CARDIAC DISEASE IN CENTENARIAN OFFSPRING

百岁后代的心脏病

• 批准号: 7606253
• 负责人: DELLARA F. TERRY
• 金额: $ 2.15万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606253
• 关键词: Age; Aging; Cardiovascular Diseases; Centenarian; Child; Computer Retrieval of Information on Scientific Projects Database; Disease; Funding; Grant; Health; Heart Diseases; Individual; Institution; Life; Life Expectancy; Longevity; Modeling; Parents; Rate; Research; Research Personnel; Resources; Risk Factors; Source; Time; United States National Institutes of Health; age related; healthy aging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Centernarians, individuals who live to age 100, live the vast majority of their lives in good health. In many ways, these individuals are models of successful aging; however, by the time they reach 100, many of them have developed age-related diseases that they have avoided for the majority of their lives. Unlike their parents, the children of centenarians, who are in their 70s and 80s, are generally not near the end of their lives and may better reflect what it takes to make it to exceptional old age. Dr. Dellara Terry studies the children of centenarians in order to gain a better understanding of healthy aging and longevity. Her preliminary results suggest that the children of centenarians may be following in the footsteps of their parents. In particular, the centenarian children have lower rates of heart disease and fewer risk factors associated with heart disease when they are compared to individuals whose parents died at the average life expectancy. Given these differences and evidence regarding the familiality of longevity, Dr. Terry hypothesizes that the centenarian children are predisposed to longevity by delaying or avoiding cardiovascular disease and its risk factors.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 中年人，即活到 100 岁的人，一生中的大部分时间都身体健康。从很多方面来说，这些人都是成功老龄化的典范。然而，到了 100 岁的时候，他们中的许多人都患上了与年龄相关的疾病，而这些疾病是他们一生中一直在避免的。与他们的父母不同，百岁老人的孩子年龄在 70 多岁和 80 多岁，通常还没有接近生命的终点，可能更能反映如何才能活到高龄。 德拉拉·特里博士研究百岁老人的孩子，以便更好地了解健康老龄化和长寿。她的初步结果表明，百岁老人的孩子可能会追随父母的脚步。特别是，与父母在平均预期寿命期间去世的人相比，百岁老人的心脏病发病率较低，与心脏病相关的危险因素也较少。鉴于这些差异和有关长寿家族性的证据，特里博士推测，百岁儿童通过延迟或避免心血管疾病及其危险因素而倾向于长寿。