LOOKAHEAD STUDY

前瞻研究

• 批准号: 7606986
• 负责人: Edward Schurr Horton
• 金额: $ 32.06万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606986
• 关键词: Affect; Body Weight decreased; Cardiovascular Diseases; Cardiovascular system; Cessation of life; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Disease; Education; Energy Intake; Event; Exercise; Funding; Grant; Health; Institution; Intervention; Morbidity - disease rate; Myocardial Infarction; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Overweight; Randomized Clinical Trials; Relative (related person); Research; Research Personnel; Resources; Source; Stroke; United States National Institutes of Health; cardiovascular risk factor; cost; cost effectiveness; fitness; health related quality of life; lifestyle intervention; mortality; psychological outcomes; therapy design

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Look AHEAD (Action For Health in Diabetes) is a multicenter randomized clinical trial to examine the effects of a lifestyle intervention designed to achieve and maintain weight loss over the long term through decreased caloric intake and exercise. Look AHEAD is focusing on the disease most affected by overweight and obesity, type 2 diabetes, and on the outcome that causes the greatest morbidity and mortality, cardiovascular disease. The primary aim of Look AHEAD is to study the effects of the two interventions on major cardiovascular events: heart attack, stroke and cardiovascular-related death. Look AHEAD also will investigate the impact of the interventions on other cardiovascular disease-related outcomes, cardiovascular risk factors, and all-cause mortality. Additional outcomes include: diabetes control and complications, fitness, general health, health-related quality of life and psychological outcomes. The cost and cost effectiveness of the Lifestyle Intervention relative to Diabetes Support and Education will be assessed.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 Look AHEAD（糖尿病健康行动）是一项多中心随机临床试验，旨在检查生活方式干预的效果，该干预旨在通过减少热量摄入和运动来实现并长期维持体重减轻。 Look AHEAD 重点关注受超重和肥胖影响最严重的疾病、2 型糖尿病，以及导致最高发病率和死亡率的心血管疾病。 Look AHEAD 的主要目的是研究这两种干预措施对主要心血管事件的影响：心脏病发作、中风和心血管相关死亡。 Look AHEAD 还将调查干预措施对其他心血管疾病相关结局、心血管危险因素和全因死亡率的影响。其他结果包括：糖尿病控制和并发症、健身、总体健康、与健康相关的生活质量和心理结果。将评估与糖尿病支持和教育相关的生活方式干预的成本和成本效益。