Factors Regulating T Helper Cell Memory Differentiation

调节 T 辅助细胞记忆分化的因素

• 批准号: 6822221
• 负责人: ROBERT A SEDER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6822221
• 关键词: cell differentiation; cell population study; cytokine; developmental immunology; enzyme linked immunosorbent assay; helper T lymphocyte; immunologic memory; immunoregulation; laboratory mouse

CD4+ T cells can be segregated into distinct subsets based on their pattern of cytokine production. CD4+ T cells that secrete IFN-g are termed Th1 cells while cells that secrete IL-4, IL-5 and IL-13 are termed Th2 cells. While Th1 cells are essential in mediating protection against a variety of intracellular infections they also are mediate pro-inflammatory responses associated with a variety of autoimmune diseases. Th2 cells have a role in counter-regulating Th1 responses and are associated with allergic and asthmatic disease. These studies examine the factors, which regulate how T helper responses are sustained in vivo.

CD4+ T 细胞可以根据其细胞因子产生模式分为不同的亚群。分泌 IFN-g 的 CD4+ T 细胞称为 Th1 细胞，而分泌 IL-4、IL-5 和 IL-13 的细胞称为 Th2 细胞。虽然 Th1 细胞对于介导针对各种细胞内感染的保护至关重要，但它们也介导与各种自身免疫性疾病相关的促炎症反应。 Th2 细胞在反调节 Th1 反应中发挥作用，并与过敏和哮喘疾病相关。这些研究考察了调节 T 辅助反应在体内如何持续的因素。