比 HC、谢尔顿 SE、奥克斯 TR、戴维森 RJ、卡林 NH。 (2010)膝下前额叶皮层活动预测个体差异 不同背景下的下丘脑-垂体-肾上腺活动。 生物精神病学 67(2)、175-81。 PMID：19846063，PMCID：PMC2804442。 福克斯 AS、谢尔顿 SE、奥克斯 TR、匡威 AK、戴维森 RJ、卡林 NH。 (2010) 眶额皮层损伤改变灵长类动物床核的焦虑相关活动 终纹。神经科学杂志，30 (20), 7023-7027。 PMID：20484644， PMCID：PMC2915894。