CYSTIC FIBROSIS GENE DEFECTS DATA SHARING PROJECT

囊性纤维化基因缺陷数据共享项目

• 批准号: 7366537
• 负责人: Steven David Freedman
• 金额: $ 0.81万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7366537
• 关键词: CYSTIC; FIBROSIS; GENE; DEFECTS; DATA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A secure web-based data archiving and analysis program is being developed to facilitate multi-center research in the physiologic expression of cystic fibrosis gene defects. To investigate respiratory epithelial function in cystic fibrosis, the transepithelial electric potential difference across upper and lower respiratory mucosal cells is being measured in patients with cystic fibrosis, recurrent acute pancreatitis and healthy controls in response to the administration of amiloride (an inhibitor of sodium absorption). An intermediate response between the healthy controls and the cystic fibrosis response has been noted in some patients with recurrent acute pancreatitis. To facilitate data sharing across geographically remote sites and to create an easy to use interface for data entry and data submission, a form-based web application has been developed and is ready to be deployed on a secure server with an encrypted system. This application allows visualization of both electronic and scanned paper records and stores analysis results and subject information in a relational database back-end.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。正在开发一个安全的基于Web的数据归档和分析程序，以促进囊性纤维化基因缺陷的生理表达中的多中心研究。为了研究囊性纤维化中的呼吸性上皮功能，在囊性纤维化，复发性急性胰腺炎和健康对照的患者中，正在测量上和下呼吸道粘膜细胞之间的跨呼吸电位差异，以响应艾米洛雷德的给药（一种吸收钠的抑制剂）。一些复发性急性胰腺炎患者已经注意到，健康对照与囊性纤维化反应之间的中间反应。为了促进跨地理上远程站点的数据共享，并创建易于使用的数据输入和数据提交的接口，已经开发了基于表单的Web应用程序，并准备在使用加密系统的安全服务器上部署。该应用程序允许可视化电子和扫描的纸质记录，并在关系数据库后端存储分析结果和主题信息。