Advanced Vestibular Evoked Myogenic Potential (VEMP) Screening and Testing System

先进的前庭诱发肌源电位（VEMP）筛查和测试系统

• 批准号: 7394303
• 负责人: Edward Miskiel
• 金额: $ 39.93万
• 依托单位: INTELLIGENT HEARING SYSTEMS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7394303
• 关键词: Acoustic Neuroma; Address; Adult; Affect; Age; Air; Auditory Evoked Potentials; Bone Conduction; Brain Stem Infarctions; Cartoons; Child; Clinical; Clinical Research; Clinical Trials; Computers; Conductive hearing loss; Data; Data Analyses; Data Quality; Data Set; Detection; Development; Devices; Diagnosis; Diagnostic; Ear; Electromyography; Evaluation; Feedback; Fistula; Functional disorder; Hearing; Individual; Inferior; Lead; Learning Disabilities; Lesion; Marketing; Measurement; Measures; Meniere' s Disease; Methods; Monitor; Multiple Sclerosis; Muscle; Pathway interactions; Patient Monitoring; Patients; Phase; Play; Positive Test Result; Procedures; Protocols documentation; Psychological reinforcement; Public Health; Purpose; Rate; Reading; Reporting; Research; Rotation; Saccule structure; Screening procedure; Standardization; Standards of Weights and Measures; Stimulus; Syndrome; System; Techniques; Testing; Time; Vestibular Nerve; Vestibular Neuronitis; Work; bone; computer monitor; cranium; data acquisition; improved; innovation; novel; otoconia; ototoxicity; response; software systems; visual feedback

DESCRIPTION (provided by applicant): The purpose of the project is to develop an advanced Vestibular Evoked Myogenic Potential (VEMP) screening and testing device. VEMP testing has been recognized as an indirect measure of the functional integrity of the saccule, a portion of the otoliths, the inferior vestibular nerve or other central connections of the saccule. VEMPs are currently acquired using standard Auditory Evoked Potential (AEP) systems which do not provide adequate controls over background EMG activity required to record consistent and valid VEMP responses. The proposed system will be made available either as a VEMP specific module within SmartEP, an AEP system manufactured by Intelligent Hearing Systems, integrating hearing and vestibular assessment, or as a compact portable VEMP device to be used for vestibular screening, testing, ototoxicity monitoring and other related applications. During Phase I, a VEMP module incorporating background EMG monitoring and patient feedback with video display reinforcement for testing children was developed and tested. Chained-Stimuli and CLAD high stimulation rate testing techniques were also successfully applied to VEMP testing. Acquisition and data analysis parameters were also optimized. During Phase II, a comprehensive clinical trial will be conducted to obtain normative data from 300 subjects. A computer controlled skull tap stimulator and bone vibrator headband will also be developed to facilitate VEMP testing using these techniques. The proposed device will have a direct impact on public health by standardizing the acquisition of VEMP responses, which provide a unique and objective test of saccule function, in an integrated testing module. VEMP testing has emerged as an important and valid procedure that detects the functional integrity of the saccule and the inferior vestibular nerve. The use of the proposed VEMP system is expected to greatly improve the clinical utility and data quality of VEMP testing. As such, the proposed work will greatly impact public health by developing better VEMP testing systems.

描述（由申请人提供）：该项目的目的是开发先进的前庭诱发肌源电位（VEMP）筛查和测试设备。 VEMP 测试已被认为是球囊、耳石的一部分、下前庭神经或球囊的其他中枢连接的功能完整性的间接测量。目前使用标准听觉诱发电位 (AEP) 系统获取 VEMP，该系统无法对记录一致且有效的 VEMP 响应所需的背景肌电图活动提供足够的控制。拟议的系统将作为 SmartEP 中的 VEMP 特定模块提供，SmartEP 是由智能听力系统公司制造的 AEP 系统，集成听力和前庭评估，或者作为紧凑型便携式 VEMP 设备，用于前庭筛查、测试、耳毒性监测和其他相关应用程序。在第一阶段，开发并测试了一个 VEMP 模块，该模块结合了背景肌电图监测和患者反馈以及用于测试儿童的视频显示强化。 Chained-Stimuli 和 CLAD 高刺激率测试技术也成功应用于 VEMP 测试。采集和数据分析参数也得到了优化。在第二阶段，将进行一项全面的临床试验，以获得 300 名受试者的规范数据。还将开发计算机控制的颅骨敲击刺激器和骨振动器头带，以方便使用这些技术进行 VEMP 测试。拟议的设备将通过标准化 VEMP 响应的获取对公共健康产生直接影响，该响应在集成测试模块中提供独特且客观的球囊功能测试。 VEMP 测试已成为检测球囊和下前庭神经功能完整性的重要且有效的程序。所提出的 VEMP 系统的使用预计将大大提高 VEMP 测试的临床实用性和数据质量。因此，拟议的工作将通过开发更好的 VEMP 测试系统来极大地影响公共健康。