The Mobile Toolbox for Monitoring Cognitive Function - Project

用于监测认知功能的移动工具箱 - 项目

• 批准号: 10212850
• 负责人: MICHAEL W WEINER
• 金额: $ 93.72万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10212850
• 关键词: Adult; Age; Alzheimer' s Disease; Android; Assessment tool; Brain Health Registry; Calibration; Cellular Phone; Clinical; Cognition; Cognitive; Computer software; Computers; Consent; Custom; Data; Data Analyses; Data Collection; Diagnostic; Disease; Emotions; Ethnic Origin; General Population; Geography; Goals; Gold; Health; Health Status; Impaired cognition; Intelligence; Internet; Libraries; Longevity; Measures; Methodology; Methods; Monitor; Moods; Neuropsychological Tests; Parkinson Disease; Participant; Patient Self-Report; Personality; Procedures; Property; Protocols documentation; Psychometrics; Public Domains; Questionnaires; Race; Registries; Research; Research Personnel; Research Project Grants; Resources; Respondent; Risk; Sampling; Self Administration; Series; Testing; United States National Institutes of Health; Validation; Withdrawal; base; biological sex; cognitive ability; cognitive change; cognitive function; cognitive task; cognitive testing; data management; demographics; design; flexibility; follow up assessment; follow-up; healthy aging; innovation; instrument; mobile application; programs; public repository; response; theories; validation studies

Project Summary Our research project will be a collaborative effort supported by all of the MobileToolbox Cores. The project will function as the vehicle within which we develop and psychometrically evaluate our cognitive assessment tools. We will do this by accomplishing the following specific aims. Aim 1: We will develop a repository of public-domain cognitive ability measures that enhance the assessment of cognitive change across the lifespan by enabling self-administered testing via iOS and Android smartphones. The MobileToolbox measures will be designed around the technical specifications of a flexible and open software platform that enables external researchers to customize use of the mobile app to fit the needs of their studies. Researchers will be able to choose from a diverse selection of cognitive measures, including several cognitive tasks highly sensitive to change, along with measures of contextual variables of relevance to cognitive functioning (e.g., mood, personality, health status). Aim 2: Evaluate the psychometric properties of MobileToolbox instruments through implemention of a series of data collection protocols aimed at calibration, norming, and face-to-face validation against existing gold standards. We will calibrate Item Response Theory based measures by administering them to a large (N=4,800) general population calibration sample. All newly developed MobileToolbox measures will be validated against existing gold standards in a sample of healthy adults ages 20-85. The validation protocol will include face-to-face administration of the NIH Toolbox Cognition Battery, core sub-tests of the Wechsler Adult Intelligence Scale (WAIS-IV), and additional tests as needed. During this cross-sectional validation session, respondents (N=260) will complete the self-administered MobileToolbox via smartphone in an un-proctored setting. Additional validation will be undertaken in existing clinical (e.g., cognitively impaired, Parkinson’s disease) and general population (e.g. Healthy Aging Study, N=100,000) samples. Finally, we will identify normative values for the MobileToolbox measures using a large, nationally-representative sample (N=6,800). Sub-samples of respondents will be used to identify normative cognitive change by completing 3-, 12- and 24- month follow-up assessments.

项目摘要 我们的研究项目将是所有MobileToolBox Cores支持的协作努力。该项目将 充当我们开发和心理评估认知评估工具的工具。 我们将完成以下特定目标来做到这一点。 目标1：我们将开发一个公共域认知能力指标的存储库，以增强 通过iOS和 Android智能手机。 MobileToolBox措施将围绕一个技术规格而设计 灵活和开放的软件平台，使外部研究人员能够自定义移动应用程序使用 他们的学习需求。研究人员将能够从潜水员选择的认知测量值中进行选择， 包括几个对变化高度敏感的认知任务，以及测量的上下文变量 与认知功能有关（例如情绪，个性，健康状况）。 目标2：通过实施A MobileToolBox仪器的心理测量特性 一系列旨在校准，规范和面对面验证的数据收集协议 现有的黄金标准。我们将通过将其管理为基于项目响应理论的措施来校准。 大型（n = 4,800）一般人口校准样本。所有新开发的MobileToolBox措施将是 在20-85岁的健康成年人样本中，根据现有的黄金标准进行了验证。验证协议将 包括NIH工具箱认知电池的面对面管理，Wechsler成人的核心子测试 智能量表（WAIS-IV）和其他测试。在此横断面验证会话中， 受访者（n = 260）将通过未销售的智能手机完成自我管理的MobileToolbox 环境。将在现有临床中进行其他验证（例如，认知受损，帕金森氏症 疾病）和普通人群（例如健康的衰老研究，n = 100,000）样本。最后，我们将确定 MobileToolbox的正常值使用大型，代表性的样本（n = 6,800）进行。 受访者的子样本将用于通过完成3，12-和24-来确定正常的认知变化 月随访评估。