Bioenergetics in Health and Diseases

健康与疾病中的生物能量学

基本信息

批准号：
10609120
负责人：
Thale Cross Jarvis
金额：
$ 1.74万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-01-01 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10609120
关键词：
Acceleration Adipose tissue Aging Area Bioenergetics Biology Clinical Collaborations Colorado Defect Development Disease Drug Targeting Educational workshop Elements Energy Metabolism Exercise Exercise Physiology Fatty acid glycerol esters Fibrosis Futile Cycling Future Health Heart Homeostasis Immunology Industry Knowledge Life Malignant Neoplasms Metabolic Metabolic Diseases Metabolism Methodology Mitochondria Molecular Neurodegenerative Disorders Outcome Pathology Process Proteomics Reporting Research Research Personnel Resolution Role Science Scientist Technology Underrepresented Populations Work age related career clinical practice design expectation human disease improved insight interdisciplinary collaboration lipidomics metabolomics mitochondrial metabolism multidisciplinary new technology next generation novel novel strategies posters programs symposium synergism tumor metabolism

项目摘要

ABSTRACT Support is requested for a Keystone Symposia conference entitled Bioenergetics in Health and Diseases, organized by Drs. Shingo Kajimura, Anna Krook and Jared Rutter. The conference will be held in Keystone, Colorado from January 15-19, 2023. Bioenergetic defects lie at the heart of metabolic disease, age-related disease, and cancer; however, what initiates the processes remain insufficiently understood. Over the last several years, the field has been transformed because of several breakthroughs and continues to expand. For instance, new mechanisms of futile cycling were identified. Novel regulators of mitochondrial metabolism and their roles in metabolic diseases and cancer have been reported. The sensitivity and resolution of metabolomics, lipidomics, and proteomics technologies are rapidly increasing. Thus, there is momentum to organize a conference that focuses on this exciting and emerging topic in the context of metabolic diseases, exercise, and cancer. The program includes a multi-disciplinary speaker lineup that will cover topics such as mitochondrial bioenergetics, cancer metabolism, exercise physiology, and metabolic diseases. Moreover, this conference will be held jointly with the Keystone Symposia conference, “Adipose Tissue: Energizing Good Fat.” This pairing will feature three shared sessions: Metabolic Flux in Health and Disease, Bioenergetics and Energy Homeostasis, and Adipose Tissue and Metabolic Diseases. It is anticipated that these topics will create numerous new collaborations and cross-disciplinary interactions. All in all, this conference was designed to discuss the emerging questions in the field of bioenergetics in the context of metabolic diseases at molecular and organismal levels, in addition to facilitating synergy between established and new investigators in the field of energy metabolism.

抽象的请求支持题为“健康与疾病中的生物能学”的 Keystone 研讨会，由 Shingo Kajimura、Anna Krook 和 Jared Rutter 博士组织会议将在 Keystone 举行。科罗拉多州，2023 年 1 月 15 日至 19 日。生物能量缺陷是代谢疾病、年龄相关疾病和癌症的核心；然而，什么是生物能量缺陷？在过去的几年中，该领域一直没有得到足够的了解。因多项突破而转型，并不断拓展，例如新的机制。确定了线粒体代谢的新调节因子及其在代谢中的作用。代谢组学、脂质组学和癌症的敏感性和分辨率已有报道。因此，蛋白质组学技术正在迅速发展，因此有动力组织一次会议。重点关注代谢疾病、运动和癌症背景下这一令人兴奋的新兴主题。计划包括多学科演讲者阵容，涵盖线粒体生物能量学、此外，本次会议还将举办癌症代谢、运动生理学和代谢疾病。与 Keystone Symposia 会议联合举办的“脂肪组织：为好脂肪提供能量”。包括三个共享会议：健康和疾病中的代谢通量、生物能量学和能量稳态、预计这些主题将创造许多新的主题。总而言之，这次会议的目的是讨论合作和跨学科互动。在分子和代谢疾病背景下生物能学领域新出现的问题生物水平，除了促进该领域现有研究人员和新研究人员之间的协同作用能量代谢。