Periodontal Infections and Type 2 Diabetes Mellitus Risk

牙周感染和 2 型糖尿病风险

• 批准号: 7655283
• 负责人: Ryan T. Demmer
• 金额: $ 9万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7655283
• 关键词: Academic Medical Centers; Address; Age; Antibodies; Area; Beta Cell; Bioinformatics; Blood Cells; Cardiovascular Diseases; Cell physiology; Cells; Chronic; Chronic Disease; Communities; Data; Development; Diabetes Mellitus; Diet; Disease; Enrollment; Epidemiology; Ethnic Origin; Exposure to; Faculty; Functional disorder; Funding Mechanisms; Future; Gender; Gene Expression; Genomics; Grant; Health; Homeostasis; Impaired fasting glycaemia; Incidence; Infection; Infectious Agent; Inflammation; Inflammatory Response; Insulin; Insulin Resistance; Knowledge; Link; Lipids; Measurement; Mediating; Mediator of activation protein; Mentors; Methods; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Participant; Pathology; Periodontal Diseases; Periodontal Infection; Phase; Population; Positioning Attribute; Pregnancy Outcome; Principal Investigator; Process; Public Health; Public Health Schools; Publications; Reporting; Research; Research Design; Research Personnel; Research Project Grants; Research Proposals; Risk; Risk Factors; Role; Scientific Advances and Accomplishments; Smoking; Systemic disease; Testing; Time; Training; Woman; Writing; aged; blood glucose regulation; career development; case control; cohort; design; diabetes risk; fasting glucose; fasting plasma glucose; follow-up; impaired glucose tolerance; interest; men; pathogen; population based; time use

DESCRIPTION (provided by applicant): This career development proposal aims to provide the necessary protected research time and training for Dr. Demmer to transition from his postdoctoral research position to an independent tenure track faculty position. The proposal is comprised of two phases: 1) A mentored phase focused on strengthening the candidate's publication record and obtaining additional training in research areas outside of the candidate's current expertise; and 2) a comprehensive research project to be carried out upon procurement of a research track faculty position. The proposed training will be carried out in the Mailman School of Public Health at Columbia University Medical Center. Specifically, the mentored postdoctoral phase will provide opportunities for advanced training in the following four modules: Module 1) Advanced measurement methods with focus on methodological approaches to quantifying infection as an etiologic exposure for chronic disease; Module 2) Type 2 diabetes mellitus epidemiology and pathophysiology; Module 3) Genomics, with an emphasis in bioinformatics and gene expression studies; Module 4) Dissemination of scientific findings and grant writing. The independent phase research aims to test the hypothesis that periodontal infection is an etiologic factor in the development of type 2 diabetes mellitus (DM). Dr. Demmer proposes to study whether baseline exposure to known periodontal pathogens is associated with progression of DM risk factors over two years of longitudinal follow-up. Dr. Demmer and colleagues will assess the two year progression of fasting glucose, insulin resistance and beta-cell dysfunction and compare these progression rates between participants with high vs. low colonization levels of selected periodontal pathogens. This will be achieved using a longitudinal cohort design among n=300 participants in a population of tri-ethnic men and women aged 30 - 55 years at baseline enrollment. The proposed design will carefully control for potential confounders such as baseline levels of fasting glucose, insulin, lipids, obesity, diet, age, smoking, ethnicity and gender. The proposed research can advance the scientific knowledge regarding the well-known association between periodontal infection and type 2 diabetes mellitus through its provision of a powerful study design appropriate for addressing temporality (i.e., do periodontal infections precede the onset of diabetes pathology). In addition, data on the independent contribution of infections to the underlying pathology of diabetes can be addressed for the first time using a population based, chronic infection model. The independent phase research project will significantly enhance the applicant's qualifications to serve as principal investigator on a future R-01 application - an explicit aim of this funding mechanism.

描述（由申请人提供）：该职业发展建议旨在为Demmer博士提供必要的受保护的研究时间和培训，以从其博士后研究职位过渡到独立的终身教师职位。该提案由两个阶段组成：1）一个受过指导的阶段，重点是加强候选人的出版记录，并在候选人当前专业知识以外的研究领域获得其他培训； 2）在采购研究轨道教师职位后，将进行全面的研究项目。拟议的培训将在哥伦比亚大学医学中心的邮报公共卫生学院进行。具体而言，指导的博士后阶段将在以下四个模块中为高级训练提供机会​​：模块1）高级测量方法，重点是量化感染作为慢性疾病的病因学暴露的方法学方法；模块2）2型糖尿病流行病学和病理生理学；模块3）基因组学，重点是生物信息学和基因表达研究；模块4）传播科学发现和授予写作。独立阶段研究旨在检验牙周感染是2型糖尿病（DM）发展的病因学因素。 Demmer博士建议研究在两年的纵向随访中基线暴露于已知的牙周病原体是否与DM风险因素的进展有关。 Demmer博士及其同事将评估禁食葡萄糖，胰岛素抵抗和β细胞功能障碍的两年进展，并比较具有较高的牙周病原体的较高与低定殖水平的参与者之间的这些进展率。在基线入学时，n = 300名男女的n = 300名男性和女性人口中的n = 300名参与者中，这将实现这一目标。拟议的设计将仔细控制潜在的混杂因素，例如禁食葡萄糖，胰岛素，脂质，肥胖，饮食，年龄，吸烟，种族和性别的基线水平。拟议的研究可以通过提供适合解决时间性的强大研究设计（即，在糖尿病病理学的发作之前进行牙周感染设计），可以提高有关牙周感染与2型糖尿病之间众所周知的关联的科学知识。此外，可以首次使用基于人群的慢性感染模型来解决有关感染对糖尿病潜在病理的独立贡献的数据。独立阶段研究项目将显着提高申请人的资格，以作为未来R -01申请的首席研究员 - 这种融资机制的明确目的。

项目成果

Venous congestion and endothelial cell activation in acute decompensated heart failure.

• DOI: 10.1007/s11897-010-0009-5
• 发表时间: 2010-06-01
• 期刊: Current heart failure reports
• 作者: Ganda, Anjali;Onat, Duygu;Colombo, Paolo C
• 通讯作者: Colombo, Paolo C

Venous congestion, endothelial and neurohormonal activation in acute decompensated heart failure: cause or effect?

• DOI: 10.1007/s11897-015-0254-8
• 发表时间: 2015-06
• 期刊: CURRENT HEART FAILURE REPORTS
• 作者: Colombo, Paolo C;Doran, Amanda C;Onat, Duygu;Wong, Ka Yuk;Ahmad, Myra;Sabbah, Hani N;Demmer, Ryan T
• 通讯作者: Demmer, Ryan T