Scalable Electrode Technology for High Resolution Chronic Recording of Brain

用于大脑高分辨率慢性记录的可扩展电极技术

基本信息

批准号：
9769173
负责人：
Stuart F Cogan
金额：
$ 63.48万
依托单位：
UNIVERSITY OF TEXAS DALLAS
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9769173
关键词：
Address Amputation Animal Experimentation Animal Model Animals Architecture Area Behavior Biomechanics Brain Caliber Chronic Collaborations Communities Deposition Development Devices Dimensions Electrodes Electrophysiology (science)Encapsulated Failure Film Foreign Bodies Functional disorder Histology Human Imagery Implant Implanted Electrodes Individual Industry Standard Laboratories Learning Measurement Methods Microelectrodes Microfabrication Modeling Motor Motor Cortex Neurologic Deficit Neuronal Dysfunction Neurons Neurophysiology - biologic function Neurosciences Neurosciences Research Pattern Penetration Performance Process Rattus Reproducibility Research Personnel Resistance Resolution Rodent Signal Transduction Silicon Site Spinal cord injury Stroke Study models Techniques Technology Testing Texas Thinness Tissues Universities Work base brain computer interface carbon fiber clinical application cost density design experience extracellular flexibility histological studies implantable device implantation insight instrumentation manufacturing process mechanical properties motor control nervous system disorder neural circuit neural network neural prosthesis neural stimulation neuronal circuitry neuroregulation neurotransmission nonhuman primate novel programs relating to nervous system response sensory cortex silicon carbide somatosensory tissue phantom tool

项目摘要

Abstract Chronically implanted microelectrode arrays (MEAs) for recording extracellular neural activity are central to scientific studies of neural circuit function in behaving animals. These studies seek to understand how neurons encode information and how neural signals can be decoded to provide insights into brain learning and dysfunction. The majority of microelectrode MEAs, and especially those available commercially, are fabricated from silicon and leverage techniques associated with integrated circuit microfabrication and packaging. For microelectrode MEAs, the major limitations for chronic neural recording are the reactive tissue response that encapsulates electrodes and kills or damages neurons in the vicinity of the electrode and the degradation and failure of materials used in MEA fabrication. An effective means of minimizing the foreign body response is the use of ultramicroelectrode MEAs (UMEAs) with subcellular cross-sectional dimensions. In related work, we have demonstrated that carbon-fiber ultramicroelectrodes substantially evade a foreign body response and have been shown to provide stable chronic neural recordings in small-animal models. However, a scalable manufacturing process for carbon-fiber ultramicroelectrodes has not emerged. The proposed effort is aimed at developing and demonstrating the chronic stability and reliability of ultramicroelectrodes based on amorphous silicon carbide (a- SiC) UMEAs that are fabricated by industry-standard thin-film processes. We aim to develop a fabrication process for a-SiC UMEAs with 32 to 128 ultramicroelectrodes and demonstrate the stability of these UMEAs through accelerated laboratory testing and their functionality by neural recording and histology using chronic implants in rat cortex and in a 3-4 year non-human primate study. To facilitate dissemination of the a-SiC UMEA technology, electrical interconnect hardware and implantation methods will also be developed. We anticipate the proposed a-SiC UMEAs impacting the neuroscience community by providing a highly stable neural interface that allows single-unit and ensemble recording for probing neuronal circuitry on a dimensional scale that is not possible with current multielectrode recording devices. We expect a-SiC UMEAs will provide new insights into the neural networks and changes in neural circuitry that may accompany behavior and adaption.

抽象的用于记录细胞外神经活动的长期植入微电极阵列（MEA）是对行为动物神经回路功能的科学研究。这些研究旨在了解神经元如何编码信息以及如何解码神经信号以提供对大脑学习和理解的见解功能障碍。大多数微电极 MEA，尤其是市售的微电极 MEA，都是制造的来自硅并利用与集成电路微制造和封装相关的技术。为了微电极 MEA，慢性神经记录的主要限制是反应性组织反应封装电极并杀死或损害电极附近的神经元以及降解和 MEA 制造中使用的材料失效。减少异物反应的有效方法是使用具有亚细胞横截面尺寸的超微电极 MEA (UMEA)。在相关工作中，我们有证明碳纤维超微电极基本上可以避免异物反应，并且已被显示可在小动物模型中提供稳定的慢性神经记录。然而，可扩展的制造碳纤维超微电极的工艺尚未出现。拟议的努力旨在开发和展示了基于非晶碳化硅（a- SiC) UMEA 采用行业标准薄膜工艺制造。我们的目标是开发一种制造具有 32 至 128 个超微电极的 a-SiC UMEA 工艺，并展示了这些 UMEA 的稳定性通过加速实验室测试及其功能通过神经记录和组织学使用慢性植入大鼠皮层和一项为期 3-4 年的非人类灵长类动物研究。促进 a-SiC UMEA 的传播技术、电气互连硬件和植入方法也将得到开发。我们预计提出的 a-SiC UMEA 通过提供高度稳定的神经接口来影响神经科学界允许单个单元和整体记录，以在非维度尺度上探测神经元电路目前的多电极记录设备是可能的。我们预计 a-SiC UMEA 将提供新的见解可能伴随行为和适应的神经网络和神经回路的变化。