Mentorship in Biobehavioral Mechanisms of Avoidant/Restrictive Food Intake Disorder

回避/限制性食物摄入障碍的生物行为机制的指导

基本信息

批准号：
10783916
负责人：
JENNIFER JOANNE THOMAS
金额：
$ 18.69万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-05 至 2028-08-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10783916
关键词：
Adult Affect Amygdaloid structure Anisotropy Authorship Award Behavior Therapy Body Weight decreased Brain Brain imaging Child Choking Chronic Clinical Clinical Research Clinical Trials Design Corticospinal Tracts Cues Data Dedications Dependence Diffusion Magnetic Resonance Imaging Discipline Doctor of Philosophy Eating Disorders Ecological momentary assessment Environment Etiology Food Foundations Fright Functional Magnetic Resonance Imaging Functional disorder Funding Future General Hospitals Goals Grant Hormones Hunger Hyperactivity Hypothalamic structure Impairment Incubators Infrastructure Institution Interdisciplinary Study Laboratories Leadership Link Maintenance Malnutrition Maps Massachusetts Mentors Mentorship Mid-Career Clinical Scientist Award (K24)National Institute of Mental Health Negative Valence Neurobiology Neurocognitive Deficit Neurosecretory Systems Paper Pathway interactions Patient Care Pattern Perception Phenotype Psychiatry Psychology Publications Publishing Research Research Domain Criteria Research Personnel Resources Sensory Disorders Somatosensory Cortex Strategic Planning Structure Symptoms Taste Perception Techniques Texture Time Training Vomiting Weight avoidant restrictive food intake disorder biobehavior brain abnormalities career career development dietary supplements digital mental health early satiety experience feeding food avoidance food restriction functional disability gray matter innovation interest median forebrain bundle medical schools mid-career faculty multidisciplinary multimodal neuroimaging multimodality neuromechanism next generation novel patient oriented research programs psychosocial response restrictive eating skills stria terminalis white matter

项目摘要

PROJECT SUMMARY/ABSTRACT The applicant, Jennifer J. Thomas, Ph.D., is the Co-Director of the Eating Disorders Clinical and Research Program at Massachusetts General Hospital and Associate Professor of Psychiatry at Harvard Medical School. Over the last decade Dr. Thomas’s research has focused on the pathophysiology and treatment of feeding and eating disorders, particularly the newly recognized avoidant/restrictive food intake disorder (ARFID). Her successful mentoring experience, publication record, and current funding demonstrate her commitment and passion for patient-oriented research and provide an excellent foundation to accomplish the goals and objectives of the proposed K24 Award. Dr. Thomas’s career development goals will enable her to (1) deepen her expertise in multimodal neuroimaging techniques (integrating structural, functional, and diffusion MRI) to enhance her multidisciplinary collaborations and ability to provide translational mentorship; (2) create a sustainable infrastructure for continued research mentorship of diverse scholars to develop their own unique expertise within ARFID that will extend beyond her laboratory and beyond the K24 period; and (3) bring together her two lines of research (on behavioral treatment of ARFID and neurobiology of ARFID) to develop new treatments that modify target neural mechanisms using advanced clinical trial designs. The proposed award will enable Dr. Thomas to redistribute her effort to 30% mentorship; 60% research; and 10% patient care. Dr. Thomas will further establish a patient-oriented research program that uses innovative multidisciplinary techniques to investigate the neurobiology underlying avoidant and restrictive eating, and that provides an ideal environment to develop future leaders in clinical research across disciplines. The training environment is outstanding in terms of didactic resources and availability of techniques to assess cross-disciplinary endpoints. Importantly, Dr. Thomas has a strong commitment from Psychology and Psychiatry leadership, and a cadre of multidisciplinary collaborators and senior advisors, who have enthusiastically endorsed her research program, mentoring, and K24 proposal. The specific research aims of the application are based on a recently funded R01 investigating the link between hormones, brain function and clinical features in adults with ARFID. Important new directions under the auspices of this award will feature multimodal neuroimaging, including assessment of brain structure (gray matter volume and white matter connectivity) and its relationship with functional brain abnormalities and clinical features. In the long-term, this K24 award will build capacity in the next generation of scholars to advance research in biobehavioral mechanisms of feeding and eating disorders.

项目概要/摘要申请人詹妮弗·J·托马斯博士是饮食失调临床和研究联合主任马萨诸塞州总医院项目和哈佛医学院精神病学副教授。在过去的十年中，托马斯博士的研究重点是喂养和喂养的病理生理学和治疗。饮食失调，特别是新近认识的回避/限制性食物摄入障碍（ARFID）。成功的指导经验、发表记录和当前资金证明了她的承诺和对以患者为中心的研究充满热情，并为实现目标和目标提供良好的基础拟议的 K24 奖的职业发展目标将使她能够 (1) 加深她的专业知识。多模式神经影像技术（整合结构、功能和扩散 MRI）以增强她的能力多学科合作和提供转化指导的能力；（2）创建可持续的为不同学者提供持续研究指导的基础设施，以发展他们自己独特的专业知识 ARFID 将扩展到她的实验室和 K24 时期之外；(3) 将她的两条产品线结合在一起；研究（ARFID 的行为治疗和 ARFID 的神经生物学）开发新的治疗方法拟议的奖项将使托马斯博士能够利用先进的临床试验设计来瞄准神经机制。托马斯博士将把她的精力重新分配给 30% 的指导；以及 10% 的患者护理。以患者为导向的研究计划，使用创新的多学科技术来调查神经生物学是回避和限制性饮食的基础，这为未来的发展提供了理想的环境跨学科临床研究的领导者在教学方面的培训环境非常出色。重要的是，托马斯博士拥有评估跨学科终点的资源和技术。心理学和精神病学领导层以及多学科合作者的坚定承诺和高级顾问，他们热情支持她的研究计划、指导和 K24 提案。该应用程序的具体研究目标基于最近资助的 R01，该研究调查了两者之间的联系 ARFID 成人的激素、大脑功能和临床特征的重要新方向。该奖项的特色是多模式神经影像，包括大脑结构评估（灰质体积和白质连接）及其与功能性大脑异常和临床特征的关系。从长远来看，这个 K24 奖项将培养下一代学者的能力，以推进以下领域的研究：喂养和饮食失调的生物行为机制。