Development of Sodium Fluoride PET-MRI for Quantitative Assessment of Knee Osteoarthritis

氟化钠 PET-MRI 定量评估膝骨关节炎的发展

• 批准号: 10202485
• 负责人: Garry E Gold
• 金额: $ 42.56万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-16 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202485
• 关键词: 3-Dimensional; Affect; Anatomy; Architecture; Arthralgia; Bilateral; Biochemical; Biomechanics; Bone Matrix; Bone Spur; Bone Tissue; Bone remodeling; Canes; Cartilage; Clinical; Data; Degenerative polyarthritis; Deposition; Development; Diagnostic Imaging; Disease; Disease Progression; Dose; Environment; Extracellular Matrix; Fluoride Ion; Future; Gait; Health; Human; Hybrids; Image; Imaging Device; Imaging Techniques; Imaging technology; Intervention; Joints; Knee; Knee Osteoarthritis; Knee joint; Lateral; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Medial; Metabolic; Metabolism; Methodology; Methods; Modeling; Modification; Morphology; Multimodal Imaging; Needs Assessment; Orthopedics; Osteotomy; Pain; Pathogenesis; Patients; Performance; Perfusion; Photons; Physiology; Population; Positron-Emission Tomography; Process; Productivity; Protocols documentation; Quality of life; Reporting; Reproducibility; Research; Rest; Risk Factors; Roentgen Rays; Sclerosis; Severities; Shapes; Societies; Sodium Fluoride; Techniques; Technology; Testing; Three-Dimensional Imaging; Time; Tissues; Tracer; Treatment Efficacy; Work; analysis pipeline; attenuation; base; bone; bone metabolism; cartilage metabolism; clinical translation; cost; deep learning; disability; efficacy evaluation; flexibility; gait examination; gait rehabilitation; imaging approach; imaging capabilities; imaging modality; imaging system; improved; innovation; joint loading; kinetic model; mechanical force; mechanical properties; mineralization; molecular marker; non-invasive imaging; novel; novel imaging technique; pharmacokinetic model; quantitative imaging; radiotracer; response; soft tissue; subchondral bone; tool; treatment strategy; uptake

Project Summary Osteoarthritis (OA) is the leading cause of disability worldwide. The inability of non-invasive techniques to quantify disease progression has limited understanding of the pathogenesis of OA. While numerous magnetic resonance imaging (MRI) methods have been proposed for imaging OA, sensitivity to bone metabolism has been limited. We propose to develop advanced three-dimensional PET-MRI methods for bone and soft tissue metabolism to study the response of the tissues in the joint to changes in knee load. This work will lead to a new understanding of OA pathogenesis by revealing relationships between changes in cartilage and bone metabolism over time. This project aims to develop PET-MRI methods to sensitively track changes of OA in response to biomechanical loading. Our specific aims are to (1) Develop accurate, reproducible and dose-optimized kinetic models of dynamic 18F-NaF PET-MRI for quantitative bilateral whole joint imaging using deep learning and advanced MR coil technology, (2) Study the relationship between resting state bone metabolism and biomechanics using PET- MRI and (3) Perform a longitudinal study to assess the response of our new imaging methods to changes in joint biomechanics from gait retraining. The innovation of this work lies in the development of novel imaging techniques that simultaneously offer quantitative measures of tissue physiology in cartilage and bone using PET-MRI. The significance of this work is that we will be able to sensitively and quantitatively track changes in bone metabolism and soft tissue microstructure due to changes in biomechanical loading in the knee joint over time. This will provide new and more sensitive imaging tools to assess the responses of the joint to biomechanical interventions to treat OA such as gait retraining, bracing, or high tibial osteotomy.

项目概要 骨关节炎 (OA) 是全世界残疾的主要原因。非侵入性技术无法 量化疾病进展对 OA 发病机制的了解有限。虽然无数磁性 磁共振成像 (MRI) 方法已被提出用于 OA 成像，但对骨代谢的敏感性已被提出 受到限制。我们建议开发先进的骨骼和软组织三维 PET-MRI 方法 代谢来研究关节组织对膝关节负荷变化的反应。这项工作将带来新的 通过揭示软骨和骨变化之间的关系来了解 OA 发病机制 随着时间的推移新陈代谢。 该项目旨在开发 PET-MRI 方法，以灵敏地跟踪 OA 响应生物力学的变化 加载中。我们的具体目标是 (1) 开发准确、可重复且剂量优化的动力学模型 使用深度学习和高级 MR 进行动态 18F-NaF PET-MRI 定量双侧整体关节成像 线圈技术，（2）利用PET-研究静息态骨代谢与生物力学之间的关系 MRI 和 (3) 进行纵向研究以评估我们的新成像方法对关节变化的反应 来自步态再训练的生物力学。 这项工作的创新在于开发新颖的成像技术，同时提供 使用 PET-MRI 对软骨和骨的组织生理学进行定量测量。这项工作的意义 是我们将能够灵敏且定量地追踪骨代谢和软组织的变化 由于膝关节生物力学负荷随时间的变化而产生的微观结构。这将提供新的和 更灵敏的成像工具可评估关节对治疗 OA 的生物力学干预措施的反应 如步态再训练、支撑或胫骨高位截骨术。