Translational Research Center in Lung Cancer Disparities (TRACER)

肺癌差异转化研究中心 (TRACER)

• 批准号: 10290159
• 负责人: Chanita A. Hughes-Halbert
• 金额: $ 118.36万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10290159
• 关键词: Address; African American; Automobile Driving; Bioinformatics; Biological; Biological Markers; Biometry; Cancer Center; Cells; Center for Translational Science Activities; Chronic; City of Hope Comprehensive Cancer Center; Clinical; Collaborations; Collection; Communication; Communities; Community Participation; Complex; Data; Development; Diagnostic; Disease; Early Diagnosis; Exposure to; Fostering; Funding; Future; Genetic Markers; Geographic Locations; Goals; Health; Individual; Infrastructure; Intention; Intervention; Leadership; Link; Malignant Neoplasms; Malignant neoplasm of lung; Massey Cancer Center at the Virginia Commonwealth University; Medical; Molecular Genetics; Morbidity - disease rate; National Cancer Institute; Neighborhoods; Outcome; Outcomes Research; Pathology; Pathway interactions; Prevention; Preventive; Psychosocial Stress; Research; Research Design; Research Methodology; Research Personnel; Research Priority; Research Project Grants; Risk; Risk Factors; Science; Site; Smoking; Smoking Behavior; Societies; South Carolina; Stress; Structure; System; Therapeutic; Therapeutic Intervention; Training; Translating; Translational Research; Universities; Violence; Vision; base; cancer health disparity; career development; community engagement; education research; ethnic minority population; health equity; inter-institutional; interdisciplinary collaboration; lung cancer prevention; medically underserved population; mortality; next generation; novel; patient engagement; precision medicine; programs; racial and ethnic; racial discrimination; racial disparity; racial minority; research data dissemination; social; social capital; social determinants; socioeconomics; stressor; symposium; translational study

OVERALL: PROJECT SUMMARY Lung cancer continues to be one of the leading causes of morbidity and mortality among racial/ethnic minorities and individuals from other medically underserved groups. Racial minorities and individuals from other medically underserved groups have greater exposure to socioeconomic, financial, and other types of stressors (e.g., racial discrimination, structural stress because of low social capital and neighborhood violence) that can increase their risk for smoking and make it more difficult to quit. Chronic exposure to stress can trigger and disrupt biological pathways that are important to smoking behaviors and increase risk for lung cancer and other diseases. Therefore, the overarching goal and vision for the Translational Research Center in Lung Cancer Disparities (TRACER) is to address racial disparities in lung cancer morbidity and mortality by developing more precise strategies for lung cancer prevention and early detection. To accomplish this, TRACER will (1) discover cancer- driving biological mechanisms leading to racial disparities in lung cancer morbidity and mortality and analyze these mechanisms within the context of individual, social, and environmental determinants of health; (2) translate research findings into novel prevention, diagnostic, and therapeutic interventions; (3) develop an integrated inter- institutional partnership that promotes transdisciplinary research and leverages the distinct capabilities at each partner site to successfully obtain a P50 Cancer Disparities SPORE; and (4) promote bi-directional communications between AA/Black communities and investigators regarding research priorities, the development of culturally appropriate strategies for community engagement and participation in research, and the dissemination of education and research outcomes. The translational research and related training, patient and community engagement, and biospecimen collection activities in TRACER will focus explicitly on addressing racial disparities in lung cancer morbidity and mortality in order to fulfill a critical need to develop precision strategies for lung cancer prevention and early detection.

总体：项目摘要 肺癌仍然是种族/族裔少数民族中发病和死亡率的主要原因之一 以及来自其他医学欠缺群体的个人。种族少数群体和其他医学上的个人 服务不足的群体更容易接触社会经济，财务和其他类型的压力源（例如种族 歧视，由于社会资本和邻里暴力较低而导致结构性压力）可以增加他们的 冒着吸烟的风险，使戒烟变得更加困难。长期暴露于压力会触发和破坏生物学 对吸烟行为至关重要的途径并增加患肺癌和其他疾病的风险。 因此，肺癌差异转化研究中心的总体目标和愿景 （示踪剂）是通过开发更精确的肺癌发病率和死亡率的种族差异 预防肺癌和早期检测的策略。为此，示踪剂将（1）发现癌症 - 驱动生物学机制导致肺癌发病率和死亡率的种族差异并进行分析 这些机制在个人，社会和环境决定因素的背景下； （2）翻译 研究新的预防，诊断和治疗性干预措施的结果； （3）开发一个综合的间 促进跨学科研究并利用每种独特能力的机构合作伙伴关系 合作伙伴站点成功获得P50癌差异孢子； （4）促进双向 AA/黑人社区与研究人员之间有关研究重点的沟通， 制定适当的社区参与和参与研究的策略， 传播教育和研究成果。翻译研究和相关培训，病人 以及社区参与以及示踪剂中的生物循环收集活动将明确专注于解决 肺癌发病率和死亡率中的种族差异，以满足发展精度的关键需求 预防肺癌和早期检测的策略。