HIV Testing and Women's Attitudes on HIV Vaccine Trials

HIV 检测和女性对 HIV 疫苗试验的态度

• 批准号: 7342100
• 负责人: GREGORY D. ZIMET
• 金额: $ 51.41万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7342100
• 关键词: AIDS/HIV problem; Address; Advocate; African American; Attitude; Behavior; Behavioral; Belief; Clinic; Clinical Trials; Community Health; Computer Assisted; Condition; Data Analyses; Development; Drug usage; Educational Background; Enrollment; Equation; Equilibrium; Ethnic Origin; Focus Groups; HIV; HIV Seropositivity; HIV vaccine; Human immunodeficiency virus test; Individual; Injection of therapeutic agent; Intervention; Intervention Studies; Interview; Latina; Lead; Link; Literature; Logistic Regressions; Measures; Mediating; Mediator of activation protein; Minority; Modeling; Not Hispanic or Latino; Outcome; Participant; Perception; Persuasive Communication; Phase; Phase III Clinical Trials; Planning Theory; Preventive; Process; Public Health; Race; Randomized; Rate; Recording of previous events; Recruitment Activity; Research; Research Personnel; Services; Side; Source; Structure; Surveys; Testing; Upper arm; Vaccination; Vaccine Clinical Trial; Vaccines; Woman; Women' s Group; design; health belief; improved; programs; response; theories; treatment trial; willingness

This 5-year proposal responds to PAS-03-168, "Enrolling Women and Minorities in HIV/AIDS Research Trials." This study seeks to evaluate persuasive message interventions to increase HIV testing rates and improve acceptability of participation in a phase 3 HIV vaccine clinical trial among African-American, Latina, and White women. We plan to evaluate 1-sided messages, which mention only the benefits of an action, versus 2-sided messages, which mention negative aspects of the action, followed by positive counter- arguments. The Health Belief Model, Inoculation and Attribution Theories will guide the research. Participants will be women attending urban community health clnics in Indianapolis, IN. Specific Aim 1 is to identify obstacles to HIV testing and to participation in a HIV vaccine clinical trial. This aim will be accomplished in years 1 and 2 through 45 individual semi-structured interviews and 6 focus group interviews. We will analyze data via thematic content analysis and will use interview findings to assist in the development of measures and interventions employed in the intervention phase (years 3-5). Specific Aim 2 is to evaluate the effects of 2-sided versus 1-sided persuasive messages on rates of acceptance of rapid HIV testing. Demographic, behavioral, and attitudinal measures will be administered via audio computer-assisted self-interview (A-CASI). Participants will be randomized to the intervention groups via A-CASI as well. The outcome will be acceptance/rejection of free rapid HIV testing. Specific Aim 3 is to evaluate the effects of 2- sided versus 1-sided messages on willingness to participate in phase 3 clinical trials for a preventive HIV vaccine. Participants will complete this 2nd A-CASI survey and will again be randomized to intervention groups. The outcome will be a scale measuring acceptability of clinical trial participation. The order of presentation of the 2 A-CASI surveys and interventions will be counter-balanced such that half of the participants are randomly selected to receive the HIV testing component first and half are randomly selected to receive the HIV vaccine trial component first. We will analyze data via multiple linear and logistic regression modeling and with structural equation modeling. This study is relevant to public health in that the results may help us to understand how to improve enrollment of women and minorities into preventive HIV vaccine clinical trials and how to encourage women and minorities to get tested for HIV.

这项为期5年的提案对PAS-03-168做出了回应，“招募妇女和少数民族参加艾滋病毒/艾滋病研究 试验。 提高参与第三阶段HIV疫苗临床试验的可接受性 和白人妇女。我们计划评估1个方面的消息，仅提及动作的好处， 相对于两面消息，其中提到了动作的负面方面，然后是积极的反对 争论。健康信念模型，接种和归因理论将指导研究。 参与者将是在印第安纳州印第安纳波利斯参加城市社区健康群体的妇女。具体目标1是 确定HIV检测的障碍并参与HIV疫苗临床试验。这个目标将是 在第1和2至45年的半结构访谈和6个焦点小组中完成 访谈。我们将通过主题内容分析分析数据，并将使用访谈结果来协助 在干预阶段采用的措施和干预措施（3-5年）。具体目标2 是评估两面与1个有说服力的信息对快速HIV接受率的影响 测试。人口，行为和态度措施将通过计算机辅助管理 自我面试（A-Casi）。参与者也将通过A-CASI随机分为干预组。这 结果将是接受/拒绝自由快速HIV测试。特定目的3是评估2-的影响 侧面与1个方面的消息，愿意参加预防艾滋病毒的第三阶段临床试验 疫苗。参与者将完成这项第二次A-CASI调查，并将再次进行干预 组。结果将是测量临床试验参与的可接受性的量表。顺序 2个A-CASI调查和干预措施的介绍将是平衡的，以使一半 随机选择参与者以随机选择HIV测试组件，然后随机选择 首先接收HIV疫苗试验组件。我们将通过多个线性和逻辑分析数据 回归建模和结构方程建模。这项研究与公共卫生有关 结果可能有助于我们了解如何改善妇女和少数民族的入学率 疫苗临床试验以及如何鼓励妇女和少数族裔接受艾滋病毒的测试。