Expansion of Macaque Breeding runs at the New Iberia Research Center

新伊比利亚研究中心扩大猕猴繁育规模

• 批准号: 10761902
• 负责人: Francois J Villinger
• 金额: $ 399.91万
• 依托单位: RAGIN' CAJUN FACILITIES, INC.
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-12 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10761902
• 关键词: 4 year old; Acute; Air; Animals; Area; Award; Back; Birth Rate; Breeding; COVID test; COVID-19 pandemic; China; Circulation; Climate; Colorectal; Electricity; Foundations; Funding; Future; Grouping; Growth; HIV; HIV/AIDS; Heating; Housing; Laboratories; Live Birth; Longevity; Louisiana; Macaca; Macaca mulatta; Maintenance; Monkeys; Mucous Membrane; National Institute of Allergy and Infectious Disease; Pan Genus; Pathogenesis; Play; Primates; Research; Research Personnel; Rodent; Role; Running; Signal Transduction; Site; Suspensions; Testing; Texas; Therapeutic; United States National Institutes of Health; Universities; Vaccines; Vagina; Viral; Water; biosafety level 3 facility; cohort; cost; design; experience; imaging capabilities; microbicide; nonhuman primate; offspring; palliate; prevent; programs; social

University of Louisiana at Lafayette C06 Expansion of Macaque Breeding capacity at the New Iberia Research Center Abstract: As part of its expansion of its HIV/AIDS research program, the New Iberia Research Center (NIRC) at the University of Louisiana at Lafayette (UL Lafayette) proposes to add macaque breeding capacity by the construction of 2 multi-run housing buildings complete with roofing, electricity, water, heating and air circulation for an added capacity of 1600 macaque breeders + offsprings via the Ragin Cajun Facilities, Inc. Foundation. NIRC has experienced exponential growth in the past 6 years, playing a critical role in the SARS-CoV2 pandemic while maintaining a vigorous HIV research program in support of collaborators whose laboratories were shut down. As part of this growth, NIRC has expanded its nonhuman primate (NHP) breeding and cohorts, from 6,400 to >10,000 NHPs, now the largest primate center in the US. The recent suspension of primate export from China and the limitations on NHP transport in cargo, have created an acute and monumental shortage of research NHPs, markedly amplified by their heavy use to test COVID vaccines and therapies. This has doubled and tripled animal acquisition costs, which will largely limit primate based research for academic investigators for the next decade and beyond. In efforts to palliate this gap in supply, NIRC has, and continues to expand NHP breeding and research housing, in addition to ongoing renovation of laboratory space and the construction of a BSL-3 facility regrouping rodents, NHPs and labs. The ongoing increase in breeder and research space has been the conversion of space originally used for chimpanzees into monkey social and research (quad cages) housing, and the construction of 2 new multi-run housing buildings supported by a C06 award obtained in 2021 (projected completion and occupancy date in late 2023). NIRC currently has ~1400 2-4 year old rhesus macaques future breeders slated to occupy this space, and given an annual live birth rate of >1000 rhesus macaques, NIRC has to expand such housing option further, via the construction of 2 additional identical units via this proposal. Of note, there will be space for 3 more such units for future expansion in the same area. This type of building has been specifically designed and extensively tested for macaque housing/breeding at a facility in Texas, attesting to the adequacy, ease of maintenance and longevity of such construction in southern climates. Each building unit will comprise 20 indoor/outdoor runs able to accommodate up to 20 breeder animals each for a total capacity of ~800 breeders and their offsprings. This expansion is critical to accommodate the rapidly increasing research programs at NIRC as well as the support of NIAID VRC and SVEU HIV/AIDS focused programs. NIRC supports many both onsite and collaborative programs on lentiviral pathogenesis supported by state of the art imaging capabilities including a whole body to signal cell analysis approach, therapeutic approaches aimed at curing HIV, and an extensive program to prevent mucosal viral acquisition via protective experimental vaccines, vaginal and colorectal microbicides. Many of these programs are experiencing delays due to NHP and space shortages, which are holding back the scientific expansion of NIRC and the support of HIV/AIDS NIH funded research.

路易斯安那大学拉斐特C06 新伊比利亚研究中心的猕猴育种能力的扩展 抽象的： 作为扩展其艾滋病毒/艾滋病研究计划的一部分，新的伊比利亚研究中心（NIRC） 路易斯安那大学拉斐特大学（UL Lafayette）建议通过 建造两座多跑房屋建筑，配有屋顶，电力，水，供暖和空气流通 通过Ragin Cajun设施Inc. Foundations增加了1600个猕猴育种者 +后代。 NIRC在过去6年中经历了指数级的增长，在SARS-COV2大流行中起着至关重要的作用 同时维持一项有力的艾滋病毒研究计划，以支持其实验室关闭的合作者 向下。作为这种增长的一部分，NIRC已将其非人类灵长类动物（NHP）育种和同伙从6,400 至> 10,000 NHP，现在是美国最大的灵长类动物中心。最近被中国出口灵长类动物 以及货物中NHP运输的局限性，造成了严重和巨大的研究短缺 NHPS明显地通过其大量使用来测试辅助疫苗和疗法。这已经翻了一番，两倍 动物获取成本将在很大程度上限制下一个学术研究者的基于灵长类动物的研究 十年及以后。为了弥补这一供应差距，NIRC拥有并继续扩大NHP育种 除了进行实验室空间的持续翻新以及BSL-3的构建外，研究住房 设施重新组合啮齿动物，NHP和实验室。育种者和研究空间的持续增加一直是 将黑猩猩最初用于猴子社会和研究（四笼）住房的空间转换， 以及由2021年获得的C06奖励支持的两座新的多跑房屋建筑的建设（预计 2023年底的完成日期）。 NIRC目前拥有〜1400 2-4岁的猕猴未来 育种者计划占据这一空间，并给出了每年的活产率> 1000恒河猕猴，nirc拥有 通过此提案，通过构建2个相同的单位，进一步扩展了这种住房选择。的 请注意，将有3个此类单元的空间，以便将来在同一区域扩展。这类建筑有 在德克萨斯州的一个设施中专门设计和广泛测试了猕猴的住房/繁殖 为了充分，在南部气候中，这种建筑的维护和寿命便利。每个建筑物 单元将包括20个室内/室外运行，可容纳多达20种育种动物 约800名育种者及其后代。这种扩展对于适应快速增加的研究至关重要 NIRC的计划以及NIAID VRC和SVEU HIV/AIDS集中的计划的支持。 NIRC支持 许多关于慢病毒发病机理的现场和协作计划，由艺术状态成像支持 功能，包括全身进行信号细胞分析方法，旨在治愈HIV的治疗方法， 以及通过保护性实验疫苗，阴道和 结直肠微生物。由于NHP和空间短缺，这些程序中的许多程序正在经历延误， 这阻碍了NIRC的科学扩张和艾滋病毒/艾滋病NIH资助的研究的支持。