ETHNIC DIFFERENCES IN ACUTE PAIN AND ANALGESIC RESPONSE

急性疼痛和镇痛反应的种族差异

基本信息

批准号：
7950742
负责人：
BARBARA A HASTIE
金额：
$ 0.18万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-12-01 至 2009-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7950742
关键词：
Absence of pain sensation Acute Acute Pain Adverse effects Age Analgesics Clinical Clinical Research Computer Retrieval of Information on Scientific Projects Database Development Drug Kinetics Ethnic group Fentanyl Funding Genetic Goals Grant Hour Individual Institution Measures Minority Modeling Monitor Opioid Pain Patients Perception Pharmacodynamics Physiological Postoperative Pain Procedures Psychophysiology Psychosocial Factor Quality of life Research Research Design Research Personnel Resources Source Translational Research United States National Institutes of Health biopsychosocial ethnic difference health disparity psychosocial response therapy design third molar extraction

Absence of pain sensation Acute Acute Pain Adverse effects Age Analgesics Clinical Clinical Research Computer Retrieval of Information on Scientific Projects Database Development Drug Kinetics Ethnic group Fentanyl Funding Genetic Goals Grant Hour Individual Institution Measures Minority Modeling Monitor Opioid Pain Patients Perception Pharmacodynamics Physiological Postoperative Pain Procedures Psychophysiology Psychosocial Factor Quality of life Research Research Design Research Personnel Resources Source Translational Research United States National Institutes of Health biopsychosocial ethnic difference health disparity psychosocial response therapy design third molar extraction

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项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will use a common acute clinical pain model to identify and characterize psychosocial, physiological and genetic factors that contribute to ethnic group differences in pain perception and analgesia. Aim 1 will determine ethnic group differences in perceptual and physiological responses to acute post-operative pain and to examine how those are related to genetic, pre-operative psychophysical and psychosocial factors. Aim 2 will determine ethnic differences in opioid analgesia and side effects and will examine genetic, pharmacokinetic, pharmacodynamic, and psychosocial factors that explain group differences in analgesic responses. 300 minority and white patients age range 18-who undergo third molar extraction will be included in this study. Preoperative experimental pain responses and psychosocial measures will be assessed and postoperative pain levels along with pharmacokinetic; and pharmacodynamic responses to the opioid fentanyl will be monitored. Group differences in post-operative pain as well as analgesic responses immediately and for several hours post-operatively and up to 3 days post-procedure will also be assessed. The long-term goal of this study is to develop a programmatic line of research designed to elucidate biopsychosocial contributions to ethnic differences in pain and to eventually engage in translational research to reduce health disparities in clinical pain through the development of interventions designed to enhance the quality of life of individuals with pain.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。这项研究将使用常见的急性临床疼痛模型来识别和表征会导致疼痛感知和镇痛的族裔群体差异的社会心理，生理和遗传因素。 AIM 1将确定种族群体对急性术后疼痛的感知和生理反应的差异，并研究这些族裔与遗传，术前心理物理和心理社会因素的关系。 AIM 2将确定阿片类镇痛和副作用的种族差异，并将检查遗传，药代动力学，药物动力学和心理社会因素，这些因素解释了镇痛反应中群体差异。本研究将包括300名少数族裔和白人患者年龄18岁的年龄范围18岁。术前实验性疼痛反应和社会心理措施将进行评估，并在术后疼痛水平以及药代动力学；将监测对阿片类芬太尼的药效动力反应。术后疼痛以及镇痛反应的群体差异也会立即在术后和最多3天后进行几个小时。这项研究的长期目标是开发一项计划研究线，旨在阐明对疼痛的种族差异的生物心理社会贡献，并最终从事转化研究，以通过旨在提高疼痛患者生活质量的干预措施来减少临床疼痛的健康差异。