Pre- and postnatal chemical mixture exposure, adolescent sleep health, and allostatic load

产前和产后化学混合物暴露、青少年睡眠健康和稳态负荷

基本信息

批准号：
10639218
负责人：
Clara G Sears
金额：
$ 56.24万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-12 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10639218
关键词：
Adolescence Adolescent Adolescent Development Adrenal Glands Adult Age Biological Biological Markers Biometry Birth Body Composition Cardiovascular system Catecholamines Characteristics Chemicals Child Childhood Cortisone Data Development Diet Disease Enrollment Environment Environmental Exposure Environmental Health Environmental Risk Factor Epidemiology Exposure to Foundations Glycoproteins Goals Growth Hair Health Homeostasis Hydrocortisone Hypertension Hypothalamic structure Immune Individual Infant Inflammation Intervention Joints Knowledge Life Link Longitudinal Studies Longitudinal cohort Measures Metabolic Metals Middle School Student Morbidity - disease rate Neurobiology Neurosecretory Systems Obesity Outcome Outcome Measure Pathway interactions Persons Physiological Pituitary Gland Pituitary-Adrenal System Poly-fluoroalkyl substances Predisposition Pregnancy Pregnant Women Process Prospective cohort Questionnaires Regulation Research Risk Risk Factors Risk Reduction School-Age Population Serum Shapes Sleep System Testing Toxic Environmental Substances Toxicant exposure Visit actigraphy adequate sleep allostasis allostatic load blood pressure elevation cardiometabolism cardiovascular disorder risk cardiovascular health cardiovascular risk factor cohort consumer product critical developmental period design early childhood early life exposure environmental chemical high school improved improvement on sleep indexing infancy modifiable risk mortality multidisciplinary neurobiological mechanism neurodevelopment neurotoxic novel phthalates pollutant poor sleep postnatal pregnant prenatal prospective public health intervention sleep health sleep quality systemic inflammatory response toxic metal toxicant urinary

项目摘要

PROJECT SUMMARY / ABSTRACT A majority of U.S. adolescents are not getting sufficient sleep for optimal health. Sleep health is critical during adolescence because of rapid neurodevelopment, growth, and body composition changes. Moreover, inadequate and poor-quality sleep can increase allostatic load, or cumulative physiological ‘wear and tear’, from disruptions across multiple regulatory systems that coordinate immune, cardiovascular, and metabolic function. Evidence indicates that developmental exposures to ubiquitous environmental toxicants may disrupt neurobiological mechanisms that regulate sleep and allostasis. However, whether these exposures are modifiable risk factors for poor sleep during adolescence has not been rigorously examined. Our multidisciplinary project brings together experts in pediatric environmental health, sleep, and cardiometabolic health to identify whether early life exposure to environmental toxicant mixtures disrupts adolescent sleep health and increases allostatic load. This project focuses on mixtures of phthalates, per-/polyfluoroalkyl substances (PFAS), and metals. Most pregnant people, infants, and children are exposed to mixtures of these toxicants through diet and consumer goods. The project leverages existing and new data from two well-characterized prospective pregnancy and birth cohorts, the Health Outcomes and Measures of the Environment (HOME) Study and the Maternal-Infant Research on Environmental Chemicals (MIREC) Study. Both cohorts previously enrolled pregnant women and followed children until ages 7-9 (MIREC n=300) or 10-12 (HOME n=256) years with additional visits underway at ages 10-12 (MIREC) and 16-18 (HOME) years. Sleep characteristics will be examined at two timepoints in both cohorts using actigraphy. We will quantify relations between environmental toxicant biomarkers during gestation, early childhood, school age, and adolescence with sleep characteristics (Aim 1) and allostatic load (Aim 2) during adolescence. We will also examine whether exposure to environmental toxicant mixtures is associated with hypothalamus-pituitary-adrenal (HPA) activity, catecholamines, and systemic inflammation, biological intermediates of sleep-wake regulation and allostasis (Aim 3). Our analyses will identify individual and joint effects of environmental toxicant mixtures and examine periods of heightened susceptibility during critical developmental periods. Identifying modifiable environmental factors that contribute to poor sleep health and allostatic load may inform novel interventions to reduce the risk of cardiovascular disease, the leading cause of morbidity and mortality in adulthood worldwide.

项目摘要 /摘要大多数美国青少年没有足够的睡眠来获得最佳健康。睡眠健康至关重要青少年由于神经发育，生长和身体成分的快速变化。而且，不足和质量不足的睡眠会增加同性恋负荷或累积的生理“磨损” 多个调节系统的破坏，这些调节系统是协调免疫学，心血管和代谢功能的。证据表明，发育性暴露于无处不在的环境有毒物质可能会破坏调节睡眠和同性恋的神经生物学机制。但是，这些暴露是青少年期间睡眠不佳的可修改风险因素尚未进行严格检查。我们的多学科项目汇集了儿科环境健康，睡眠和心脏代谢健康方面的专家早期生命暴露于环境有毒物质混合物是否会破坏青少年睡眠健康并增加同级负载。该项目的重点是邻苯二甲酸盐，每/多氟烷基物质（PFA）和金属。大多数孕妇，婴儿和儿童都会通过饮食和消费品。该项目利用两个特征良好的潜在的现有数据和新数据怀孕和出生队列，环境的健康成果和措施（家庭）研究和孕产妇环境化学研究（MIREC）研究。两个队列先前均已注册孕妇并跟随儿童直到7-9岁（MIREC n = 300）或10-12（家庭n = 256）年在10-12岁（MIREC）和16-18岁（家庭）年的额外访问中。睡眠特征将是使用行为摄影在两个队列中的两个时间点检查。我们将量化环境之间的关系妊娠，童年，学龄和青少年的毒物生物标志物具有睡眠特征（AIM 1）和Allostatic载荷（AIM 2）在青少年期间。我们还将检查是否接触环境毒物混合物与下丘脑 - 垂体 - 肾上腺（HPA）活性，儿茶酚胺和系统性炎症，睡眠效果调节的生物学中间体和同性恋（AIM 3）。我们的分析将确定环境有毒物质的个人和关节作用，并检查了增长的时期关键发育时期的敏感性。确定可改变的环境因素对于睡眠不良和同性恋负荷可能会导致新颖的干预措施，以降低心血管的风险疾病，是全球成年期发病和死亡率的主要原因。