2020 Plasminogen Activation and Extracellular Proteolysis Gordon Research Conference and Gordon Research Seminar

2020年纤溶酶原激活与细胞外蛋白水解戈登研究会议暨戈登研究研讨会

基本信息

批准号：
9896285
负责人：
Styliani-Anna (Stella) E Tsirka
金额：
$ 1.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-01 至 2020-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9896285
关键词：
Achievement Aging Alteplase Area Basic Science Biology Blood Blood Coagulation Disorders Blood Vessels Brain hemorrhage Cardiovascular Physiology Cardiovascular system Cell physiology Cerebral Ischemia Cerebrovascular Disorders Clinic Clinical Research Collaborations Communicable Diseases Communities Data Deep Vein Thrombosis Dementia Deposition Development Diagnosis Disease Educational process of instructing Ensure Environment Event Fibrin Fostering Functional disorder Funding Generations Goals Growth Health Hematopoiesis Homeostasis Human Inflammatory International Ischemic Stroke Knowledge Lead Location Malignant Neoplasms Metabolism Musculoskeletal Diseases Myocardial Infarction Natural regeneration Nervous System Physiology Neuraxis Neurodegenerative Disorders Obesity Organ Participant Pathologic Processes Pathway interactions Peptide Hydrolases Physicians Physiological Processes Physiology Plasmin Plasminogen Plasminogen Activator Postdoctoral Fellow Pregnancy Prevention Process Proteins Proteolysis Recombinants Research Research Personnel Role Scientist System Therapeutic Thrombin Tissues Translating Trauma Tumor Biology Underrepresented Groups Woman Work angiogenesis career cerebrovascular clinically relevant expectation experience extracellular frontier graduate student improved meetings mid-career faculty nervous system disorder neuropsychiatric disorder new technology peer peer networks pre-doctoral stem cell biology symposium

项目摘要

Summary Partial support is requested for graduate students and post-doctoral fellows, and junior and midcareer faculty to participate in the Gordon Research Seminar and Conference (GRS/GRC) entitled “Plasminogen Activation and Extracellular proteolysis”, which will be held in Ventura, CA on February 8-9 and 9-14, 2020. This will be the 16th GRC, as the conference has been held continuously every two years since 1990. The focus of the 2020 GRC will be on mechanisms and functions of extracellular proteolytic enzymes, such as fibrin(ogen), thrombin, plasmin(ogen), plasminogen activators, their precursors and effectors. Recent data suggest that the expression of these blood proteases may be related to diseases associated with normal and pathological processes. Our invited speakers and discussion leaders will present their recent and emerging work, and emphasis will be placed on the roles of these proteins in pathophysiological events including deteriorating cerebrovascular function with aging, coagulopathies and cerebral ischemia, musculoskeletal and neurodegenerative diseases associated with depositions of fibrin, development of cancer, inflammatory diseases, and the technological advances in targeting them for the generation of new treatments. One of the major goals for the 2020 GRC meeting is translating basic research into the clinic. Attendees will be selected by invitation and from applications submitted online. They will be chosen to represent a diverse spectrum of research, and a strong emphasis will be made on the inclusion of women and scientists from underrepresented groups. An intended strength of this meeting will be the interaction and networking of the young scientists in the field, with the discussion leaders and the speakers. The associated GRS, which is a much younger feature of the conference, will provide a unique opportunity for trainees and scientists to share in the GRC experience. This two-day seminar will be organized by Graduate Students and Postdoctoral Fellows with the support of leading researchers and the GRC Chairs, and will allow junior researchers within the field of plasminogen activation and extracellular proteolysis to come together to discuss their current research, while building informal networks with their peers that may lead to a lifetime of collaboration and scientific achievement.

概括要求为研究生和博士后研究员以及初级和中期教师提供部分支持参加戈登研究研讨会和会议（GRS/GRC），题为“纤溶酶原激活” 和细胞外蛋白水解”，将于 2020 年 2 月 8-9 日和 9-14 日在加利福尼亚州文图拉举行。第十六届GRC自1990年起每两年连续举办一次。 2020 GRC将讨论细胞外蛋白水解酶的机制和功能，例如纤维蛋白（原）、凝血酶、纤溶酶（原）、纤溶酶原激活剂、它们的前体和效应物。这些血液蛋白酶的表达可能与正常和病理相关的疾病有关。我们邀请的演讲者和讨论领袖将介绍他们最近和新兴的工作，以及重点将放在这些蛋白质在病理生理事件中的作用，包括恶化脑血管功能与衰老、凝血病和脑缺血、肌肉骨骼和与纤维蛋白沉积、癌症发展、炎症相关的神经退行性疾病疾病，以及针对这些疾病产生新疗法的技术进步。 2020 年 GRC 会议的主要目标是将基础研究转化为临床。通过邀请和在线提交的申请，他们将被选为代表不同领域的人。研究，并将重点关注来自代表性不足的妇女和科学家的纳入这次会议的一个优势是年轻科学家的互动和交流。现场，讨论领袖和演讲者。会议将为学员和科学家提供一个分享 GRC 经验的独特机会。这次为期两天的研讨会将由研究生和博士后研究员在以下机构的支持下组织：领先的研究人员和 GRC 主席，并将允许纤溶酶原领域的初级研究人员激活和细胞外蛋白水解聚集在一起讨论他们当前的研究，同时建立与同行的非正式网络可能会带来终生的合作和科学成就。