CARBON MONOXIDE SCREENING IN PREANESTHETIC CHILDREN

麻醉前儿童的一氧化碳筛查

• 批准号: 7605079
• 负责人: ROBERT FRIESEN
• 金额: $ 3.25万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7605079
• 关键词: Adult; Blood; Carbon Monoxide; Carboxyhemoglobin; Child; Computer Retrieval of Information on Scientific Projects Database; Cotinine; Coughing; Devices; Disadvantaged; Environmental Tobacco Smoke; Exhalation; Exposure to; Funding; Grant; Institution; Invasive; Laryngismus; Measures; Oxygen; Research; Research Personnel; Resources; Risk; Screening procedure; Source; Teenagers; Testing; United States National Institutes of Health; cigarette smoking; respiratory; sensor; tool; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Exposure to environmental tobacco smoke (ETS) is associated with an increased risk of perianesthetic respiratory complications in children, including laryngospasm, severe coughing, breath holding, oxygen desaturation, and increased oxygen requirement. A quantitative screening tool for ETS in children is desirable because historical screening is inaccurate and unreliable. Some quantitative tests have disadvantages that make them poor screening tools. Blood carboxyhemoglobin levels require an invasive blood draw. Urinary cotinine concentration is accurate and correlates well with ETS, but takes too long to perform to be used as a screening device. Exhaled (end-tidal) carbon monoxide (CO) can be accurately measured by a handheld, battery powered, electrochemical sensor device and correlates well with amount of cigarette smoking in teenagers and adults. As a screening tool, exhaled CO has benefits of being noninvasive, simple, and immediate. We propose to evaluate exhaled CO as a screening tool for exposure to ETS in preanesthetic children.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 暴露于环境烟草烟雾 (ETS) 与儿童麻醉周围呼吸道并发症的风险增加相关，包括喉痉挛、严重咳嗽、屏气、氧饱和度降低和需氧量增加。 儿童 ETS 的定量筛查工具是可取的，因为历史筛查不准确且不可靠。 一些定量测试的缺点使其成为较差的筛选工具。 血液碳氧血红蛋白水平需要侵入性抽血。 尿可替宁浓度准确且与 ETS 相关性良好，但用作筛查设备需要很长时间。 呼出（潮气末）一氧化碳 (CO) 可以通过手持式、电池供电的电化学传感器设备进行精确测量，并且与青少年和成人的吸烟量密切相关。 作为一种筛查工具，呼出一氧化碳具有无创、简单、即时的优点。 我们建议评估呼出的 CO 作为麻醉前儿童 ETS 暴露的筛查工具。