Outcomes of Sleep Disorders in Older Men

老年男性睡眠障碍的后果

• 批准号: 7066039
• 负责人: ELIZABETH L BARRETT-CONNOR
• 金额: $ 15.42万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7066039
• 关键词: accidental falls; actigraphy; bone density; bone fracture; cardiovascular disorder risk; clinical research; cognition; functional ability; geriatrics; human mortality; human old age (65+); human subject; longitudinal human study; neuropsychological tests; outcomes research; patient oriented research; polysomnography; questionnaires; sleep apnea; sleep disorders

DESCRIPTION (provided by applicant): It is estimated that over 50% of adults aged 65 and older report some sleep disruption, while about 20% suffer from chronic insomnia. Obstructive sleep apnea, a major cause of daytime drowsiness, occurs in an estimated 20-60% of older people, depending on the definition used and the specific population being studied. Despite the high prevalence of sleep disorders in the elderly, there have been relatively few studies focused on the consequences. Most studies have been limited by cross-sectional design, small sample size, or lack of comprehensive and objective assessment of sleep. The proposed study, Outcomes of Sleep Disorders in Older Men, will take advantage of the established cohort that has been recruited for the Osteoporotic Fractures in Men (MrOS) study (5U01AR045647-Dr. Eric Orwoll, PI). MrOS, a 7-year study that began in July 1999, is a multi-center prospective study of approximately 6000 men aged 65 and older. During the MrOS baseline visit, a broad variety of measurements were collected, including body composition and body fat distribution (by DEXA and quantitative computed tomography), bone density, anthropometry, performance-based tests of strength and balance, medical history, medication use, smoking and alcohol use, and other parameters. Blood, urine, and DNA specimens have been archived for use in future studies of importance to the health of older men. In a subcohort of 3000 MrOS participants, we propose to add comprehensive and accurate assessments of sleep using in-home polysomnography, wrist actigraphy, questionnaires and other measures; and prospective adjudication of CVD events, to the extensive measures that have already been performed or planned in the MrOS cohort study. These new measures will enable us to test several important hypotheses: 1) to characterize the associations between sleep disruption and subsequent CVD events during 3.5 years of follow-up, 2) to determine if sleep disturbances are associated with an increased risk of total and cause-specific mortality in older men, 3) to test whether sleep disturbances are associated with increased risk of falls and decreased physical function, 4) to test whether sleep disturbances are associated with impaired cognitive function in older men, and 5) to test whether sleep disorders are associated with bone density and fracture risk in older men. We will also supplement the bank of MrOS specimens to allow for testing of future hypotheses concerning the role of sleep in the development of age-related diseases and conditions.

描述（由申请人提供）： 据估计，超过50％的65岁及以上的成年人报告了某些睡眠中断，而大约20％的人患有慢性失眠。 白天昏昏欲睡的主要原因是，据估计，有20-60％的老年人发生了阻塞性睡眠呼吸暂停，具体取决于所使用的定义和所研究的特定种群。 尽管老年人的睡眠障碍患病率很高，但对后果的研究相对较少。 大多数研究受到横截面设计的限制，样本量小或缺乏对睡眠的全面和客观评估。 拟议的研究是老年男性睡眠障碍的结果，它将利用已建立的队列，该队列已用于男性（MROS）研究中的骨质疏松性骨折（5U01AR045647-DR。ERICORWOLL，PI）。 MROS是一项为期7年的研究，于1999年7月开始，是一项多中心的前瞻性研究，对大约65名65岁及65岁以上的男性。 在MROS基线访问期间，收集了广泛的测量，包括身体成分和体内脂肪分布（通过DEXA和定量计算机断层扫描），骨密度，人体测定法，基于绩效的力量和平衡测试，病史，药物使用，药物使用，吸烟和酒精以及其他参数。 血液，尿液和DNA标本已被存档，以用于未来对老年男性健康重要性的研究。 在3000名MROS参与者的子病毒中，我们建议使用家庭多摄影，腕部行为，问卷调查和其他措施来增加对睡眠的全面评估；以及对CVD事件的前瞻性裁决，对在MROS队列研究中已经采取或计划的广泛措施。 这些新措施将使我们能够检验几个重要的假设：1）在3。5年的随访中表征睡眠中断与随后的CVD事件之间的关联，2）确定睡眠干扰是否与老年男性的总和特异性死亡的风险增加相关，3）与老年人的衰落相关，是否与降低的身体功能相关，是否与降低的身体相关，是否与降低的身体相关，是否与降低的身体相关，是否与4的障碍相关，是否与4个相关，是否与降低的良好相关，是否与4个相关的疾病，是否与4的良好相关，是否与4个相关的疾病，是否与4个相关的疾病，是否与4个相关的疾病，是否与降低的身体相关。 5）测试睡眠障碍是否与老年男性的骨密度和骨折风险有关。 我们还将补充MROS标本银行，以允许测试有关睡眠在与年龄相关疾病和状况发展中的作用的未来假设。