MEAN A1C

平均 A1C

• 批准号: 7607003
• 负责人: Edward Schurr Horton
• 金额: $ 18.03万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607003
• 关键词: Biological Assay; Blood Glucose; Calibration; Clinical; Clinical Chemistry; Computer Retrieval of Information on Scientific Projects Database; Data; Diabetes Mellitus; Funding; Glycosylated hemoglobin A; Goals; Grant; Institution; International; Measurement; Methods; Observational Study; Range; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; glucose tolerance; glycemic control; type I and type II diabetes

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main goal of this multi-center observational study is to establish the relationship between Mean Blood Glucose (MBG) concentration and glycohemoglobin (HbA1c) values according to the Diabetes Control and Complications Trial (DCCT) and the International Federation of Clinical Chemistry (IFCC) method over a wide range of glycemic control in both Type 1 and Type 2 Diabetes. The ultimate goal, when the relationship has been confirmed, is to implement the calculated MBG as the means of expressing HbA1c results and use the IFCC-HbA1c to standardize HbA1c assays. The main hypothesis to be tested is that standardized measurements of HbA1c can be used to accurately estimate mean blood glucose concentrations during the preceding two to three months over a wide range of DCCT HbA1c values (4-6.5%, 6.6-8.5% and > 8.5%) in subjects with either Type 1 or Type 2, normal glucose tolerance and of various racial and/or ethnic backgrounds. A secondary aim is to develop predictive formulas from the calibration data that are generated from this study that will allow HbA1c data to be expressed in terms of MBG values in clinical practice.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项多中心观察性研究的主要目的是建立根据糖尿病控制和并发症试验（DCCT）（DCCT）的平均血糖（MBG）浓度（MBG）浓度（HBA1C）值之间的关系，而国际临床化学联盟（IFCC）在两种类型1型和类型2型号的临床范围内的临床化学联盟（IFCC）方法（IFCC）方法。确认关系的最终目标是实施计算出的MBG作为表达HBA1C结果的手段，并使用IFCC-HBA1C标准化HBA1C分析。 要测试的主要假设是，在前两到三个月的DCCT HBA1C值（4-6.5％，6.6-8.5％和> 8.5％）中，HBA1C的标准化测量可用于准确估计平均血糖浓度。第二个目的是从这项研究产生的校准数据中开发预测公式，这些公式将允许HBA1C数据在临床实践中以MBG值表示。