VCRC LONGITUDINAL STUDY FOR POLYARTERITIS NODOSA

VCRC 结节性多动脉炎的纵向研究

• 批准号: 7606278
• 负责人: Peter A Merkel
• 金额: $ 0.38万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606278
• 关键词: Biological Markers; Blood; Chemicals; Clinical; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Gene Proteins; Grant; Institution; Laboratory Finding; Laboratory Research; Longitudinal Studies; Measures; Medical History; Methods; Patients; Pharmaceutical Preparations; Physical Examination; Polyarteritis Nodosa; Purpose; Research; Research Personnel; Resources; Risk; Source; Specimen; Test Result; Time; United States National Institutes of Health; Urine; Vasculitis; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to use new scientific methods to discover new biological markers (biomarkers) of disease activity in patients with Polyarteritis Nodosa that will serve one or more of the following uses: i) measure the amount of active disease occurring at any given time; ii) predict what types of problems patients are at risk for in order to help choose the best therapy; and iii) predict whether patients will respond to specific treatments. To help discover these new markers, we will follow a large group of patients with Polyarteritis Nodosa at Vasculitis Clinical Research Consortium Vasculitis Centers over several years. Clinical information and blood and urine specimens will be collected on a regular basis. The types of information collected will include medical history details, medication use, physical examination findings, and laboratory and other test results. Blood and urine specimens will be sent to research laboratories that are looking to discover new proteins, genes, and other chemicals that could serve as new biomarkers

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是使用新的科学方法来发现结节性多动脉炎患者疾病活动的新生物标志物（生物标志物），这些标志物将用于以下一种或多种用途：i）测量在任何给定的情况下发生的活动性疾病的数量时间; ii) 预测患者面临哪些类型的问题风险，以帮助选择最佳治疗方法； iii) 预测患者是否会对特定治疗产生反应。 为了帮助发现这些新标记物，我们将在血管炎临床研究联盟血管炎中心对一大群结节性多动脉炎患者进行数年跟踪。将定期收集临床信息以及血液和尿液样本。收集的信息类型包括病史详细信息、药物使用情况、体检结果以及实验室和其他测试结果。血液和尿液样本将被送往研究实验室，寻找新的蛋白质、基因和其他可作为新生物标志物的化学物质