Developmental Core- Pilot Projects, Full Projects, Biostat Core and Outreach Prog
发展核心 - 试点项目、完整项目、Biostat 核心和外展计划
基本信息
- 批准号:7896560
- 负责人:
- 金额:$ 82.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:21 year oldAccountingAddressAdultAdvertisingAffinityAlcohol consumptionAreaAwardBasic ScienceBehaviorBehavioral SciencesBindingBioinformaticsBiological AssayBiological MarkersBiometryBiostatistics CoreBlood specimenBody mass indexBody of uterusBreastBromidesCD44 geneCancer CenterCancer ControlCancer EtiologyCarbohydratesCase-Control StudiesCause of DeathCell LineCervical Cancer ScreeningCessation of lifeClinicClinicalClinical ResearchClinical TrialsCollaborationsCollectionColorectal CancerCombined Modality TherapyCommitCommunicationCommunitiesCommunity HealthComplexComprehensive Cancer CenterConfidence IntervalsConsultationsContraceptive methodsContrast MediaCoupledCyclodextrinsDataData AnalysesData FilesDatabasesDevelopmentDevelopment PlansDiabetes MellitusDiagnosisDiscipline of obstetricsDoctor of PhilosophyDoseDrug FormulationsEducation and OutreachEducational workshopElectronic MailEndometrial CarcinomaEnsureEnzymesEpidemiologistExcipientsFacultyFamily history ofFamily memberFeedbackFoundationsFundingFutureGenetic PolymorphismGlucosamineGoalsGrowthGynecologicGynecologic OncologyGynecologyHabitsHealthHealth Care CostsHealth PersonnelHealth behaviorHealthcareHispanicsHistologicHormone replacement therapyHospitalsHumanHuman PapillomavirusHuman ResourcesImmunoassayIn VitroIndividualInfertilityInstitutionInsulinInsulin ResistanceInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IIInterviewIronLaboratoriesLeadLengthLifeLinear ModelsLinkLogistic RegressionsLogisticsMagnetic Resonance ImagingMalignant Epithelial CellMalignant NeoplasmsMalignant neoplasm of cervix uteriMarketingMeasurementMeasuresMediatingMedicalMedical StudentsMedicineMentorsMethodologyModelingModificationNeeds AssessmentNeoplasmsNewly DiagnosedNewsletterNonsense-Mediated DecayOdds RatioOutcomeOvarian CarcinomaParticipantPathway interactionsPatientsPhosphorylationPhosphorylation SitePhysical activityPhysiciansPilot ProjectsPopulation SciencesPopulation StudyPreventionProcessPublic HealthPublished CommentPuerto RicanPuerto RicoQuality ControlRNARNA SplicingRecording of previous eventsReportingReproductive HistoryResearchResearch DesignResearch InfrastructureResearch PersonnelResearch Project GrantsResearch ProposalsResearch TrainingResourcesRetrievalRiskRisk FactorsRisk ReductionRoleRotationSample SizeSamplingScienceScientistScreening for Ovarian CancerScreening procedureSeriesSerumSiteSmokeSmokerSmokingSocietiesSolubilitySomatomedinsStagingStatistical MethodsStudentsSurvival AnalysisSystemTissue SampleTobaccoTobacco useToxic effectTrainingTraining ProgramsTranslational ResearchTreatment ProtocolsUnderrepresented MinorityUnited StatesUniversitiesUniversity of Texas M D Anderson Cancer CenterUpdateUterine CancerVaccinationVariantWaterWeightWomanXenograft ModelXenograft procedureYeastsabstractingadiponectinanticancer researchaptameraqueousbasecancer health disparitycancer preventioncancer riskcareercareer developmentcervical cancer preventioncommunity based participatory researchcommunity organizationscost effectivenessdata managementdata modelingdesigndissemination researchdrinkingexperiencegenetic epidemiologyhealth disparityhealth organizationhigh risk drinkingimprovedindexinginsulin sensitivityinterestinvestigator trainingmalignant breast neoplasmmortalityneoplasm registrynext generationnoveloutreachoutreach programpre-clinicalprogramsreduce tobacco usereproductiveresearch clinical testingresearch studysmoking cessationsmoking prevalencestoichiometrysuccesstheoriestobacco controltreatment effectvirtual
项目摘要
[For the resubmission, research projects that received high (non-competitive) scores on the summary
statement were eliminated as suggested by the PSC (Table 47).] Four research projects, which include career
development plans (following References in each individual proposal [and in Appendix D]), are included in this
application. Three projects are continuations from the previous U54 award. [These projects have been
presented to the PSC Committee on an annual basis for feedback. All comments for revision have
been incorporated into the projects.]
In addition to the projects included on this application, funding is available for 2 pre-pilots during the 1st year
and 1 pre-pilot during the 2nd year. During the 3rd year, funding is available for 1 pilot project. During the 4th
year, funding is available for 3 full projects, 7 pilot projects or a combination of full, pilot and pre-pilot projects
for up to 2 years. All projects will undergo a thorough IAC review process to be evaluated on their potential to
expand into a larger project under the U54 mechanism and to compete for external funding (See Section 7).
A description of each full and pilot project is included following this introduction. In addition to the research
projects, this application includes a Cancer Training Program, a Cancer Outreach Program, and support cores
as described in the RFA. The Outreach Program is the continuation of a 2-year Pilot Program that started late
in the previous funding cycle.]
8.4 Solicitation of New Projects and Programs
One of the main objectives of this Partnership is to facilitate the growth of independently-funded research at
the MSI. To achieve this goal, aggressive advertising'and marketing strategies are needed to solicit the best
proposals with an emphasis on building the foundation and infrastructure of the UPRCCC. A number of
mechanisms will be used to solicit faculty from both institutions to begin collaborating including: 1) Partnership
and UPR Websites; 2) Campus Presentations; 3) MSI Office of Sponsored Research; 4)"email; 5) Email
Newsletters; and 6) Virtual Community.
Title: Pilot Project A: Pilot Case-Comparison Study of Insulin Resistance, Adiponectin and
Endometrial Cancer in Puerto Rico
ABSTRACT
Cancer of the uterine corpus is the most common gynecologic malignancy in the United States, with 40,100
new cases and 7,470 cancer-related deaths estimated for 2008. Similarly, in Puerto Rico endometrial cancer
is the most common gynecologic malignancy, and the third leading cause of cancer in women behind breast
and colorectal cancer. In the year 2003, there were 321 new cases of endometrial cancer reported to the
Puerto Rico Cancer Registry, accounting for 6% of all cancers in women. Recent observations suggest that
new pathways need to be considered, including evidence for a possible role of insulin and the insulin-like
growth factor system. We will conduct a case-comparison hospital-based pilot study to assess the role of
insulin resistance and adiponectin, a biomarker of insulin resistance, as risk factors for endometrial cancer
among Puerto Rican women. One hundred women (21 years and older) with a newly diagnosed, histologically
confirmed primary endometrial cancer will be selected at the Gynecologic Oncology clinic of the Department of
Obstetrics and Gynecology at the University of Puerto Rico Medical Science Campus (UPR-MSC) and
compared to 100 women selected among attendees to two Obstetrics and Gynecology clinics at the UPRMSC.
Participants will undergo a face-to-face interview in which the following is collected: demographic
information, smoking and drinking habits, weight history, personal and family medical history, reproductive and
menstrual history, history of contraception and hormone replacement therapy, history of infertility, and levels of
physical activity. In addition, women will undergo anthropometric measurements and collection of blood
samples for measurements of insulin resistance. Insulin resistance (IR) will be measured using the quantitative
insulin sensitivity check index (QUICKI). In addition, serum adiponectin levels, which correlate with insulin
resistance, will be measured using a commercially available quantitative sandwich enzyme-linked
immunoassay (ELISA). Univariate and multivariate unconditional logistic regression models will be used to
assess the association of endometrial cancer with insulin resistance and serum adiponectin. The odds ratio
(OR) and its 95% confidence intervals will be used to estimate the strength of the association between IR and
other factors of interest and endometrial cancer.
TITLE: Training the Next Generation of Hispanic Cancer Researchers
ABSTRACT
Early recruitment of underrepresented minorities to biomedical and health research training is essential to
ensure that society's diversity is reflected in those professions. The objective of this proposal is to strengthen
its partners' capabilities to contribute to significant increases in the participation of underrepresented minorities
in nationally competitive cancer clinical and basic research. The University of Puerto Rico (UPR) and the
University of Texas M. D. Anderson Cancer Center (MDACC) will continue to develop a comprehensive
pipeline program from undergraduates to postgraduates that will increase the number of Hispanic students
knowledgeable and committed to careers in cancer research and cancer medicine. The overall goal of this
project is to encourage Hispanic science and medical students to pursue careers in cancer research and
medicine and populate the faculty ranks at the UPR so as to strengthen cancer research at the University of
Puerto Rico. The University of Puerto Rico (UPR) is conducting the training program with MDACC in several
areas - biomedical and clinical research, didactics, enrichment experiences, M.D./PhD. training, postgraduate
clinical training, training in cancer prevention and health disparities, and career development. The desired
outcome will be achieved through a coordinated series of didactic and research experiences and enrichment
activities that include on-campus cancer research at University of Puerto Rico Comprehensive Cancer Center
(UPRCCC) during the academic year and summer research and year-round rotations to MDACC. The program
draws upon the strengths of both institutions and brings benefits to both.
TITLE: Puerto Rico Community Cancer Control Outreach Program
ABSTRACT
Cancer is the second leading cause of death among Hispanics in the US.(1) Despite the overall decline in
cancer mortality over the last decade, Hispanics continue to experience disparities for certain cancers.<2) Breast
and cervical cancer and tobacco-related cancers are among these.'113|4) Although smoking prevalence is lower
in Puerto Rico (PR) compared to the US, tobacco exerts a tremendous public health burden, with 11.5% of all
deaths and 10% of all health care costs in PR are attributable to smoking.(4> Among Puerto Rican women living
in PR, breast cancer is the most commonly diagnosed neoplasm (35% of all cancers) and the leading cause of
cancer deaths (15% of total).(9) Cervical cancer is the 4th most commonly diagnosed neoplasm in PR women,
accounting for 4% of all newly diagnosed cancers, and 2.4% of all cancer-related deaths.(9)
The purpose of the Puerto Rico Community Cancer Control Outreach Program (CCCOP) is to modify and
sustain health behavior through the development of comprehensive, sustainable partnerships for cancer
control outreach, education, research, and training in Puerto Rico (PR). Specifically, the purpose of the
CCCOP is to decrease tobacco use, increase vaccination against Human Papilloma Virus (HPV), and increase
breast and cervical cancer screening. Program components of the CCCOP will build upon collaborations,
infrastructure, network development, and outreach successes achieved in the Outreach Pilot Project. The
specific aims of the CCCOP are to: 1. Maintain, strengthen, and further develop a cancer control outreach
network that will build upon existing relationships and develop new collaborations among the University of
Puerto Rico Comprehensive Cancer Center (UPRCCC), The University of Texas M. D. Anderson Cancer
Center (MDACC), and key Puerto Rican community and health organizations; 2. Conduct a community
assessment of needs and resources for breast and cervical cancer (BCCS) prevention and screening, tobacco
control, and the elimination of disparities related to these cancers and behaviors; 3. Develop health care
provider and community organization capacity to implement and sustain culturally competent cancer control
outreach and education programs to address disparities in breast and cervical cancers and tobacco control; 4.
Provide active mentoring and career development opportunities to U54 researchers and community partners to
build capacity in cancer control and community-based participatory research; and, 5. Evaluate the impact of
the CCCOP on increasing breast and cervical cancer screening, increasing HPV vaccination, and reducing
tobacco use in PR.
The proposed project provides benefits to both UPRCCC and MDACC as each partner brings unique expertise
to the partnership. The CCCOP also includes major career development components to prepare cancer
disparities researcher at both UPRCCC and MDACC.
TITLE: Biostatistics and Bioinformatics Core
ABSTRACT
Rigorous application .of statistical methods and theory ensures that research will be conducted efficiently and
increases the likelihood that useful data will be collected and correctly interpreted. The purpose of the
Biostatistics and Bioinformatics Core (BBC) is to provide professional expertise in Biostatistics and
Bioinformatics for all research studies within the Partnership. The investigators will have a close communication
with the BBC at different stages of the projects, such as: study design, sampling design, sample size, random
assignment, determination of statistical power, data description, data modeling, data management, quality
control, database creation, keeping track of the database, merging files, updating files, data editing and filing,
and retrieval of missing data. In addition, to improve our communication with the investigators, the BBC is
planning to organize different workshops related with the statistical needs for every research studies,
particularly with regression modeling (linear, logistic, multilevel), survival analysis, clinical trials, sample size,
and power determination. Also, the BBC personnel will be involved in the assessment of new statistical
methodologies in cancer research, particularly in microarray data analysis (McLachlan, et al, 2003) and genetic
epidemiology (Suarez et al, 2007).
[对于重新提交,在摘要中获得了高(非竞争)分数的研究项目
如PSC所建议(表47)所建议的。]四个研究项目,其中包括职业
开发计划(每个单独建议中的参考文献[和附录D])包括在此中
应用。三个项目是以前的U54奖。 [这些项目已经
每年向PSC委员会提交反馈。所有修订的评论都有
被整合到项目中。]
除了本申请中包括的项目外,第一年还可以为2个前巡回演出提供资金
和1个在第二年的前小腿。在第三年内,可以为1个试点项目提供资金。在第四
一年,可用于3个完整项目,7个试点项目或完整的飞行员和前驾驶项目的组合资金
最多2年。所有项目都将经历彻底的IAC审查过程,以评估其潜力
在U54机制下扩展到一个较大的项目,并争夺外部资金(请参阅第7节)。
此介绍之后,包括每个完整和试点项目的描述。除了研究
项目,该应用程序包括癌症培训计划,癌症外展计划和支持核心
如RFA中所述。外展计划是一项为期两年的试点计划的延续,该计划迟到了
在上一个资金周期中。]
8.4征求新项目和计划
该伙伴关系的主要目标之一是促进独立资助的研究的增长
MSI。为了实现这一目标,需要积极的广告和营销策略来征求最佳
强调UPRCCC的基础和基础设施的建议。许多
机制将用于从两个机构开始合作的教师,包括:1)合作
和UPR网站; 2)校园演讲; 3)MSI赞助研究办公室; 4)“电子邮件; 5)电子邮件
新闻通讯;和6)虚拟社区。
标题:试点项目A:胰岛素抵抗,脂联素和
波多黎各的子宫内膜癌
抽象的
子宫癌是美国最常见的妇科恶性肿瘤,有40,100
新病例和2008年估计的7,470例与癌症相关的死亡。同样,在波多黎各子宫内膜癌中
是最常见的妇科恶性肿瘤,也是女性癌症的第三主要原因
和结直肠癌。在2003年,有321例子宫内膜癌病例向
波多黎各癌症登记处,占女性所有癌症的6%。最近的观察表明
需要考虑新的途径,包括胰岛素和类似胰岛素的可能作用的证据
生长因子系统。我们将进行一项病例比较医院的试点研究,以评估
胰岛素抵抗和脂联素是胰岛素抵抗的生物标志物,作为子宫内膜癌的危险因素
在波多黎各妇女中。一百名妇女(21岁及以上)有一个新诊断,组织学上
确认的原发子宫内膜癌将在该系的妇科肿瘤学诊所中选择
波多黎各大学医学校园(UPR-MSC)和
相比之下,在UPRMSC,在参与者中被选为两个妇产科诊所的100名妇女。
参与者将接受面对面的面试,其中收集以下内容:人口统计
信息,吸烟和饮酒习惯,体重历史,个人和家族病史,生殖和
月经病史,避孕史和激素替代疗法,不育症史和水平
体育锻炼。此外,女性将接受人体测量和血液的收集
用于测量胰岛素抵抗的样品。胰岛素抵抗(IR)将使用定量测量
胰岛素灵敏度检查指数(QUICKI)。此外,血清脂联素水平与胰岛素相关
电阻将使用商业可用的定量三明治酶连接来测量
免疫测定法(ELISA)。单变量和多元无条件逻辑回归模型将用于
评估子宫内膜癌与胰岛素抵抗和血清脂联素的关联。优势比
(OR)及其95%的置信区间将用于估计IR和IR之间关联的强度
感兴趣的其他因素和子宫内膜癌。
标题:培训下一代西班牙癌症研究人员
抽象的
早期招募代表性不足的少数群体接受生物医学和健康研究培训对于
确保社会的多样性反映在这些职业中。该提议的目的是加强
其合作伙伴的能力有助于大幅度增加代表性不足的少数群体的参与
在全国竞争性癌症临床和基础研究中。波多黎各大学(UPR)和
德克萨斯大学M. D.安德森癌症中心(MDACC)将继续发展全面
从本科生到研究生的管道计划将增加西班牙裔学生的数量
知识渊博,并致力于癌症研究和癌症医学的职业。总体目标
项目是为了鼓励西班牙裔科学和医学生从事癌症研究的职业和
医学和教师在UPR中排名,以加强大学的癌症研究
波多黎各。波多黎各大学(UPR)正在与MDACC进行培训计划
领域 - 生物医学和临床研究,教学,富集经验,医学博士/phd。培训,研究生
临床培训,预防癌症和健康差异的培训以及职业发展。想要的
结局将通过协调的一系列教学和研究经验和丰富来实现
包括波多黎各大学综合癌症中心的校园癌症研究的活动
(UPRCCC)在学年和夏季研究以及向MDACC的全年轮换中。该程序
借鉴了这两个机构的优势,并带来了两者的利益。
标题:波多黎各社区癌症控制外展计划
抽象的
癌症是美国西班牙裔人中第二大死亡原因。(1)尽管总体下降了
癌症死亡率在过去十年中,西班牙裔继续存在某些癌症的差异。<2)乳房
其中包括宫颈癌和与烟草有关的癌症。
与美国相比,在波多黎各(PR)中,烟草施加了巨大的公共卫生负担,其中11.5%
PR中的死亡和所有医疗保健费用的10%归因于吸烟。(4>在波多黎各人居住
在PR中,乳腺癌是最常见的肿瘤(占所有癌症的35%),也是主要原因
癌症死亡(占总数的15%)。(9)宫颈癌是PR妇女中最常见的肿瘤中第四位最常见的
占所有新诊断的癌症的4%,占所有与癌症相关的死亡的2.4%。(9)
波多黎各社区癌症控制外展计划(CCCOP)的目的是修改和
通过建立癌症的全面,可持续的伙伴关系来维持健康行为
波多黎各(PR)的控制外展,教育,研究和培训。具体而言,
CCCOP将减少烟草使用,增加针对人乳头瘤病毒(HPV)的疫苗接种,并增加
乳腺癌和宫颈癌筛查。 CCCOP的程序组件将基于协作,
外展试点项目中取得的基础设施,网络开发和推广成功。这
CCCOP的具体目标是:1。维护,增强和进一步发展癌症控制外展
网络将建立现有关系并在大学之间发展新的合作
德克萨斯大学M. D. Anderson癌症的波多黎各综合癌症中心(UPRCCC)
中心(MDACC)和主要的波多黎各社区和卫生组织; 2。进行社区
评估乳房和宫颈癌(BCC)预防和筛查的需求和资源,烟草
控制,消除与这些癌症和行为有关的差异; 3。发展医疗保健
提供者和社区组织实施和维持具有文化胜任癌症控制的能力
宣传和教育计划,以解决乳房和宫颈癌和烟草控制的差异; 4。
为U54研究人员和社区合作伙伴提供积极的指导和职业发展机会
在癌症控制和基于社区的参与性研究中建立能力; 5。评估
CCCOP在增加乳腺癌和宫颈癌筛查,增加HPV疫苗接种并减少
PR中的烟草使用。
拟议的项目为UPRCCC和MDACC提供了好处,因为每个合作伙伴都带来了独特的专业知识
与伙伴关系。 CCCOP还包括准备癌症的主要职业发展组成部分
UPRCCC和MDACC的差异研究人员。
标题:生物统计学和生物信息学核心
抽象的
严格应用统计方法和理论可确保将有效进行研究
增加了收集和正确解释有用数据的可能性。目的
生物统计学和生物信息学核心(BBC)是提供生物统计学和
伙伴关系中所有研究的生物信息学。调查人员将进行密切的沟通
BBC处于项目的不同阶段,例如:研究设计,抽样设计,样本量,随机
分配,确定统计能力,数据描述,数据建模,数据管理,质量
控制,数据库创建,跟踪数据库,合并文件,更新文件,数据编辑和归档,
并检索丢失的数据。此外,为了改善我们与调查人员的沟通,英国广播公司是
计划组织与每项研究的统计需求有关的不同研讨会,
特别是通过回归建模(线性,逻辑,多级),生存分析,临床试验,样本量,
和电力决定。此外,BBC人员将参与新统计的评估
癌症研究的方法论,特别是微阵列数据分析(McLachlan等,2003)和遗传学
流行病学(Suarez等,2007)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RAYMOND N. DUBOIS其他文献
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{{ truncateString('RAYMOND N. DUBOIS', 18)}}的其他基金
(PQA1)The Molecular Mechanisms Underlying Effects of Aspirin on Colorectal Cancer
(PQA1)阿司匹林对结直肠癌作用的分子机制
- 批准号:
8685705 - 财政年份:2014
- 资助金额:
$ 82.68万 - 项目类别:
(PQA1)The Molecular Mechanisms Underlying Effects of Aspirin on Colorectal Cancer
(PQA1)阿司匹林对结直肠癌作用的分子机制
- 批准号:
8851542 - 财政年份:2014
- 资助金额:
$ 82.68万 - 项目类别:
(PQA1)The Molecular Mechanisms Underlying Effects of Aspirin on Colorectal Cancer
(PQA1)阿司匹林对结直肠癌作用的分子机制
- 批准号:
9246071 - 财政年份:2014
- 资助金额:
$ 82.68万 - 项目类别:
Medical University of South Carolina - Cancer Center Support Grant
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