TMS FOR PAIN IN CHRONIC PANCREATITIS

TMS 治疗慢性胰腺炎疼痛

• 批准号: 7606943
• 负责人: Steven David Freedman
• 金额: $ 5.99万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606943
• 关键词: Adverse effects; Analgesics; Computer Retrieval of Information on Scientific Projects Database; Equilibrium; Functional disorder; Funding; Glutamates; Grant; Institution; Intake; Magnetic Resonance Imaging; Measures; Pain; Patients; Physiological; Pilot Projects; Population; Protocols documentation; Purpose; Quality of life; Relative (related person); Research; Research Personnel; Resources; Safety; Source; United States National Institutes of Health; Visceral pain; Visual Analogue Pain Scale; chronic pancreatitis; experience; gamma-Aminobutyric Acid; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this protocol is to investigate a possible novel treatment for intractable visceral pain in patients with chronic pancreatitis. The first aim of this study is to examine whether slow repetitive TMS (rTMS) applied to SII in patients with pain and chronic pancreatitis has an analgesic effect as measured by changes in the Visual Analogue Scale (VAS) for pain and a decrease in analgesic intake, as well as an overall improvement in quality of life. The second aim of the study is to assess the safety of rTMS in this patient population. In the pilot study done previously none of the patients experienced any adverse effects of a single session of rTMS. The hypothesis of this aim is that the proposed rTMS protocol will be safe for this patient population. The third aim of the study is to study the physiologic mechanism of action of rTMS in these patients using magnetic resonance imaging (MRI). They hypothesize that the balance of GABA and glutamate will be abnormal in SII in patients with pain from chronic pancreatitis, with a relative decrease in GABA and increase in glutamate indication an abnormal, hyperexcitabile dysfunction. This abnormality will be normalized by rTMS in correlation with its analgesic effect.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该方案的目的是研究一种可能针对慢性胰腺炎患者顽固性内脏疼痛的新型治疗方法。这项研究的第一个目的是检查疼痛和慢性胰腺炎患者中应用于SII的缓慢重复TMS（RTM）是否具有镇痛作用，这是通过视觉模拟量表（VAS）的变化来衡量疼痛和止痛摄入量的减少，以及生活质量的总体改善。 该研究的第二个目的是评估RTM在该患者人群中的安全性。在先前进行的试点研究中，任何患者都没有发生任何一次RTMS的不利影响。该目标的假设是建议的RTMS方案对该患者人群是安全的。该研究的第三个目的是使用磁共振成像（MRI）研究这些患者RTMS的生理作用机理。他们假设在慢性胰腺炎疼痛患者的SII中，GABA和谷氨酸的平衡将异常，GABA的相对降低和谷氨酸症状的增加表明异常，过度刺激性的功能障碍。这种异常将通过RTM与其镇痛作用相关。