SOMATOSENSORY CORTEX IN THE EXPRESSION OF AFFECTIVE SOCIAL RELATIONSHIPS

体感皮层在情感社会关系表达中的作用

• 批准号: 7562177
• 负责人: Sally P. Mendoza
• 金额: $ 8.2万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562177
• 关键词: Affective; Animals; Area; Behavior; Body Surface; Computer Retrieval of Information on Scientific Projects Database; Family; Funding; Grant; Grooming; Individual; Institution; Laboratories; Lateral; Lesion; Maps; Mediating; Monkeys; Motivation; Nature; Neocortex; Neurobiology; Neurons; Phase; Primates; Process; Regulation; Research; Research Personnel; Resources; Role; Side; Social Behavior; Somatosensory Cortex; Source; South American; Surface; System; Tactile; Tail; United States National Institutes of Health; day; grasp; member; social; social cognition; somatosensory; transmission process

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To understand the neurobiology of social behavior by tracing transmission of somatosensory information from the body surface to neuronal regions concerned with processing tactile information essential for social behavior interactions. The propensity to seek contact and to form strong positive relationships is exemplified in the extreme by the South American titi monkey. In nature and in the laboratory, these monogamous primates spend up to 90% of their day in physical contact with other members of their family group. Animals sit side-by-side with their lateral surface in close contact with another monkey. Contact between titi monkeys also includes active contact, such as grooming or grasping. A unique aspect of social contact in titi monkeys is tail-twining. Very often all members of a family group (3-5 individuals) sit in a row and combine their tails in a single twine. Using multiunit electrophysiological recording this research examines the role of several somatosensory cortical areas involved in social contact. The research involves two steps: The first is to map, in individual animals, the flow of somatosensory information from the body surface to regions of the neocortex that utilize somatosensory information in regulation of social behavior. This phase of the research relies on electophysiological recording in anesthetized monkeys. To evaluate the extent to which cortical regions are involved in social behavior, focal lesions will be performed and the effects of the lesion on social motivation and social cognition will be evaluated. These studies are unique in that they take advantage of an overt behavior, directly mediated by the somatosensory system, to examine the role of cortical mechanisms.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：通过追踪体感信息从体表到与处理社会行为交互所必需的触觉信息有关的神经元区域的传递，了解社会行为的神经生物学。 南美蒂蒂猴就是寻求接触和建立牢固的积极关系的倾向的极端例子。 在自然界和实验室中，这些一夫一妻制的灵长类动物一天中 90% 的时间都与家族中的其他成员进行身体接触。动物并排坐着，其侧面与另一只猴子紧密接触。蒂蒂猴之间的接触还包括主动接触，例如梳理毛发或抓握。蒂蒂猴社会接触的一个独特方面是尾巴缠绕。通常一个家庭的所有成员（3-5 个人）坐成一排，并将尾巴缠绕成一条线。 这项研究利用多单元电生理记录检查了参与社会接触的几个体感皮层区域的作用。该研究包括两个步骤：第一步是在个体动物中绘制体感信息从体表到新皮质区域的流动图，这些区域利用体感信息来调节社会行为。这一阶段的研究依赖于麻醉猴子的电生理记录。为了评估皮质区域参与社会行为的程度，将进行局灶性损伤，并评估损伤对社会动机和社会认知的影响。这些研究的独特之处在于，它们利用体感系统直接介导的明显行为来检查皮质机制的作用。