Stromal Cells in Immunity and Disease

基质细胞在免疫和疾病中的作用

• 批准号: 9910333
• 负责人: Thale Cross Jarvis
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-03 至 2021-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9910333
• 关键词: Antigen-Presenting Cells; Area; Autoimmune Diseases; B-Lymphocytes; Biology; British Columbia; Canada; Cancer Patient; Cell Communication; Cell Separation; Cells; Cellular biology; Chronic; Clinical; Collaborations; Consensus; Development; Disease; Education; Educational workshop; Fibrosis; Future; Goals; HIV Infections; Health; Human; Immune System Diseases; Immune response; Immune system; Immunity; Immunologics; Immunology; Infection; Inflammation; Inflammatory; Joints; Knowledge; Leukocytes; Location; Lymphocyte; Malignant Neoplasms; Mechanics; Methodology; Modeling; Natural Immunity; Nomenclature; Occupations; Outcome; Phenotype; Play; Population; Process; Research; Research Personnel; Role; Scientist; Speed; Stromal Cells; Supporting Cell; T-Lymphocyte; Technology; Therapeutic; Tissues; Translational Research; Work; adaptive immunity; cancer vaccination; chronic infection; clinical practice; clinically relevant; defense response; improved; innovation; interest; lymphoid organ; meetings; migration; next generation; posters; symposium; tissue repair; tool

ABSTRACT Support is requested for a Keystone Symposia conference entitled Stromal Cells in Immunity and Disease, organized by Drs. Scott N. Mueller, Jason G. Cyster, Reina E. Mebius and Theresa Lu. The conference will be held in Victoria, British Columbia Canada from February 19-23, 2020. Non-hematopoietic stromal cells play important roles in many tissues, constructing tissue microenvironments, contributing to tissue repair, defense and immune responses. Within lymphoid organs, stromal cells organize and interact with leukocytes in an immunologically important manner. In addition to organizing T and B cell segregation and expressing lymphocyte survival factors, stromal cells support the migration and interactions between antigen presenting cells and naïve T and B cells during the initiation of immune responses and influence the outcome between tolerance and immunity. Stromal cells also play instrumental roles in coordinating immune responses in non-lymphoid tissues and in inflammatory and autoimmune diseases, and in chronic infection. For instance, stromal cells have been shown to be dysregulated during HIV infection and also in cancer patients. Furthermore, stromal cells are being harnessed for therapeutic applications in several diseases, an area that holds great promise for improving human health. Our understanding of stromal cell populations and their contributions to innate and adaptive immunity as well as immunological diseases, cancer and vaccination has grown exponentially over the past few years. This emerging field has gained enormous momentum due to increasingly sophisticated tools to dissect the fundamental biology and clinical importance of this cellular compartment. This conference is being held jointly with Fibrosis and Tissue Repair: From Molecules and Mechanics to Therapeutic Approaches. This joint pairing will bring together basic and clinical scientists with interdisciplinary interests in stromal cell biology and disease treatment to discuss critical fundamental and translational advances. The goals of this conference are to showcase cutting-edge results and new directions in the field, stimulate interactions and provide a forum for trainees and new investigators to present their work and interact with leaders in the field.

抽象的 请求支持题为“免疫和疾病中的基质细胞”的 Keystone 研讨会， 由 Scott N. Mueller 博士、Jason G. Cyster、Reina E. Mobius 和 Theresa Lu 组织。 2020年2月19日至23日在加拿大不列颠哥伦比亚省维多利亚举行。 非造血基质细胞在许多组织中发挥重要作用，构建组织微环境， 在淋巴器官内，基质细胞有助于组织修复、防御和免疫反应。 除了组织 T 细胞和 B 细胞外，还以免疫学上重要的方式与白细胞相互作用。 分离和表达淋巴细胞生存因子，基质细胞支持迁移和相互作用 在免疫反应启动期间，抗原呈递细胞与初始 T 细胞和 B 细胞之间 影响耐受性和免疫之间的结果。 协调非淋巴组织以及炎症和自身免疫性疾病的免疫反应，以及 例如，在慢性感染中，基质细胞已被证明在艾滋病毒感染期间失调。 此外，基质细胞也被用于一些癌症患者的治疗应用。 疾病，这是一个对改善人类健康具有巨大前景的领域。 人群及其对先天性和适应性免疫以及免疫疾病、癌症的贡献 疫苗接种在过去几年中呈指数级增长，这一新兴领域获得了巨大的发展。 由于剖析基础生物学和临床重要性的工具日益复杂，势头强劲 本次会议与纤维化和组织修复：来自 这种联合配对将把基础和临床结合起来。 对基质细胞生物学和疾病治疗具有跨学科兴趣的科学家讨论关键问题 本次会议的目标是展示前沿成果。 和该领域的新方向，激发互动，并为学员和新研究人员提供一个论坛 展示他们的工作并与该领域的领导者互动。