The Dynamics of Hippocampal-parietal Correlations

海马-顶叶关联的动力学

• 批准号: 7339851
• 负责人: Yuri Alexander Dabaghian
• 金额: $ 5.8万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7339851
• 关键词: Algorithms; Animals; Auditory; Back; Behavior; Brain; Brain Part; Brain region; Cells; Characteristics; Code; Complex; Correlation Studies; Data; Development; Environment; Eye Movements; Fire - disasters; Gastric Parietal Cells; Goals; Hippocampus (Brain); Laboratories; Lead; Location; Modality; Nature; Neocortex; Neurons; Numbers; Parietal; Parietal Lobe; Pathway interactions; Pattern; Personal Satisfaction; Physiology; Positioning Attribute; Primates; Process; Property; Pulvinar structure; Rattus; Relative (related person); Running; Sensory; Shapes; Software Tools; Space Perception; Specificity; Statistical Data Interpretation; Stroke; System; Tactile; Techniques; Testing; Time; Visual; Work; base; entorhinal cortex; environmental change; expectation; receptive field; relating to nervous system; research study; response; superior colliculus Corpora quadrigemina

spaceprovided) Spatial perception is a highly complex hierarchical problem. There are several parts of the brain that directly participate in spatial processing and code for different kinds of spatial reference frames. These regions work together to produce a complete, consistent representation of the environment. The goal of this study is to better understand the relationships and possible interactions between the egocentric (relative to animal's body) spatial reference frame in the parietal cortex and the allocentric (relative to the world) frame in the hippocampus, and to look for "signatures" in the activity of either region that mark transitions between alternative spatial frames in the other region. I plan to collect data simultaneously from large numbers of parietal and hippocampal neurons of a rat running on a track with variable shape to study the properties of firing activity in these regions and their responses to the changing geometry of the track. I plan to test the hypothesis that firing activity in parietal cortex is correlated with firing activity in CA1. In addition, I will work on mastering and extending a set of software tools based on the adaptive filtering algorithm used in Dr. Frank's laboratory, which allows accurate description of real time dynamics of neural spiking activity.

太空保护） 空间感知是一个高度复杂的分层问题。大脑的几部分直接 参与不同类型的空间参考帧的空间处理和代码。这些地区有效 共同产生对环境的完整，一致的表示。这项研究的目的是 更好地了解以自我为中心的关系和可能的相互作用（相对于动物的动物 主体）顶叶皮层中的空间参考框架和同类中心（相对于世界）框架 海马，并在标记在两个区域的活动中寻找“签名” 其他区域中的替代空间帧。我计划同时收集大量数据 大鼠的顶叶和海马神经元在轨道上奔跑，形状可变，以研究的特性 这些区域的发射活动及其对轨道几何形状的反应。我打算测试 假设壁皮层中的发射活性与CA1的发射活性相关。此外，我会工作 掌握和扩展一组基于Dr.自适应过滤算法的软件工具 弗兰克的实验室，可以准确描述神经尖峰活动的实时动态。

项目成果

Topological Schemas of Memory Spaces.

• DOI: 10.3389/fncom.2018.00027
• 发表时间: 2018
• 期刊: Frontiers in computational neuroscience
• 影响因子: 3.2
• 作者: Babichev A;Dabaghian YA
• 通讯作者: Dabaghian YA

Gamma Synchronization Influences Map Formation Time in a Topological Model of Spatial Learning.

• DOI: 10.1371/journal.pcbi.1005114
• 发表时间: 2016-09
• 期刊: PLoS computational biology
• 影响因子: 4.3
• 作者: Basso E;Arai M;Dabaghian Y
• 通讯作者: Dabaghian Y