IMAGING CORE

成像核心

基本信息

批准号：
7596939
负责人：
MICHAEL W WEINER
金额：
$ 18.05万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7596939
关键词：
3-Dimensional Age Alzheimer&apos s Disease Arts Atlases Award Blood flow Brain Brain region Cerebrospinal Fluid Characteristics Choline Clinical Computer software Creatine Data Data Analyses Dementia Department of Defense Diagnosis Diffusion Early Diagnosis Elderly Excitatory Amino Acids Exhibits Frontotemporal Dementia Funding Future Gender Glutamates Goals Housing Image Impaired cognition Inositol Investigation Knowledge Label Left Lesion Lewy Body Disease Lobar Lobe Longitudinal Studies Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Manuals Measures Medical center Metabolic N-acetylaspartate Nerve Degeneration Neurodegenerative Disorders Neurons Numbers Patients Pattern Perfusion Recruitment Activity Research Design Scanning Side Spin Labels Staging Structure System Techniques Tissues United States National Institutes of Health Vascular Dementia Vascular Diseases Weight Work arterial lesion gray matter member normal aging novel strategies software development white matter

项目摘要

The overall long term goal of this Imaging Core is to identify structural, perfusion, and metabolic changes in the brain that predict future cognitive decline and conversion to dementia. The overall approach will be to initially study healthy elders ands age/gender matched patients with well-characterized dementia associated with Alzheimer's disease and Frontotemporal dementia using a newly acquired 4 Tesla BrukedSiemens MRI/MRS scanner, which will be optimized for investigation of neurodegenerative disease. These initial studies will provide imaging characteristics of established dementia. We will also study a group of subjects with MCI-Peterson criteria. In subsequent years we will study increasing numbers of subjects with MCI subtypes and MCI-Peterson who likely represent early stages of AD and FTD and who are expected to ultimately convert to dementia. All subjects will be recruited and evaluated by the Clinical Core.

这种成像核心的总体长期目标是确定大脑中的结构，灌注和代谢变化，以预测未来的认知能力下降和转化为痴呆症。总体方法是使用新获得的4个Tesla brukedsiemens MRI/MRS Scanner匹配与阿尔茨海默氏病和额颞痴呆相关的健康长老和性别相匹配的患者，该患者将优化为神经脱发性疾病的研究。这些最初的研究将提供既定痴呆症的成像特征。我们还将研究一组具有MCI-Peterson标准的受试者。在随后的几年中，我们将研究MCI亚型和MCI-Peterson的受试者数量的越来越多，他们可能代表AD和FTD的早期阶段，并有望最终转化为痴呆症。所有受试者将由临床核心招募和评估。