ShEEP Request for ACQUITY UPLC H-Class PLUS Bio System

ShEEP 请求 ACQUITY UPLC H-Class PLUS 生物系统

• 批准号: 9905799
• 负责人: SUSHIL K MAHATA
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9905799
• 关键词: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Affect; Anesthesiology; Animals; Antineoplastic Agents; Award; Behavioral Research; Cardiology; Caregivers; Catecholamines; Cells; Chemicals; Communities; Complex; Computer software; Data; Degenerative polyarthritis; Detection; Diabetes Mellitus; Disease; Dopamine; Drug Addiction; Electronics; Endocrinology; Epinephrine; Fluorescence; Funding; Glucose; Glucose-6-Phosphate; Healthcare; Healthcare Systems; Heating; Hypertension; Injury; Insulin Resistance; Investigation; Length; Libraries; Lighting; Malignant Neoplasms; Measures; Mental Health; Mission; Monitor; Mus; Nephrology; Neurology; Neurotransmitters; Noise; Norepinephrine; Nucleotides; Obesity; Operative Surgical Procedures; Optics; Patients; Plasma; Polysaccharides; Pre-Clinical Model; Rattus; Research; Research Personnel; Resolution; Sampling; Serotonin; Sheep; Solvents; Sugar Phosphates; System; Temperature; Time; Tissues; Urology; Veterans; addiction; clinical care; data management; design; detector; glucose 1 phosphate; innovation; instrument; light emission; method development; optical emission; pre-clinical; pre-clinical research; response; solute; sugar nucleotide; systems research

Project Summary The capability to measure catecholamines (norepinephrine and epinephrine), neurotransmitters (dopamine and serotonin), nucleotides [adenosine monophosphate (AMP), adenosine diphosphate (ADP), and adenosine triphosphate (ATP)], sugar nucleotides (UDP glucose), sugar phosphates [glucose 1 phosphate (G1P) and glucose 6 phosphate (G6P), glycans and glycan derivatives] in small tissue or plasma samples will significantly and positively impact a large number of VA-sponsored projects in basic, translational and preclinical biomedical/behavioral research relevant to Veteran’s healthcare currently conducted at the VA San Diego Healthcare System (VASDHS). Catecholamines, neurotransmitters, nucleotides, sugar phosphates, glycans and glycan derivatives are affected several disease states including hypertension, diabetes, obesity, cancer, osteoarthritis, addiction and traumatic disorders. We are a group of 11 currently funded investigators with VA Merit Awards who will directly benefit from acquisition of the ACQUITY UPLC H-Class PLUS Bio system with Photodiode Array (PDA) and Fluorescence detectors. Our projects encompass a wide range of fields and research, including nephrology/hypertension, endocrinology, neurology, anesthesiology, cardiology, urology, and surgery. The acquisition of the ACQUITY UPLC H-Class PLUS Bio system with Photodiode Array (PDA) and Fluorescence detectors will not only impact basic pre-clinical research at VASDHS, but also is expected to have a strong and positive effect through improvement of patient clinical care and supporting the VA healthcare mission.

项目概要 能够测量儿茶酚胺（去甲肾上腺素和肾上腺素）、神经递质 （多巴胺和血清素）、核苷酸 [单磷酸腺苷 (AMP)、二磷酸腺苷 (ADP)、三磷酸腺苷(ATP)]、糖核苷酸(UDP葡萄糖)、糖磷酸酯 [葡萄糖 1 磷酸盐 (G1P) 和葡萄糖 6 磷酸盐 (G6P)、聚糖和聚糖衍生物] 小 组织或血浆样本将对大量 VA 资助的项目产生显着和积极的影响 与退伍军人相关的基础、转化和临床前生物医学/行为研究项目 目前在 VA 圣地亚哥医疗系统 (VASDHS) 进行医疗保健。 神经递质、核苷酸、磷酸糖、聚糖和聚糖衍生物受到多种影响 疾病状态包括高血压、糖尿病、肥胖、癌症、骨关节炎、成瘾和 我们是由 11 名目前获得 VA 优异奖资助的研究人员组成的小组。 将直接受益于收购带有光电二极管的 ACQUITY UPLC H-Class PLUS Bio 系统 我们的项目涵盖广泛的领域和领域。 研究，包括肾病学/高血压、内分泌学、神经病学、麻醉学、心脏病学、 收购 ACQUITY UPLC H-Class PLUS Bio 系统 光电二极管阵列 (PDA) 和荧光探测器不仅会影响基础的临床前研究 在 VASDHS 中，也有望通过改善患者的病情产生强大而积极的效果 临床护理和支持 VA 医疗保健使命。