CHARLESTON METRO STUDY

查尔斯顿地铁研究

• 批准号: 7607155
• 负责人: Jimmy D. Alele
• 金额: $ 0.35万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607155
• 关键词: Address; Adult; Affect; African American; Age; Ankle; Area; Biology; Blood Pressure; C-reactive protein; Cardiovascular Diseases; Caucasians; Caucasoid Race; Cell physiology; Chronic Disease; Clinic; Computer Retrieval of Information on Scientific Projects Database; Creatinine; Cross-Sectional Studies; Disease Outcome; Elderly; Frequencies; Funding; Grant; Health; Hyperglycemia; Hypertrophy; Institution; Insulin; Insulin Resistance; Left Ventricular Mass; Lipoprotein (a); Lipoprotein (a-); Lipoproteins; Measures; Microalbuminuria; Outcome; Participant; Persons; Phase; Population; Potassium; Race; Rate; Recruitment Activity; Renal function; Research; Research Personnel; Resources; Risk; Risk Factors; Sampling; Socioeconomic Status; Sodium; Source; South Carolina; Structure of beta Cell of islet; Testing; United States National Institutes of Health; Woman; cohort; follow-up; glycemic control; indexing; men; metropolitan; middle age; post gamma-globulins; prospective; sex; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to recruit, examine, and follow a new population sample to address important issues for middle-aged and older adults in the Charleston, South Carolina metropolitan area, considering chronic disease outcomes (cardiovascular disease [CVD], hyperglycemia, and impaired kidney function) that occur in the region at rates much higher than national averages and show a predilection to affect African-Americans (AA). The study will include a total of 1000 middle-aged men and women with known CVD who have been frequency matched according to sex, age, race, and clinic to another 1000 persons without CVD. Cross-sectional analyses will compare levels of CVD risk factors, glycemia, and kidney function for Caucasian (Cau) and AA participants, and the corresponding prospective phase will include a follow up examination 3 years after the initial examination to identify factors that increase the risk of CVD outcomes, change in glycemic function and change in kidney function. The unifying hypotheses to test are how CVD risk factors and outcomes vary between Caucasian and AA residents of metropolitan Charleston according to differences in biology, socio-economic status, and health access. Specifically, this biracial study of adults with and without CVD will (1) identify, recruit, examine and track a biracial cohort to be examined for CVD, glycemia and kidney function with a cross-sectional and prospective analytic components (2) test cross-sectionally for the effects of race on CVD risk factors, glycemic control according to pancreatic beta cell function, insulin resistance measures, and kidney function in adults, (3) test for effects of specific risk factors (lipoprotein subparticles, lipoprotein(a), left ventricular mass and hypertrophy, ankle-brachial blood pressure index, C-reactive protein, insulin, postprandial glycemia, creatinine, cystatin-C, microalbuminuria, and urinary sodium and potassium) on chronic disease outcomes, initially using cross-sectional and later prospective analyses.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们建议招募、检查和追踪一个新的人口样本，以解决南卡罗来纳州查尔斯顿大都市区中老年人的重要问题，同时考虑慢性疾病的结果（心血管疾病 [CVD]、高血糖和肾功能受损） ），该地区的发生率远高于全国平均水平，并且优先影响非裔美国人 (AA)。该研究将总共包括 1000 名患有 CVD 的中年男性和女性，他们根据性别、年龄、种族和临床情况与另外 1000 名没有 CVD 的人进行频率匹配。 横断面分析将比较白种人 (Cau) 和 AA 参与者的 CVD 危险因素、血糖和肾功能水平，相应的前瞻性阶段将包括初次检查后 3 年的随访检查，以确定增加风险的因素CVD 结果、血糖功能变化和肾功能变化。 需要测试的统一假设是查尔斯顿大都市的白人和 AA 居民之间的 CVD 危险因素和结果如何根据生物学、社会经济地位和健康状况的差异而变化。具体来说，这项针对患有和不患有 CVD 的成年人的混血研究将 (1) 识别、招募、检查和跟踪混血队列，以通过横断面和前瞻性分析成分检查 CVD、血糖和肾功能 (2) 测试交叉部分研究种族对 CVD 危险因素、根据胰腺 β 细胞功能的血糖控制、胰岛素抵抗措施和成人肾功能的影响，(3) 测试特定危险因素（脂蛋白亚颗粒、脂蛋白 (a)、左心室质量和肥厚、踝臂血压指数、C反应蛋白、胰岛素、餐后血糖、肌酐、半胱氨酸蛋白酶抑制剂-C、微量白蛋白尿以及尿钠和尿钾）对慢性病结果的影响，最初使用横断面数据，后来使用前瞻性数据分析。