CARBON MONOXIDE SCREENING IN PREANESTHETIC CHILDREN

麻醉前儿童的一氧化碳筛查

• 批准号: 7374352
• 负责人: ROBERT FRIESEN
• 金额: $ 9.5万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-24 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374352
• 关键词: blood; carbon monoxide; carboxyhemoglobin; children; nicotine; oxygen; passive smoking; respiratory reflex; smoking; tobacco abuse

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Exposure to environmental tobacco smoke (ETS) is associated with an increased risk of perianesthetic respiratory complications in children, including laryngospasm, severe coughing, breath holding, oxygen desaturation, and increased oxygen requirement. A quantitative screening tool for ETS in children is desirable because historical screening is inaccurate and unreliable. Some quantitative tests have disadvantages that make them poor screening tools. Blood carboxyhemoglobin levels require an invasive blood draw. Urinary cotinine concentration is accurate and correlates well with ETS, but takes too long to perform to be used as a screening device. Exhaled (end-tidal) carbon monoxide (CO) can be accurately measured by a handheld, battery powered, electrochemical sensor device and correlates well with amount of cigarette smoking in teenagers and adults. As a screening tool, exhaled CO has benefits of being noninvasive, simple, and immediate. We propose to evaluate exhaled CO as a screening tool for exposure to ETS in preanesthetic children.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。暴露于环境烟草烟雾（ETS）与儿童过周期呼吸并发症的风险增加有关，包括喉部，严重的咳嗽，呼吸，呼吸，氧气去饱和和氧气需求增加。对于儿童中ET的定量筛查工具是可取的，因为历史筛查是不准确和不可靠的。一些定量测试的缺点使它们成为较差的筛查工具。血羧基血红蛋白水平需要侵入性的血液抽血。尿型可替氨酸浓度是准确的，并且与ETS良好相关，但需要花费太长时间才能用作筛查装置。可以通过手持式，电池供电，电化学传感器设备来准确测量一氧化碳（CO）（CO），并与青少年和成人吸烟量很好地测量。作为筛选工具，Exhaled Co具有无创，简单和直接的好处。我们建议评估呼出的CO作为筛查工具，以暴露于预觉儿童中的ETS。