Periodontal Infections and Type 2 Diabetes Mellitus Risk

牙周感染和 2 型糖尿病风险

• 批准号: 8902549
• 负责人: Ryan T. Demmer
• 金额: $ 6.93万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8902549
• 关键词: Address; Age; Antibodies; Bacteria; Beta Cell; Blood Cells; Body Composition; Cardiovascular Diseases; Cell physiology; Cells; Chronic; Clinical; Data; Development; Diabetes Mellitus; Diet; Disease; Disease Outcome; Enrollment; Ethnic Origin; Exposure to; Functional disorder; Future; Gender; Gene Expression; Glycosylated hemoglobin A; Health; Homeostasis; Impaired fasting glycaemia; Incidence; Infection; Infectious Agent; Inflammation; Inflammatory Response; Insulin; Insulin Resistance; Knowledge; Link; Lipids; Measures; Mediating; Mediator of activation protein; Methods; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Participant; Pathology; Periodontal Diseases; Periodontal Infection; Physical activity; Population; Pregnancy Outcome; Process; Public Health; Reporting; Research; Research Design; Research Proposals; Risk; Risk Factors; Role; Scientific Advances and Accomplishments; Smoking; Source; Systemic disease; Testing; Woman; Working Women; aged; case control; cohort; design; diabetes risk; fasting glucose; fasting plasma glucose; follow-up; interest; men; pathogen; population based; time use; working men

Type 2 diabetes mellitus (diabetes) is a growing public health problem. Chronic infections have been suggested as a potential risk factor for diabetes and there is a known association between periodontal infections and diabetes. Although it is generally believed that periodontal infections are a consequence of existing diabetes, there is growing support for the hypothesis that periodontal infections might contribute tq diabetogenesis, although research on this topic is limited. The evidence supporting the role of periodontal infections as a risk factor for a number of other systemic diseases (i.e., cardiovascular disease and pregnancy outcomes) continues to grow and further supports the rationale for. the current research proposal. Furthermore, recent reports implicate inflammation as a strong risk factor for incident diabetes. Since the inflammatory response is a central aspect of periodontal pathology, it is of interest to explore whether or not inflammation might mediate the association between periodontal disease and diabetes, or simply be an underlying contributor to both disease processes. The current proposal aims to test the hypothesis that periodontal infection is an etiologic factor in the development of diabetes. Baseline exposure to known periodontal pathogens will be assessed to see if elevated infectious exposure is associated with accelerated progression of fasting glucose and insulin levels. This will be achieved using a longitudinal cohort design among n=300 participants in a population of men and women aged 25 - 55 years at baseline enrollment. The proposed design will carefully control for potential confounders such as baseline levels of fasting glucose, insulin, lipids, obesity, diet, age, smoking, ethnicity and gender.

2 型糖尿病（糖尿病）是一个日益严重的公共卫生问题。慢性感染被认为是糖尿病的潜在危险因素，并且已知牙周感染与糖尿病之间存在关联。尽管人们普遍认为牙周感染是现有糖尿病的结果，但越来越多的人支持牙周感染可能促进糖尿病发生的假设，尽管对此主题的研究有限。支持牙周感染作为许多其他全身性疾病（即心血管疾病和妊娠结局）危险因素的证据不断增加，并进一步支持其基本原理。目前的研究计划。此外，最近的报告表明炎症是糖尿病发生的一个重要危险因素。由于炎症反应是牙周病理学的一个核心方面，因此有必要探讨炎症是否可能介导牙周病和糖尿病之间的关联，或者仅仅是导致这两种疾病过程的潜在因素。目前的提议旨在检验牙周感染是糖尿病发展的一个病因因素的假设。将评估已知牙周病原体的基线暴露，以确定感染性暴露升高是否与空腹血糖和胰岛素水平的加速进展相关。这将通过在基线登记时年龄为 25 - 55 岁的男性和女性群体中 n=300 名参与者中的纵向队列设计来实现。拟议的设计将仔细控制潜在的混杂因素，例如空腹血糖、胰岛素、血脂、肥胖、饮食、年龄、吸烟、种族和性别的基线水平。