HIV Testing and Women's Attitudes on HIV Vaccine Trials

HIV 检测和女性对 HIV 疫苗试验的态度

• 批准号: 7208069
• 负责人: GREGORY D. ZIMET
• 金额: $ 44.78万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7208069
• 关键词: AIDS/HIV problem; Address; Advocate; African American; Attitude; Behavior; Behavioral; Belief; Clinic; Clinical Trials; Community Health; Computer Assisted; Condition; Data Analyses; Development; Drug usage; Educational Background; Enrollment; Equation; Equilibrium; Ethnic Origin; Focus Groups; HIV; HIV Seropositivity; HIV vaccine; Human immunodeficiency virus test; Individual; Injection of therapeutic agent; Intervention; Intervention Studies; Interview; Latina; Lead; Link; Literature; Logistic Regressions; Measures; Mediating; Mediator of activation protein; Minority; Modeling; Not Hispanic or Latino; Outcome; Participant; Perception; Persuasive Communication; Phase; Phase III Clinical Trials; Planning Theory; Preventive; Process; Public Health; Race; Randomized; Rate; Recording of previous events; Recruitment Activity; Research; Research Personnel; Services; Side; Source; Structure; Surveys; Testing; Upper arm; Vaccination; Vaccine Clinical Trial; Vaccines; Woman; Women' s Group; design; health belief; improved; programs; response; theories; treatment trial; willingness

DESCRIPTION (provided by applicant): This 5-year proposal responds to PAS-03-168, "Enrolling Women and Minorities in HIV/AIDS Research Trials." This study seeks to evaluate persuasive message interventions to increase HIV testing rates and improve acceptability of participation in a phase 3 HIV vaccine clinical trial among African-American, Latina, and White women. We plan to evaluate 1-sided messages, which mention only the benefits of an action, versus 2-sided messages, which mention negative aspects of the action, followed by positive counter- arguments. The Health Belief Model, Inoculation and Attribution Theories will guide the research. Participants will be women attending urban community health clinics in Indianapolis, IN. Specific Aim 1 is to identify obstacles to HIV testing and to participation in a HIV vaccine clinical trial. This aim will be accomplished in years 1 and 2 through 45 individual semi-structured interviews and 6 focus group interviews. We will analyze data via thematic content analysis and will use interview findings to assist in the development of measures and interventions employed in the intervention phase (years 3-5). Specific Aim 2 is to evaluate the effects of 2-sided versus 1-sided persuasive messages on rates of acceptance of rapid HIV testing. Demographic, behavioral, and attitudinal measures will be administered via audio computer-assisted self-interview (A-CASI). Participants will be randomized to the intervention groups via A-CASI as well. The outcome will be acceptance/rejection of free rapid HIV testing. Specific Aim 3 is to evaluate the effects of 2- sided versus 1-sided messages on willingness to participate in phase 3 clinical trials for a preventive HIV vaccine. Participants will complete this 2nd A-CASI survey and will again be randomized to intervention groups. The outcome will be a scale measuring acceptability of clinical trial participation. The order of presentation of the 2 A-CASI surveys and interventions will be counter-balanced such that half of the participants are randomly selected to receive the HIV testing component first and half are randomly selected to receive the HIV vaccine trial component first. We will analyze data via multiple linear and logistic regression modeling and with structural equation modeling. This study is relevant to public health in that the results may help us to understand how to improve enrollment of women and minorities into preventive HIV vaccine clinical trials and how to encourage women and minorities to get tested for HIV.

描述（由申请人提供）：这项为期5年的提案对PAS-03-168做出了回应，“招募妇女和少数民族参加艾滋病毒/艾滋病研究试验”。这项研究旨在评估有说服力的消息干预措施，以提高HIV测试率，并提高参与3期HIV HIV疫苗临床试验中非裔美国人，拉丁裔和白人妇女的可接受性。我们计划评估1个方面的消息，这些消息仅提及动作的好处，与2面消息相比，其中提到了动作的负面方面，然后是积极的反参数。健康信念模型，接种和归因理论将指导研究。参与者将是在印第安纳州印第安纳波利斯的城市社区卫生诊所参加的妇女。具体目的1是确定HIV检测的障碍并参与HIV疫苗临床试验。这个目标将在第1至2至45年的独立半结构化访谈和6次焦点小组访谈中实现。我们将通过主题内容分析分析数据，并将使用访谈结果来协助开发干预阶段采用的措施和干预措施（3-5年）。具体目的2是评估两面与1个有说服力的信息对快速HIV测试率的影响。人口统计，行为和态度措施将通过音频计算机辅助的自我浏览（A-CASI）来管理。参与者也将通过A-CASI随机分为干预组。结果将是接受/拒绝自由快速HIV测试。具体目的3是评估2面与1面信息对预防HIV疫苗3阶段临床试验意愿的影响。参与者将完成这项第二次A-CASI调查，并将再次随机分为干预组。结果将是测量临床试验参与的可接受性的量表。两次A-CASI调查的介绍顺序和干预措施将是平衡的，因此，随机选择了一半的参与者以首先选择接受HIV测试组件，以首先接收HIV疫苗试验组件。我们将通过多个线性和逻辑回归建模以及结构方程建模来分析数据。这项研究与公共卫生有关，因为结果可能有助于我们了解如何改善妇女和少数群体进入预防性HIV疫苗临床试验的入学率，以及如何鼓励妇女和少数族裔接受HIV测试。