Component A: BD-STEPS Core at the NC Center for Birth Defects Research and Prevention

组件 A：北卡罗来纳州出生缺陷研究和预防中心的 BD-STEPS 核心

• 批准号: 10765328
• 负责人: Tania A. Desrosiers
• 金额: $ 60万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10765328
• 关键词: Component; BD; STEPS; Core; NC

Project Abstract Component A: BD-STEPS Core at the NC Center for Birth Defects Research and Prevention Birth defects are a leading cause of infant mortality and childhood morbidity, yet the etiology of most cases is unknown. Established in 2002 with funding from the CDC, the North Carolina Center for Birth Defects Research and Prevention (NCCBDRP) has been a major contributor to the National Birth Defects Prevention Study (NBDPS) and Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS). The next phase of BD-STEPS will continue to build on these important multi-site, population-based case-control studies to identify novel epidemiologic and genetic risk factors for major structural birth defects that can be translated into prevention strategies. The NCCBDRP's Specific Aims are to (1) Implement the BD-STEPS Core protocol in North Carolina including: (a) Utilize the existing state-wide, population-based birth defects surveillance system in NC to actively ascertain at least 150 cases per year among livebirths, stillbirths and elective abortions with a study-eligible birth defect in the demographically diverse 33-county study area; (b) Utilize birth certificates to identify an eligible population-based sample of approximately 100 control infants per year born in the same study area; (c) Conduct clinical case review and classification by clinical geneticist and pediatric cardiologist using abstracted medical records; (d) Partner with CDC's central interviewing contractor to facilitate NC participation in the core interview and online occupational survey; (e) Conduct supplemental data collection about reportable infections before and during pregnancy; (f) Conduct supplemental biospecimen collection of residual newborn blood spots; (2) Establish a unique data resource for investigating prescription medication use during pregnancy and birth defects by linking BD-STEPS and NBDPS participants in NC with health insurance claims records from NC Medicaid and Blue Cross Blue Shield NC; (3) Establish a unique biospecimen resource for investigating prenatal environmental exposures and birth defects by collecting shed deciduous teeth from BD-STEPS and NBDPS participants in NC; (4) Leverage the NCCBDRP's well- established group of investigators and collaborators to develop innovative, high-impact studies with BD-STEPS and NBDPS data on genetics, epigenetics, and gene-exposure interactions associated with birth defects, and epidemiologic risk factors for birth defects including medication use during pregnancy, maternal chronic and infectious disease, and key social determinants of health such as individual- and neighborhood-level socioeconomic factors, acculturation, employment and workplace conditions, and environmental factors; (5) Produce at least seven NC-led manuscripts for publication in high-impact journals using pooled data from BD- STEPS and/or NBDPS during the 3.5-year award period; and (6) Continue our long-standing, successful training program in birth defects epidemiology.

项目摘要 组件A：NC先生缺陷研究与预防中心的BD-Steps核心 出生缺陷是婴儿死亡率和儿童发病率的主要原因，但大多数病例的病因是 未知。北卡罗来纳州遗产中心的CDC资助于2002年成立 研究与预防（NCCBDRP）一直是国家预防出生缺陷的主要贡献者 研究（NBDPS）和先天缺陷研究以评估妊娠暴露（BD步骤）。下一阶段的 BD步骤将继续基于这些重要的基于人群的病例对照研究，以识别 主要结构性先天缺陷的新型流行病学和遗传危险因素，可以转化为 预防策略。 NCCBDRP的具体目的是（1）在 北卡罗来纳州包括：（a）利用现有的全州基于人口的先天缺陷监视系统 在北卡罗来纳州，在北卡罗来纳州，每年至少确定了150例。 在人口统计学多样化的33个县研究领域中，符合研究符合研究的先天缺陷； （b）利用出生证明 确定每年约有100名对照婴儿的符合条件的基于人群的样本 研究区； （c）对临床遗传学家和小儿心脏病专家进行临床病例审查和分类 使用抽象的医疗记录； （d）与CDC的中央采访承包商合作，以促进NC 参加核心面试和在线职业调查； （e）进行补充数据收集 关于怀孕前后的可报告感染； （f）进行补充的生物循环收集 残留的新生儿血斑； （2）建立用于调查处方药的独特数据资源 通过将NC的BD步骤和NBDPS参与者与健康联系起来，在怀孕和出生缺陷期间使用 NC Medicaid和Blue Cross Blue Shield NC的保险索赔记录； （3）建立一个独特的 通过收集棚屋来调查产前环境暴露和出生缺陷的生物循环资源 NC的BD步骤和NBDPS参与者的落叶牙齿； （4）利用NCCBDRP的良好 建立的研究人员和合作者小组与BD步骤开发创新的高影响力研究 以及有关遗传学，表观遗传学和基因暴露相互作用的NBDPS数据，与先天缺陷相关 出生缺陷的流行病学危险因素，包括怀孕期间使用药物治疗，孕产妇慢性和 传染病以及健康的关键社会决定因素，例如个人和邻里水平 社会经济因素，适应，就业和工作场所条件以及环境因素； （5） 使用BD-的合并数据，至少生产七个由NC领导的手稿在高影响期刊上发表 在3。5年奖励期内的步骤和/或NBDP； （6）继续我们长期以来的成功 出生缺陷的培训计划流行病学。