2020 Oxygen Radicals Gordon Research Conference (GRC) and Gordon Research Seminar (GRS)

2020年氧自由基戈登研究会议（GRC）和戈登研究研讨会（GRS）

• 批准号: 9912443
• 负责人: Yvonne M. W. Janssen-Heininger
• 金额: $ 2.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-22 至 2021-01-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9912443
• 关键词: Academia; Address; Age; Aging; Applications Grants; Applied Research; Area; Atmosphere; Award; Basic Science; Biology; California; Cell physiology; Cessation of life; Chemicals; Chemistry; Collaborations; Communication; Country; Diagnostic; Disease; Elevator; Endoplasmic Reticulum; Ensure; Environment; Ethnic Origin; Event; FDA approved; Failure; Fertilization; Fostering; Free Radicals; Functional disorder; Funding; Future; Gender; Goals; Government; Health; Homeostasis; Hour; Illinois; Incentives; Industry; Iron; Knowledge; Link; Lipids; Location; Medicine; Metabolic; Metabolism; Methodology; Mitochondria; Nationalities; Oral; Organelles; Oxidants; Oxidation-Reduction; Participant; Pharmaceutical Preparations; Play; Policies; Post-Translational Protein Processing; Postdoctoral Fellow; Published Comment; Reactive Oxygen Species; Regulation; Research; Research Personnel; Research Project Grants; Rhea; Role; Running; Scientist; Senior Scientist; Social Planning; Students; Therapeutic; Translations; Travel; Twitter; Underrepresented Minority; United States; United States National Institutes of Health; Universities; Vermont; Woman; base; career; career development; clinical development; cost; drug development; educational atmosphere; experience; graduate student; healthspan; innovation; inquiry-based learning; lectures; meetings; novel; peer; posters; programs; proteostasis; response; senescence; sensor; social; stem cells; symposium; therapeutic development; tool; tumor metabolism

Project Summary This conference grant proposal seeks funds for a Gordon Research Conference (GRC) on Oxygen Radicals: Chemical Reactivity, Metabolism, and Opportunities for Therapeutic Development to be held in Ventura CA February 2-7, 2020, in conjunction with a Gordon Research Seminar (GRS) for trainees, organized by two trainees (Cheryl van de Wetering, and Rhea Bovee), to be held immediate prior to the GRC, February 1-2, 2020 at the same location. We present an exciting program that brings together diverse fields of oxidant research, integrating recent discoveries of new oxidant species, with methodological advances, studies of biology, organelle dysfunction and metabolism, and aging, and plenary and round table discussions focusing on redox- based drugs in clinical development. The program includes senior scientists (giving the keynote lectures), as was as junior and mid-career scientists, and we have 10 slots for invited talks from submitted abstracts. Speakers are from academia, industry and the NIH, represent 19 countries and will be sharing their latest discoveries in nine sessions: Keynote session I: Oxygen Radicals: connecting chemistry with biology and medicine; Mitochondria from energy power houses to metabolite regulators; Oxygen radicals in stem cell function, senescence and aging; Redox in translation: Hurdles and ways forward toward therapeutics; Endoplasmic reticulum-redox control of proteostasis and dysregulation in disease; Reactive lipids in death, homeostasis and as therapeutics: Ferroptosis, and beyond; Advances in redox sensors, probes, and diagnostics; Oxygen radicals in metabolism; Keynote session II: Technical advances in the study of oxygen radicals; opportunities and challenges. Other conference highlights are the power hour and representation by women with a twitter feed #REDOXWOMEN and assurance that at least 40% of all presenters or discussion leaders are women. We will have elevator pitch sessions to highlight posters, and a policy of first questions by trainees. We will have welcome tables and social events to be inclusive of new attendees and continue the tradition of the Iron Bolt Award for the most notable comment. Collectively, this program will ensure a vibrant and collegial atmosphere to share the top discoveries in research on oxygen radicals, their involvement in disease and aging and potential avenues for therapeutic development.

项目概要 本会议拨款提案为戈登氧自由基研究会议 (GRC) 寻求资金： 化学反应、代谢和治疗开发机会将在加利福尼亚州文图拉举行 2020 年 2 月 2 日至 7 日，与受训人员一起举办的戈登研究研讨会 (GRS)，由两位 实习生（Cheryl van de Wetering 和 Rhea Bovee），将于 2020 年 2 月 1 日至 2 日 GRC 之前举行 在同一位置。我们提出了一个令人兴奋的计划，汇集了氧化剂研究的不同领域， 将新氧化剂种类的最新发现与方法学进展、生物学研究相结合， 细胞器功能障碍和新陈代谢、衰老，以及重点关注氧化还原的全体会议和圆桌讨论 临床开发中的基础药物。该计划包括资深科学家（作主题演讲），如 作为初级和中期科学家，我们有 10 个位置用于根据提交的摘要进行邀请演讲。扬声器 来自学术界、工业界和 NIH，代表 19 个国家，将分享他们在 九场会议：主题演讲一：氧自由基：化学与生物学和医学的联系； 线粒体从能源发电厂到代谢调节器；氧自由基在干细胞功能中的作用， 衰老和老化；翻译中的氧化还原：治疗学的障碍和前进的道路；内质 疾病中蛋白质稳态和失调的网状氧化还原控制；死亡、体内平衡和反应中的反应性脂质 作为治疗方法：铁死亡等；氧化还原传感器、探针和诊断技术的进步；氧自由基 在新陈代谢中；主题演讲二：氧自由基研究的技术进展；机会和 挑战。会议的其他亮点包括权力时间和女性代表在推特上的发言 #REDOXWOMEN 并保证所有演讲者或讨论领导者中至少 40% 是女性。我们将 举办电梯推介会以突出海报，并制定学员提出第一个问题的政策。我们将热情欢迎 桌子和社交活动包括新的参与者，并延续铁螺栓奖的传统 最值得注意的评论。总的来说，该计划将确保充满活力和学院氛围来分享 氧自由基研究的顶级发现、氧自由基与疾病和衰老的关系以及潜在的途径 治疗的发展。