METABOLIC BONE DISEASE AND ARTERIAL CALCIFICATION IN CHARLESTON ADULT MEN WITH

查尔斯顿成年男性的代谢性骨病和动脉钙化

• 批准号: 7719581
• 负责人: Jimmy D. Alele
• 金额: $ 0.97万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719581
• 关键词: Accounting; Adult; African American; Age; Bone Density; C-reactive protein; Cardiovascular Diseases; Caucasians; Caucasoid Race; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Institution; Lipids; Metabolic Bone Diseases; Metabolic syndrome; Participant; Race; Research; Research Personnel; Resources; Score; Smoking History; Source; Testing; United States National Institutes of Health; bone loss; bone turnover; calcification; caucasian American; coronary artery calcification; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The metabolic syndrome is a common problem, which is associated with cardiovascular disease. This proposal tests the null hypothesis that the degree of arterial calcification in adults with the metabolic syndrome is not related to race or to bone mineral density (BMD). Specific Aim 1. To determine if the metabolic syndrome is associated with coronary artery calcification, we will examine the relations between coronary artery calcification score and the presence or absence of the metabolic syndrome. We will also look for the effects of association between the metabolic syndrome and race, age, lipids, history of smoking as well as levels of C-reactive protein and arterial calcification. Specific Aim 2. To determine if coronary artery calcification is associated with lower bone mineral density (BMD) in African American (AA) and Caucasian (Cau) participants, we will examine the relationship between arterial calcification and bone mineral density in AA and Cau subjects. Taking into account the possibility of subclinical bone loss, we will also examine the relationship between markers of bone turnover and arterial calcification in the two groups.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 代谢综合征是一个常见问题，与心血管疾病有关。该提案检验了零假设，即患有代谢综合征的成年人的动脉钙化程度与种族或骨矿物质密度 (BMD) 无关。 具体目标 1. 为了确定代谢综合征是否与冠状动脉钙化相关，我们将检查冠状动脉钙化评分与是否存在代谢综合征之间的关系。我们还将寻找代谢综合征与种族、年龄、血脂、吸烟史以及 C 反应蛋白水平和动脉钙化之间关联的影响。 具体目标 2. 为了确定非裔美国人 (AA) 和白种人 (Cau) 参与者的冠状动脉钙化是否与较低的骨矿物质密度 (BMD) 相关，我们将检查 AA 和 Cau 受试者的动脉钙化与骨矿物质密度之间的关系。考虑到亚临床骨丢失的可能性，我们还将检查两组骨转换标志物与动脉钙化之间的关系。