HEPATIC CARBOHYDRATE METABOLISM IN THE YOUNG AND ELDERLY

年轻人和老年人的肝脏碳水化合物代谢

• 批准号: 7606325
• 负责人: JEFFREY D BROWNING
• 金额: $ 0.04万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606325
• 关键词: Aging; Body Weight; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Diabetes Mellitus; Elderly; Fasting; Funding; Glucose; Grant; Hepatic; Human; Individual; Institution; Insulin Resistance; Liver; Metabolic Diseases; Metabolism; Physical activity; Predisposition; Research; Research Personnel; Resources; Secondary to; Source; United States National Institutes of Health; blood glucose regulation; carbohydrate metabolism; glucose output; glucose production; impaired glucose tolerance

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The hypothesis of this study is that glucose output by the liver increases with advancing age secondary to hepatic insulin resistance, independent of body weight or level of physical activity, thus leading to a predisposition of elderly individuals to develop diabetes mellitus or impaired glucose tolerance. The aims of this study are: 1) to quantify hepatic glucose output under fasting conditions in both younger and older humans in order to understand the changes in glucose homeostasis associated with aging. 2) to determine the substrate sources for glucose synthesis in the liver and correlate this data with hepatic glucose production as a means of detecting the alterations in intermediary metabolism that may underlie metabolic diseases, such as diabetes mellitus, that are associated with advancing age.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的假设是，肝脏的葡萄糖输出随着肝胰岛素抵抗的增长而增加，与体重或身体活动水平无关，从而导致老年人患糖尿病或葡萄糖耐受性受损。 这项研究的目的是： 1）在禁食条件下，在年轻人和年龄较大的人群中量化肝葡萄糖输出，以了解与衰老相关的葡萄糖稳态的变化。 2）确定肝脏中葡萄糖合成的底物来源，并将这些数据与肝葡萄糖的产生相关联，作为检测中介代谢的改变，这些代谢的改变，这些代谢可能是与糖尿病相关的代谢性疾病的基础，这些疾病（如糖尿病）与促进年龄相关。