Accuracy and Feasibility of Non-Invasive Anemia Screening Assistant (ASIST) Device in Resource-Limited Settings

资源有限环境中非侵入性贫血筛查辅助 (ASIST) 设备的准确性和可行性

基本信息

批准号：
10575222
负责人：
Allison Judkins
金额：
$ 22.78万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-01 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10575222
关键词：
12 year old Adolescent Adult Affect Africa Age Anemia Asia Attention Blood Blood Tests Carbon Monoxide Child Chronic Classification Clinical Color Community Health Community Health Aides Country Data Decision Making Development Devices Diagnosis Diagnostic Disease Evaluation Exhalation Feasibility Studies Female Adolescents Fetus Government Health Health care facility Hemoglobin Hemoglobin concentration result Hemolytic Anemia Incidence India Infant Iron Low Birth Weight Infant Maternal Mortality Measurement Measures Methods Morbidity - disease rate Mothers Non-Invasive Detection Nutritional Outcome Patient Recruitments Patients Perception Physical Examination Population Predictive Value Pregnancy Pregnant Women Premature Birth Prevalence Process Provider Public Health Reference Standards Resource-limited setting Resources Running Rural Skin Skin Pigmentation Small for Gestational Age Infant Specificity Surveys System Testing Training Validation Variant Visual Vulnerable Populations acceptability and feasibility antenatal care brain metabolism burden of illness clinical decision-making clinically relevant combat cost diagnostic tool effective therapy feasibility testing health economics high risk improved in vivo instrument low and middle-income countries maternal risk minimally invasive mortality novel patient population point of care portability pregnant teen productivity loss screening screening program standard of care tertiary care tool

项目摘要

Project Summary Validation and Feasibility Non-Invasive Anemia Diagnostic Tool (ASIST Device) This project will establish the accuracy and feasibility of our novel non-invasive, portable, low- cost device to diagnose chronic nutritional and hemolytic anemia in resource poor areas. This device has the potential to mitigate the prevalence of anemia in LMICs, improving health outcomes, especially in pregnant women and adolescent girls. Despite increased attention from the WHO, anemia continues to be a formidable public health issue affecting a third of the world's population, with much of the disease burden in low- and middle- income countries (LMICs). Pregnant women and young children are the most vulnerable of these populations. Severe anemia in pregnancy contributes significantly to preventable morbidity and mortality both during pregnancy and in the delivery process. For the fetus of an anemic mother, there are long-term neurodevelopmental consequences. In resource-rich countries, anemia can be diagnosed using minimally invasive point of care devices and nutritional and hemolytic causes can be differentiated without invasive testing using exhaled Carbon Monoxide, a breakdown product of hemoglobin. In low- and middle-income countries (LMICs), where this type of testing is not readily available, the diagnosis of anemia is often inaccurate or missed all together. Based on the global burden of anemia, especially in LMICs, there is a need for a low-cost device that can non-invasively detect anemia and help to distinguish between nutritional and hemolytic causes to inform clinical decision making.

项目摘要验证和可行性非侵入性贫血诊断工具（ASIST设备）该项目将确定我们新颖的非侵入性，便携式，低 - 的准确性和可行性在资源贫困地区诊断慢性营养和溶血性贫血的成本装置。这设备有可能减轻LMIC中贫血的患病率，从而改善健康状况结果，特别是在孕妇和青少年女孩中。尽管WHO的关注越来越大，但贫血仍然是一种强大的公共卫生影响世界三分之一人口的问题，在低和中收入国家（LMIC）。孕妇和幼儿是最脆弱的这些人群。怀孕的严重贫血对可预防的贡献很大怀孕期间和分娩过程中的发病率和死亡率。对于胎儿贫血的母亲，存在长期的神经发育后果。在资源丰富的国家，可以使用微创的护理点诊断贫血可以在不使用侵入性测试的情况下区分设备，营养和溶血性原因呼气的一氧化碳，血红蛋白的分解产物。在低收入和中等收入中国家（LMIC），这种类型的测试不容易获得，贫血的诊断是通常在一起或错过所有人。基于贫血的全球负担，尤其是 LMIC，需要一种低成本的设备，该设备可以非侵入性检测贫血并有助于区分营养和溶血性原因，以告知临床决策。