Expansion of Macaque Breeding runs at the New Iberia Research Center

新伊比利亚研究中心扩大猕猴繁育规模

• 批准号: 10761902
• 负责人: Francois J Villinger
• 金额: $ 399.91万
• 依托单位: RAGIN' CAJUN FACILITIES, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-12 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10761902
• 关键词: 4 year old; Acute; Air; Animals; Area; Award; Back; Birth Rate; Breeding; COVID test; COVID-19 pandemic; China; Circulation; Climate; Colorectal; Electricity; Foundations; Funding; Future; Grouping; Growth; HIV; HIV/AIDS; Heating; Housing; Laboratories; Live Birth; Longevity; Louisiana; Macaca; Macaca mulatta; Maintenance; Monkeys; Mucous Membrane; National Institute of Allergy and Infectious Disease; Pan Genus; Pathogenesis; Play; Primates; Research; Research Personnel; Rodent; Role; Running; Signal Transduction; Site; Suspensions; Testing; Texas; Therapeutic; United States National Institutes of Health; Universities; Vaccines; Vagina; Viral; Water; biosafety level 3 facility; cohort; cost; design; experience; imaging capabilities; microbicide; nonhuman primate; offspring; palliate; prevent; programs; social

University of Louisiana at Lafayette C06 Expansion of Macaque Breeding capacity at the New Iberia Research Center Abstract: As part of its expansion of its HIV/AIDS research program, the New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette (UL Lafayette) proposes to add macaque breeding capacity by the construction of 2 multi-run housing buildings complete with roofing, electricity, water, heating and air circulation for an added capacity of 1600 macaque breeders + offsprings via the Ragin Cajun Facilities, Inc. Foundation. NIRC has experienced exponential growth in the past 6 years, playing a critical role in the SARS-CoV2 pandemic while maintaining a vigorous HIV research program in support of collaborators whose laboratories were shut down. As part of this growth, NIRC has expanded its nonhuman primate (NHP) breeding and cohorts, from 6,400 to >10,000 NHPs, now the largest primate center in the US. The recent suspension of primate export from China and the limitations on NHP transport in cargo, have created an acute and monumental shortage of research NHPs, markedly amplified by their heavy use to test COVID vaccines and therapies. This has doubled and tripled animal acquisition costs, which will largely limit primate based research for academic investigators for the next decade and beyond. In efforts to palliate this gap in supply, NIRC has, and continues to expand NHP breeding and research housing, in addition to ongoing renovation of laboratory space and the construction of a BSL-3 facility regrouping rodents, NHPs and labs. The ongoing increase in breeder and research space has been the conversion of space originally used for chimpanzees into monkey social and research (quad cages) housing, and the construction of 2 new multi-run housing buildings supported by a C06 award obtained in 2021 (projected completion and occupancy date in late 2023). NIRC currently has ~1400 2-4 year old rhesus macaques future breeders slated to occupy this space, and given an annual live birth rate of >1000 rhesus macaques, NIRC has to expand such housing option further, via the construction of 2 additional identical units via this proposal. Of note, there will be space for 3 more such units for future expansion in the same area. This type of building has been specifically designed and extensively tested for macaque housing/breeding at a facility in Texas, attesting to the adequacy, ease of maintenance and longevity of such construction in southern climates. Each building unit will comprise 20 indoor/outdoor runs able to accommodate up to 20 breeder animals each for a total capacity of ~800 breeders and their offsprings. This expansion is critical to accommodate the rapidly increasing research programs at NIRC as well as the support of NIAID VRC and SVEU HIV/AIDS focused programs. NIRC supports many both onsite and collaborative programs on lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to signal cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. Many of these programs are experiencing delays due to NHP and space shortages, which are holding back the scientific expansion of NIRC and the support of HIV/AIDS NIH funded research.

路易斯安那大学拉斐特分校 C06 扩大新伊比利亚研究中心的猕猴繁殖能力 抽象的： 作为艾滋病毒/艾滋病研究计划扩展的一部分，新伊比利亚研究中心 (NIRC) 位于 路易斯安那大学拉斐特分校 (UL Lafayette) 提议通过 建造 2 栋多栋住宅楼，配备屋顶、电力、水、暖气和空气循环 通过 Ragin Cajun Facilities, Inc. 基金会增加 1600 只猕猴饲养者及其后代的饲养能力。 NIRC 在过去 6 年中经历了指数级增长，在 SARS-CoV2 大流行中发挥了关键作用 同时维持强有力的艾滋病毒研究计划，以支持实验室被关闭的合作者 向下。作为这一增长的一部分，NIRC 扩大了非人类灵长类动物 (NHP) 的繁育和群体数量，从 6,400 超过 10,000 个 NHP，目前是美国最大的灵长类动物中心。近期中国灵长类动物出口暂停 以及 NHP 货物运输的限制，造成了严重且严重的研究短缺 NHP 因其大量用于测试新冠疫苗和疗法而得到显着放大。这已经增加了一倍和三倍 动物获取成本，这将在很大程度上限制学术研究人员下一步基于灵长类动物的研究 十年及以后。为了缓解这一供应缺口，NIRC 已经并将继续扩大 NHP 育种 和研究住房，以及正在进行的实验室空间翻新和 BSL-3 的建设 重组啮齿动物、NHP 和实验室的设施。育种和研究空间的不断增加 将最初用于黑猩猩的空间转变为猴子社交和研究（四笼）住房， 并在 2021 年获得 C06 奖项的支持下建造 2 座新的多用途住宅楼（预计 竣工并入住日期为 2023 年底）。 NIRC 目前拥有约 1400 只 2-4 岁的恒河猴未来 饲养员计划占据这个空间，鉴于恒河猴的年活产率超过 1000 只，NIRC 已 为了进一步扩大这种住房选择，通过该提案建造另外 2 个相同的单元。的 请注意，同一区域还可以容纳 3 个这样的单元，以便将来进行扩展。这种类型的建筑有 在德克萨斯州的一家设施中针对猕猴饲养/繁殖进行了专门设计和广泛测试，证明 此类建筑在南方气候条件下的充分性、易于维护性和使用寿命。每栋楼 该单元将包括 20 个室内/室外跑道，每个跑道可容纳多达 20 只种畜，总容量 大约 800 名饲养员及其后代。这种扩展对于适应快速增长的研究至关重要 NIRC 项目以及 NIAID VRC 和 SVEU HIV/AIDS 重点项目的支持。 NIRC 支持 许多关于慢病毒发病机制的现场和合作项目均由最先进的成像技术支持 能力包括全身信号细胞分析方法、旨在治愈艾滋病毒的治疗方法、 以及一项广泛的计划，通过保护性实验疫苗、阴道和 结直肠杀菌剂。由于 NHP 和空间短缺，许多这些项目都出现了延误， 这些都阻碍了 NIRC 的科学扩展以及 NIH 资助的艾滋病毒/艾滋病研究的支持。