DIABETES PREVENTION PROGRAM OUTCOMES STUDY (DPPOS)

糖尿病预防计划成果研究 (DPPOS)

• 批准号: 7606549
• 负责人: ELIZABETH L BARRETT-CONNOR
• 金额: $ 0.31万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606549
• 关键词: Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Disease Outcome; Funding; Grant; Health Status; Institution; Intervention; Long-Term Effects; Metformin; Outcome; Outcome Study; Placebos; Prevention; Rate; Research; Research Personnel; Resources; Source; Testing; Translating; United States National Institutes of Health; diabetes prevention program; follow-up; improved; lifestyle intervention

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of the DPPOS is to evaluate the long-term effects of active DPP interventions on the development of a ) diabetes during a further 5-10 years of follow-up and b) composite diabetes-related microangiopathic and cardiovascular disease outcomes. The hypotheses being tested are that both the continued lifestyle intervention and metformin will provide continued separation in the rates of diabetes development, compared with the former placebo group, and that the prevention or delay of diabetes during the DPP and DPPOS will translate into reduced rates of composite outcomes and improved health status.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 DPPO的主要目的是评估活性DPP干预措施对a）糖尿病发展的长期影响，在另外5 - 10年的随访中，b）复合糖尿病相关的微血管病和心血管疾病结果。与以前的安慰剂组相比，持续的生活方式干预和二甲双胍的假设是，持续的生活方式干预和二甲双胍都将持续分离糖尿病发育率，并且在DPP和DPPO期间的预防或糖尿病的预防或延迟将转化为复合材料癌症的降低率和改善的健康状况。