3/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center

3/3 佛罗里达州-加利福尼亚州癌症研究、教育和参与 (CaRE2) 健康公平中心

基本信息

批准号：
10762314
负责人：
Chanita A. Hughes-Halbert
金额：
$ 114.53万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-20 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10762314
关键词：
Address Advocate African African American American Award Back Benchmarking Bioinformatics Biological Biological Models Biomedical Research Black American Black Populations Black race California Cancer Center Cancer Control Cancer Model Cancer Patient Caribbean region Caring Catchment Area Censuses Central American Communities Community Outreach Complex Comprehensive Cancer Center Cultural Diversity Development Disparity Doctor of Philosophy Education Educational Materials Effectiveness Evaluation Extramural Activities Florida Fostering Funding Goals Grant Health Health Disparities Research Heterogeneity Hispanic Incidence Individual Infrastructure Institution Latino Latino Population Latinx Latinx population Leadership Location Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of pancreas Malignant neoplasm of prostate Mentors Methodology Methods Mexican Americans Minority Minority Groups Outcome Pilot Projects Population Population Heterogeneity Postbaccalaureate Postdoctoral Fellow Process Publications Publishing Reporting Research Research Infrastructure Research Personnel Research Project Grants Research Training Resource Sharing Resources Scientist Series South American Specimen Students Tissue Model Training Training and Education Translational Research US State Underrepresented Minority Underrepresented Students Underserved Population United States Universities University of Southern California Norris Cancer Center Use Effectiveness Work anticancer research cancer health disparity cancer prevention career development community partnership disparity reduction drug development education research genetic makeup genome resource health disparity populations health equity improved improved outcome innovation innovative technologies meetings member minority communities minority patient minority trainee mortality novel anticancer drug outreach patient population podcast programs repository social determinants success tool translational cancer research understudied cancer

项目摘要

SUMMARY – OVERALL COMPONENT The Florida-California Cancer Research, Education & Engagement (CaRE2) Health Equity is proposed by the University of Florida (UF), Florida A&M University (FAMU) and the University of Southern California-Norris Comprehensive Cancer Center (USC-NCCC) to eliminate cancer health disparities in Florida, California and nationally. The long term goals of the CaRE2 center are to reduce cancer disparities in Blacks and Latinos, to train and increase the pool of underrepresented Black and Latino scientists conducting health disparity research, to increase research capacity at FAMU, and to increase cancer disparity research at UF and USC-NCCC. The bi-coastal location offers access to uniquely diverse populations of Blacks and Latinos, facilitating in an unprecedented way, the study of cancer disparities in these incredibly heterogeneous populations. Specifically, the center will focus on studying relevant issues and serving the needs of: (1) Black subpopulations, including American-born, African-born and Caribbean-born Blacks; and (2) Latino subpopulations including Mexican- Americans, Caribbean Latinos, Central and South Americans. This triad brings together investigators and institutions in the two US states that currently have the highest cancer incidence and mortality. The main scientific focus of the center is translational disparities research among heterogeneous minority populations focusing on cancers known for high mortality. We propose to coalesce expertise, infrastructure and share resources in support of 6 innovative translational research projects focused on understanding the biological basis of disparities in Black and Latino populations, capturing the wide heterogeneity within these two groups, with two foundational projects focusing on pancreas cancer (one full, one pilot) and one full project focusing on prostate cancer (Aim 1). Under the leadership of the Research Education Core, we propose to train 100 Black and Latino investigators, including students and early stage investigators (ESI), in translational cancer health disparity research (Aim 2). Existing community partnerships in the Outreach Core will be leveraged to disseminate findings in the Black and Latino community, educate about pancreas and prostate cancer, and improve participation in biomedical research (Aim 3). Finally, the Planning and Evaluation Core will implement a systematic planning and evaluation plan to improve Center effectiveness using innovative strategies (Aim 4). All research projects will be facilitated and enriched by resources and approaches provided by the Tissue Modeling Core and Bioinformatics, Statistical and Methodological Core. All CaRE2 Center’s activities will be centralized and overseen by the Administrative Core. The FAMU-UF-USC partnership is ideally suited to achieve these aims. Both UF and FAMU have worked closely together addressing cancer disparities in Florida Blacks for the last 4 years. USC-NCCC provides complementary and synergistic expertise in cancer disparities research, research training for the Latino population, and expertise in developing culturally-sensitive tools to reduce cancer disparities among Latinos.

摘要 - 整体组件佛罗里达 - 加利福尼亚癌症研究，教育与参与（CARE2）健康公平是由佛罗里达大学（UF），佛罗里达州农工大学（FAMU）和南加州 - 纳里斯大学综合癌症中心（USC-NCCC）消除佛罗里达州，加利福尼亚和全国。 Care2中心的长期目标是将黑人和拉丁美洲裔的癌症分布减少到训练并增加代表性不足的黑人和拉丁裔科学家的池，从事健康差异研究，提高FAMU的研究能力，并增加UF和USC-NCCC的癌症差异研究。双沿岸的位置提供了独特的黑人和拉丁美洲人种群的访问权限，并支持前所未有的方式，这些令人难以置信的异质种群中癌症差异的研究。具体来说，该中心将着重于研究相关问题并满足以下需求：（1）黑人亚群，包括美国出生，非洲出生和加勒比海的黑人；（2）拉丁裔亚人群，包括墨西哥 - 美国人，加勒比拉丁美洲人，中美洲和南美人。这个三合会汇集了调查人员和美国两个州目前癌症事件和死亡率最高的机构。主要科学该中心的重点是在异质少数群体中的翻译差异研究，重点是癌症以高死亡率而闻名。我们建议合并专业知识，基础设施并共享资源支持6个创新的翻译研究项目，重点是了解黑人和拉丁裔种群的差异，捕获了这两组内的广泛异质性，有两个重点关注胰腺癌（一个完整的飞行员）的基础项目和一个专注于前列腺的完整项目癌症（目标1）。在研究教育核心的领导下，我们建议培训100个黑人和拉丁裔调查人员，包括学生和早期调查人员（ESI），在翻译的癌症健康差异中研究（目标2）。外展核心中的现有社区伙伴关系将被利用以传播发现在黑人和拉丁裔社区中，对胰腺和前列腺癌进行教育，并改善参与生物医学研究（AIM 3）。最后，计划和评估核心将实施系统的计划，并使用创新策略提高中心有效性的评估计划（AIM 4）。所有研究项目都将是由组织建模核心和生物信息学提供的资源和方法促进和丰富，统计和方法论核心。所有Care2中心的活动将由行政核心。 FAMU-UF-USC合作伙伴关系非常适合实现这些目标。 UF和FAMU 在过去的四年中，一直紧密合作解决佛罗里达黑人的癌症分布。 USC-NCCC 提供癌症分布研究，拉丁裔研究培训的完整和协同专业知识人口，以及开发对文化敏感工具的专业知识，以减少拉丁美洲裔之间的癌症分布。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Empathic communication in dignity therapy: Feasibility of measurement and descriptive findings.

DOI：
10.1017/s1478951521001188
发表时间：
2022-06
期刊：
PALLIATIVE & SUPPORTIVE CARE
影响因子：
2.2
作者：
Bylund, Carma L.;Taylor, Greenberry;Mroz, Emily;Wilkie, Diana J.;Yao, Yingwei;Emanuel, Linda;Fitchett, George;Handzo, George;Chochinov, Harvey Max;Bluck, Susan
通讯作者：
Bluck, Susan

Synthesis, characterization, and anticancer evaluation of 1,3-bistetrahydrofuran-2yl-5-FU as a potential agent for pancreatic cancer.

DOI：
10.1186/s12885-022-10449-y
发表时间：
2022-12-22
期刊：
BMC cancer
影响因子：
3.8
作者：
通讯作者：

Enhancing African American Participation in Biospecimens: A Case in Point for Pancreatic Cancer.

DOI：
10.1158/1538-7755.disp20-po-236
发表时间：
2020-12
期刊：
Cancer health disparities
影响因子：
0
作者：
Behar-Horenstein L;Warren RC;Setiawan VW;Perkins C;Schmittgen TD
通讯作者：
Schmittgen TD

Review of genetic and pharmacogenetic differences in cytotoxic and targeted therapies for pancreatic cancer in African Americans.

DOI：
10.1016/j.jnma.2023.01.008
发表时间：
2023-04
期刊：
JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
影响因子：
3.3
作者：
Telisnor, Guettchina;DeRemer, David L.;Frimpong, Esther;Agyare, Edward;Allen, John;Ricks-Santi, Luisel;Han, Bo;George, Thomas;Rogers, Sherise C.
通讯作者：
Rogers, Sherise C.

CLOCK'ing differences in DNA methylation signatures to understand the molecular etiology of lung cancer.