RODENT IMAGING AND SPECTROSCOPY FACILITY

啮齿动物成像和光谱学设施

• 批准号: 8171643
• 负责人: KIM KANGASNIEMI
• 金额: $ 0.52万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8171643
• 关键词: Aging; Anesthesia procedures; Animals; Arts; Body fat; Cardiac; Chemical Shift Imaging; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Data; Development; Diffusion Magnetic Resonance Imaging; Diffusion weighted imaging; EFRAC; Electrocardiogram; Eligibility Determination; Fatty acid glycerol esters; Funding; Grant; Image; Institution; Ischemia; Lesion; Longitudinal Studies; Magnetic Resonance; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Metabolism; Modeling; Monitor; Mus; Perfusion; Phenotype; Physiology; Protons; Rattus; Research; Research Personnel; Resources; Rodent; Source; Spectrum Analysis; Temperature; Tissues; United States National Institutes of Health; Weight; angiogenesis; heart motion; image processing; imaging modality; in vivo; instrument; research study; respiratory; tool; tumor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Magnetic Resonance is a useful tool for in vivo studies in mouse and rat models. Two instrument were installed recently. The Mouse MRI Core Facility offers state-of-the-art magnetic resonance imaging (MRI) and proton spectroscopy (MRS) of mice and other small animals to all campus investigators. Mice can be delivered to our facility in the Clements Imaging building (NE) on the North campus, imaged under anesthesia, and returned to the investigator the same day. The facility includes a 7 Tesla horizontal-bore magnet and various physiology monitoring capabilities including ECG, respiratory gating for cardiac imaging and temperature monitoring and control throughout the imaging experiment. The facility will provide guidance for post-processing of image data and experimental planning for longitudinal studies. The mouse MR facility has developed screening protocols to optimize animal throughput including MR imaging methods: T1, T2, Proton Weighted Imaging, Gd-T1 weighted imaging Dynamic Contrast Enhanced MRI Diffusion-Weighted Imaging (DWI) / Diffusion-Tensor Imaging (DTI) MR Spectroscopy: Single Voxel Spectroscopy CSI-Chemical Shift Imaging Various applications that we can provide expertise in are listed here, but not limited to Anatomical MR Imaging: * Normal development / aging * Detection/Monitoring of lesions (tumor, ischemia, etc.) * Body fat distribution * Phenotyping Functional MR Imaging: * Perfusion (angiogenesis, etc.) * Cardiac motion/Ejection fraction * Magnetic Resonance Angiography (MRA) Tissue Metabolism: * Fat metabolites * Characterization of tumors

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 磁共振是小鼠和大鼠模型中体内研究的有用工具。最近安装了两个乐器。 小鼠和其他小动物的小鼠MRI MRI核心设施为所有校园研究人员提供了最先进的磁共振成像（MRI）和质子光谱（MRS）。可以将小鼠在北部校园的Clements Imaging Building（NE）的设施中送到我们的设施，并在麻醉下成像，并于当天返回调查员。该设施包括7特斯拉水平孔磁铁和各种生理监测能力，包括ECG，用于心脏成像的呼吸门控以及整个成像实验过程中的温度监测和控制。该设施将为纵向研究的图像数据和实验计划提供指导。鼠标MR设施已经开发了筛查方案，以优化动物吞吐量 MR成像方法： T1，T2，质子加权成像，GD-T1加权成像 动态对比增强了MRI 扩散加权成像（DWI） /扩散诱变成像（DTI） MR光谱学： 单素光谱 CSI化学移位成像 我们可以提供的各种专业知识在此处列出，但不限于 解剖学先生成像： *正常发展 /老化 *病变的检测/监测（肿瘤，缺血等） *体内脂肪分布 *表型 功能性MR成像： *灌注（血管生成等） *心脏运动/射血分数 *磁共振血管造影（MRA） 组织代谢： *脂肪代谢产物 *肿瘤的表征