ABCON

艾布康

• 批准号: 7607151
• 负责人: Edwin Allan Smith
• 金额: $ 0.25万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607151
• 关键词: African American; Alabama; Autoimmune Process; Biological Markers; Blood; Blood Cells; Blood specimen; California; Cell surface; Collaborations; Computer Retrieval of Information on Scientific Projects Database; DNA; Disease Marker; Disease Progression; Funding; Gene Expression; Genes; Genetic; Genetic Materials; Grant; Inherited; Institution; Medical; Minnesota; New York; North Carolina; Participant; Pattern; Persons; Pharmaceutical Preparations; Proteins; Purpose; Quality of life; RNA; Research; Research Institute; Research Personnel; Resources; Rheumatoid Arthritis; Role; Serum; Severities; Source; South Carolina; Test Result; Testing; United States National Institutes of Health; Universities; research study; African American; Alabama; Autoimmune Process; Biological Markers; Blood; Blood Cells; Blood specimen; California; Cell surface; Collaborations; Computer Retrieval of Information on Scientific Projects Database; DNA; Disease Marker; Disease Progression; Funding; Gene Expression; Genes; Genetic; Genetic Materials; Grant; Inherited; Institution; Medical; Minnesota; New York; North Carolina; Participant; Pattern; Persons; Pharmaceutical Preparations; Proteins; Purpose; Quality of life; RNA; Research; Research Institute; Research Personnel; Resources; Rheumatoid Arthritis; Role; Serum; Severities; Source; South Carolina; Test Result; Testing; United States National Institutes of Health; Universities; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research study is being performed in collaboration with other researchers who have formed a group called the Autoimmune Biomarkers Collaborative Network (ABCoN). These researchers are at the University of Minnesota, The University of Alabama at Birmingham and Alabama Rheumatologists, the University of North Carolina, Emory University, The Medical University of South Carolina, SurroMed Inc., in California and North Shore LIJ Research Institute in New York. The purpose of the ABCoN research study is to look for patterns of "gene expression" in participants with Rheumatoid Arthritis (RA). This study may help determine whether gene expression patterns in peripheral blood cells differ in RA participants who respond to treatments versus participants who do not respond as well. Blood samples will also be used to search for proteins that may be useful markers of severity of rheumatoid arthritis in African Americans. There will be 400 subjects participating in this study and participation will last for 3 to 5 years. As part of the study, blood will be drawn to obtain genetic material (mainly DNA) circulating blood cells, and serum. This genetic material will be used to try to identify the "genetic factors" or genes that a person inherits that make him or her more likely to develop RA. In addition, RNA will be obtained from blood cells to look for patterns of "gene expression". These blood samples will also be used to search for proteins in blood or on the surface of cells that may be useful markers of disease or drug responsiveness. Over the course of the study, a specific gene or genes that cause rheumatoid arthritis may be identified. DNA and RNA may be tested for those genes to further explore their role in the cause of Rheumatoid Arthritis. Testing results will be shared with participants and participants will be followed to observe if there are changes in certain findings such as disease progression and quality of life.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究正在与其他研究人员合作进行，这些研究人员组建了一个名为“自动免疫标志物协作网络”（ABCON）的小组。 这些研究人员位于明尼苏达大学，阿拉巴马大学伯明翰大学和阿拉巴马州风湿病学家，北卡罗来纳大学埃默里大学，南卡罗来纳州医科大学，加利福尼亚州和纽约北岸Lij Research Institute。 ABCON研究研究的目的是寻找类风湿关节炎参与者（RA）的“基因表达”模式。 这项研究可能有助于确定对治疗反应与不反应的参与者的RA参与者的外周血细胞中基因表达模式是否有所不同。 血样还将用于寻找可能是非裔美国人类风湿关节炎严重性标志的蛋白质。 将有400名参与这项研究的受试者，参与将持续3至5年。 作为研究的一部分，将吸收血液以获得遗传物质（主要是DNA）循环血细胞和血清。 这种遗传物质将用于识别一个人继承的“遗传因素”或使他或她更可能发展RA的基因。 另外，将从血细胞中获得RNA，以寻找“基因表达”的模式。 这些血液样本还将用于搜索血液中的蛋白质或细胞表面上可能是有用的疾病或药物反应性标记的。 在研究过程中，可以鉴定出引起类风湿关节炎的特定基因或基因。 可以测试这些基因的DNA和RNA，以进一步探索其在类风湿关节炎原因中的作用。 测试结果将与参与者分享，并将遵循参与者观察某些发现的变化，例如疾病进展和生活质量。