AFRICAN AMERICANS WITH RA (CLEAR) REGISTRY

有 RA（明确）登记的非裔美国人

• 批准号: 7607136
• 负责人: Edwin Allan Smith
• 金额: $ 0.76万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607136
• 关键词: Affect; African; African American; Alabama; Computer Retrieval of Information on Scientific Projects Database; Count; DEXA; Environmental Risk Factor; Fatigue; Fever; Funding; Genetic; Grant; Hand; Health; Inflammation; Institution; Joints; Lead; Medical; Monitor; North Carolina; Observational Study; Office Visits; Other Genetics; Participant; Quality of life; Questionnaires; Registries; Research; Research Personnel; Resources; Rheumatoid Arthritis; Scanning; Serum; Severities; Sleep; Source; South Carolina; Symptoms; Tennessee; United States National Institutes of Health; Universities; Visit; Washington; bone; chronic autoimmune disease; foot; illness length; loss of function; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is an observational study that will monitor the progression of Rheumatoid Arthritis (RA) in approximately 400 RA participants. Rheumatoid arthritis is a chronic autoimmune disease that is characterized by inflammation of the joints. If inflammation persists, it can lead to bone and joint damage and loss of function. Symptoms of new onset RA may also include tender joints, fatigue, fever, and difficulty sleeping. RA may affect the ability to function, decrease physical health, and reduce the overall quality of life. The cause of RA is not known, but research has indicated it is likely a combination of genetic and environmental factors. Researchers at the Medical University of South Carolina, University of Alabama at Birmingham, Emory University, Washington University, University of Tennessee at Memphis, Vanderbilt University, and University of North Carolina are engaged in the study of genetic and other factors that determine severity of rheumatoid arthritis in African-Americans and response to treatment. Participants in the study will be asked to complete three (3) office visits. A baseline visit, a visit at 36 months disease duration and a visit at 60 month's duration. DNA/Serum, x-rays of hands and feet, physical exam, joint counts, and participant questionnaires are filled out at every visit. A DEXA scan occurs at the baseline and 60 month visit.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究是一项观察性研究，该研究将监测大约400名RA参与者中类风湿关节炎（RA）的进展。 类风湿关节炎是一种慢性自身免疫性疾病，其特征是关节发炎。 如果炎症持续存在，它可能会导致骨骼和关节损伤和功能丧失。 新发作的症状也可能包括嫩关节，疲劳，发烧和睡眠困难。 RA可能会影响功能，降低身体健康并降低整体生活质量的能力。 RA的原因尚不清楚，但研究表明，它可能是遗传因素和环境因素的组合。 南卡罗来纳州医科大学，阿拉巴马大学伯明翰大学，埃默里大学，华盛顿大学，田纳西大学，孟菲斯大学，范德比尔特大学和北卡罗来纳大学研究了确定非裔美国人类风湿关节炎的严重程度的遗传和其他因素。 该研究的参与者将被要求完成三（3）次办公室访问。基线访问，疾病持续36个月的访问以及60个月的访问。 每次访问都会填写DNA/血清，手脚X射线，身体检查，联合计数和参与者问卷。 在基线和60个月访问时进行DEXA扫描。