Centenarian Offspring and Vascular Disease Resistance

百岁后代与血管疾病抵抗力

• 批准号: 7116385
• 负责人: DELLARA F. TERRY
• 金额: $ 21.49万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7116385
• 关键词: aging; biomarker; cardiovascular disorder epidemiology; cardiovascular disorder risk; cardiovascular function; centenarian human (100+); clinical research; family genetics; gene frequency; genetic polymorphism; human subject; patient oriented research; training

DESCRIPTION (provided by applicant): Centenarian offspring (c-offspring) offer a unique opportunity to learn more about the aging process. For the past seven years Dr. Terry has conducted research on the differences between c-offspring and a comparison group whose parents died at an average life expectancy. Preliminary results from her work suggest that the c-offspring have a lower prevalence of cardiovascular disease, hypertension and diabetes compared to the comparison group. Given these differences and evidence regarding the familiarity of longevity, she hypothesizes that coffspring are predisposed to longevity by delaying or avoiding cardiovascular disease and its risk factors. The specific aims of this proposed study are to enroll an adequate sample of c-offspring and two comparison groups (one as described above and a second group consisting of spouses of c-offspring) with which to compare cardiovascular health using measures of disease prevalence, vascular function, and biomarkers. In addition, this study aims to determine whether frequencies of polymorphisms in candidate genes related to cardiovascular disease differ among the c-offspring and the two comparison groups. Dr. Terry's research initially involved the phenotypic characterization of individuals who age well with minimal disease burden. Findings have led to the likelihood and the need for investigating genetic associations. In order to become an independent research scientist in aging and genetic epidemiology, Dr. Terry seeks support to spend 10% of her time with her sponsors, Drs. Perls, Silliman, and Benjamin, to advance her knowledge in the design of epidemiological studies of aging and cardiovascular disease. In addition, she proposes to spend 10% of her time working with Dr. Farrer and his genetics team. She also proposes to take courses in genetic and cardiovascular epidemiology, and statistical genetics. Finally, she proposes to attend and present her data at national geriatrics, genetics, and the annual Beeson meetings. The above activities will not only provide Dr. Terry with a greater knowledge of aging, genetics and cardiovascular epidemiology, but also the opportunity to perform multidisciplinary research with collaborators in geriatrics, genetics and other disciplines. Dr. Terry will use the knowledge gained from didactic instruction and mentored research to develop her career as an independent researcher in aging and genetic epidemiology. Her goal from the three years of career development proposed in this Beeson application is to gain the skills necessary to successfully direct the genetic epidemiological aspects of the New England Centenarian Study as well as her own independently funded studies.

描述（由申请人提供）：百岁后代（c-offspring）提供了一个独特的机会来了解更多关于衰老过程的信息。在过去的七年里，特里博士对同卵后代和父母在平均预期寿命下去世的对照组之间的差异进行了研究。她的工作的初步结果表明，与对照组相比，双胞胎后代的心血管疾病、高血压和糖尿病患病率较低。考虑到这些差异以及有关长寿的熟悉程度的证据，她推测后代通过延迟或避免心血管疾病及其危险因素而倾向于长寿。 这项拟议研究的具体目的是招募足够的同系后代样本和两个对照组（一组如上所述，第二组由同系后代的配偶组成），利用疾病患病率的衡量标准来比较心血管健康状况，血管功能和生物标志物。此外，本研究旨在确定与心血管疾病相关的候选基因的多态性频率在后代和两个对照组之间是否存在差异。 特里博士的研究最初涉及疾病负担最小的老年患者的表型特征。这些发现导致了研究遗传关联的可能性和必要性。为了成为衰老和遗传流行病学领域的独立研究科学家，Terry 博士寻求支持，花 10% 的时间与她的资助者 Drs. 在一起。 Perls、Silliman 和 Benjamin，以提高她在衰老和心血管疾病流行病学研究设计方面的知识。此外，她提议花 10% 的时间与 Farrer 博士和他的遗传学团队一起工作。她还建议学习遗传和心血管流行病学以及统计遗传学课程。最后，她提议参加全国老年病学、遗传学和年度比森会议并展示她的数据。上述活动不仅将使Terry博士对衰老、遗传学和心血管流行病学有更多的了解，而且有机会与老年病学、遗传学和其他学科的合作者进行多学科研究。 特里博士将利用从教学和指导研究中获得的知识来发展她作为衰老和遗传流行病学独立研究员的职业生涯。她在比森申请中提出的三年职业发展目标是获得成功指导新英格兰百岁老人研究以及她自己独立资助的研究的遗传流行病学方面所需的技能。