Genetics of Cardiac Disease in Centenarian Offspring

百岁后代心脏病的遗传学

基本信息

批准号：
6792135
负责人：
DELLARA F. TERRY
金额：
$ 15.91万
依托单位：
BOSTON MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-01 至 2008-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6792135
关键词：
aging cardiovascular disorder cardiovascular disorder risk centenarian human (100+)clinical research family genetics gene environment interaction genetic disorder genetic polymorphism genotype human middle age (35-64)human old age (65+)human subject

项目摘要

DESCRIPTION (provided by applicant): Centenarian children (c-children) offer a unique opportunity to learn more about the aging process. For the past four years Dr. Terry has done research on the differences between the children of centenarians (c-children) and a control group whose parents died at an average life expectancy. Preliminary results from Dr. Terry's work suggest that the c-children have a lower prevalence of cardiovascular disease, hypertension and diabetes compared to controls. Given these differences and evidence regarding the familiality of longevity, Dr. Terry hypothesizes that the c-children are predisposed to longevity by delaying or avoiding cardiovascular disease and its risk factors. The first specific aim of this study is to compare the cardiovascular health of the c-children and controls whose parents died at an average life expectancy with disease prevalence measures, clinical measures of vascular function and stiffness, and measures of markers of inflammation. The second specific aim of this study is to determine whether polymorphisms in candidate genes related to cardiovascular disease differ between the two groups. While Dr. Terry's work initially involved phenotyping the two groups, it increasingly involves genetic analysis of the two groups, an area in which Dr. Terry has had little formal training. In order to become an independent research scientist in this field, Dr. Terry seeks support to take courses in genetic epidemiology and molecular genetics. She also proposes to spend 20% of her time working with Dr. Lindsay Farrer, the Chief of the Genetics Program at Boston University Medical Center, and his genetics team. In addition to learning genetic epidemiological research methodologies, Dr. Terry proposes to collaborate with Dr. Emelia Benjamin, Director of the Echocardiography Laboratory and the Vascular Testing Laboratory at the Framingham Heart Study, to advance her understanding of cardiovascular epidemiology. Finally she proposes to attend and present her data at national genetics, geriatrics, and cardiology meetings. The above activities will not only provide Dr. Terry with a greater knowledge of genetic and cardiovascular epidemiology but also the opportunity to collaborate with others in the field. Dr. Terry will use the knowledge gained from didactic instruction and mentored research experience in aging, genetic epidemiology, molecular genetics, and cardiovascular epidemiology to develop her career as an independent researcher in aging and genetic epidemiology. Her goal from the five years of career development proposed in this application is to gain the skills necessary to successfully direct the genetic epidemiological aspects of the NECS and eventually her own independently funded studies.

描述（由申请人提供）：百岁儿童（c-children）提供了一个独特的机会来了解更多关于衰老过程的信息。在过去的四年里，特里博士研究了百岁老人的孩子（c-孩子）和父母按平均预期寿命去世的对照组之间的差异。特里博士工作的初步结果表明，与对照组相比，c 代儿童患心血管疾病、高血压和糖尿病的患病率较低。鉴于这些差异以及有关长寿家族性的证据，特里博士推测，c 代儿童通过延迟或避免心血管疾病及其危险因素而倾向于长寿。这项研究的第一个具体目的是将 c 岁儿童和父母在平均预期寿命下死亡的对照组的心血管健康状况与疾病患病率指标、血管功能和硬度的临床指标以及炎症标志物指标进行比较。本研究的第二个具体目的是确定两组之间与心血管疾病相关的候选基因的多态性是否存在差异。虽然特里博士的工作最初涉及对这两个群体进行表型分析，但它越来越多地涉及这两个群体的遗传分析，而特里博士在这一领域几乎没有接受过正式培训。为了成为该领域的独立研究科学家，特里博士寻求支持来学习遗传流行病学和分子遗传学课程。她还提议花 20% 的时间与波士顿大学医学中心遗传学项目负责人 Lindsay Farrer 博士及其遗传学团队合作。除了学习遗传流行病学研究方法外，Terry 博士还建议与弗雷明汉心脏研究中心超声心动图实验室和血管测试实验室主任 Emelia Benjamin 博士合作，以增进她对以下疾病的理解：心血管流行病学。最后，她提议参加全国遗传学、老年病学和心脏病学会议并展示她的数据。上述活动不仅将使特里博士对遗传和心血管流行病学有更多的了解，而且还将有机会与该领域的其他人合作。特里博士将利用从衰老、遗传流行病学、分子遗传学和心血管流行病学方面的教学指导和指导研究经验中获得的知识，发展她作为衰老和遗传流行病学独立研究员的职业生涯。她在本申请中提出的五年职业发展目标是获得成功指导 NECS 遗传流行病学方面所需的技能，并最终完成她自己独立资助的研究。