Advanced MR Imaging of Early Osteoarthritis

早期骨关节炎的先进 MR 成像

基本信息

批准号：
9889034
负责人：
Garry E Gold
金额：
$ 18.18万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-04-01 至 2023-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9889034
关键词：
Affect Area Award Biomechanics Biomedical Engineering Bone Marrow Cartilage Cartilage Matrix Chemicals Clinical Collaborations Collection Degenerative polyarthritis Detection Development Diffusion Discipline Disease Disease Progression Doctor of Philosophy Electrical Engineering Engineering Free Will Functional disorder Funding Glycosaminoglycans Gold Human Human Resources Image Imaging Device Individual Knee Lead Learning Lesion Letters Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Mechanics Medical Students Meniscus structure of joint Mentors Methods Mid-Career Clinical Scientist Award (K24)Midcareer Investigator Award in Patient-Oriented Research Morphology Musculoskeletal Musculoskeletal Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institute of Biomedical Imaging and Bioengineering Noise Orthopedics Patients Phase Physicians Population Postdoctoral Fellow Process Protocols documentation Radiology Specialty Recording of previous events Relaxation Reproducibility Request for Applications Research Research Personnel Resources Rheumatology Scanning Scientist Signal Transduction Societies Sodium Students Synovitis Techniques Technology Testing Thinness Three-Dimensional Imaging Time Training United States National Institutes of Health Universities Wages Weight-Bearing state Work arthropathies career cohort design early detection biomarkers effusion graduate student imaging biomarker imaging modality improved joint loading macromolecule musculoskeletal imaging new technology novel novel strategies patient oriented research professor recruit temporal measurement therapy development undergraduate student

项目摘要

Project Summary / Abstract This is a renewal application for a Midcareer Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Garry Gold, is a physician-scientist, Professor of Radiology, Bioengineering, and Orthopedics at Stanford University. Over the past 15 years, Dr. Gold has developed expertise in several advanced musculoskeletal imaging and biomechanics techniques and applied these to the study of osteoarthritis and joint diseases. This has led to his developing an independent patient-oriented research (POR) career. He has received two independent research awards from the NIH that use MR techniques to investigate the pathophysiology of musculoskeletal diseases (both from NIBIB) and recently received an award from NIAMS to use Weight-Bearing CT to study joint loading. Dr. Gold has a 10-year history of mentoring junior clinician scientists, postdoctoral fellows, medical students, graduate students, and undergraduates - all performing POR. In addition, Dr. Gold has active collaborations with many NIH-funded investigators in the area of musculoskeletal research and imaging. The current application requests funding (50% salary) for 5 years. This funding will guarantee that the candidate will have at least 70% protected time to conduct his ongoing research and to continue to mentor clinician scientists performing POR. This award will free time now devoted to administrative and clinical responsibilities to focus more on his research and mentoring activities over the next 5 years. In addition to working on the ongoing NIH-funded projects, Dr. Gold will obtain additional training in advanced MR collection and analysis methods. This will allow the candidate to develop new approaches to apply to the imaging of musculoskeletal diseases. Given the outstanding resources and collaborations at Stanford, these novel projects are expected to be either renewed or to lead to new directions in orthopedic research, and significantly contribute to our scientific understanding of these disabling conditions.

项目概要/摘要这是一份以患者为导向的研究中职业生涯研究者奖 (K24) 的续签申请。申请人 Garry Gold 博士是一位医师科学家、放射学、生物工程和医学教授斯坦福大学骨科。在过去 15 年中，Gold 博士在多个领域积累了专业知识先进的肌肉骨骼成像和生物力学技术，并将其应用于研究骨关节炎和关节疾病。这导致他开发了一个独立的以患者为导向的研究（POR）职业。他获得了 NIH 颁发的两项使用 MR 的独立研究奖研究肌肉骨骼疾病病理生理学的技术（均来自 NIBIB）和最近获得了 NIAMS 的奖项，使用负重 CT 研究关节负荷。戈尔德博士有一个拥有 10 年指导初级临床科学家、博士后研究员、医学生、研究生和本科生 - 都在表演 POR。此外，戈尔德博士还积极与许多 NIH 资助的研究人员在肌肉骨骼研究领域合作成像。目前的申请要求资助（50%工资）5年。这笔资金将保证候选人将有至少 70% 的受保护时间来进行正在进行的研究并继续指导临床科学家进行 POR。该奖项现在将空闲时间专门用于行政和临床职责更多地关注他的研究和指导活动未来5年。除了致力于正在进行的 NIH 资助项目之外，Gold 博士还将获得高级 MR 采集和分析方法的额外培训。这将使候选人能够开发应用于肌肉骨骼疾病成像的新方法。鉴于杰出的斯坦福大学的资源和合作，这些新颖的项目预计将被更新或引领骨科研究的新方向，并为我们的科学做出重大贡献了解这些致残条件。