Patient perspectives on primary statin nonadherence

患者对主要他汀类药物不依从的看法

基本信息

批准号：
9300650
负责人：
DERJUNG M TARN
金额：
$ 20.48万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-15 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9300650
关键词：
Address Adherence Adverse effects Age American Attitude Behavior Belief California Cardiovascular Diseases Cardiovascular system Characteristics Cholesterol Clinical Data Clinical Research Cognitive Communication Comprehension Cross-Sectional Studies Data Databases Dependency Elements Eligibility Determination Evaluation Feeling Focus Groups Fright Future Goals Guidelines Health Health Care Costs Health Personnel Healthcare Healthcare Systems Hispanics Individual Industry Internet Intervention Interview Knowledge Language Latino Measures Medical Medical Records Medical Societies Methods Minority Morbidity - disease rate Motivation Myocardial Infarction Oxidoreductase Patient Preferences Patients Perception Performance Persons Pharmaceutical Preparations Pharmacology Phase Physicians Population Prevention strategy Primary Prevention Provider Public Health Reporting Research Risk Risk Factors Risk Reduction Standardization Stroke Structure Suggestion Surveys System Testing United States Universities base cardiovascular disorder risk cohort cost demographics design health belief health literacy inhibitor/antagonist medication compliance middle age mortality older patient personalized approach prevent stem

项目摘要

Project Summary Cardiovascular disease (CVD) is the United States' leading cause of morbidity, mortality, and health care costs, but proven CVD risk reduction strategies are often not fully used. Medications such as HMGCoA reductase inhibitors, commonly referred to as “statins,” can reduce CVD risks. However, up to 34% of patients never fill a newly prescribed statin (primary nonadherence), and consequently fail to reduce their CVD risk. Data about primary nonadherence are sparse. The limited data counterintuitively suggest higher rates of primary statin nonadherence in some populations at greater risk for CVD, such as blacks and Hispanics/ Latinos, but the reasons for these disparities are unknown. There is incomplete information about the interplay of patient, healthcare system and provider factors underlying primary nonadherence, and about the type and content of motivational strategies that might encourage primary statin adherence. It is crucial to accurately identify reasons for primary statin nonadherence order to ultimately help people lower their CVD risk. The long-term goal of this research agenda is to reduce CV risk by developing patient-targeted tailored interventions to promote medication adherence. This study will contribute a comprehensive understanding of the reasons that patients choose not to fill a newly prescribed statin, and patient preferences for solutions to overcome primary nonadherence. This cross-sectional study has two phases. In Phase 1, focus group and semi-structured interviews with middle-aged and older white, black, and English- and Spanish-speaking Hispanic/Latino patients will yield open-ended data exploring the range of reasons patients decide not to fill initial statin prescriptions (focusing on patient attitudes and beliefs), and solicit ideas for potential solutions to overcome these barriers. In Phase 2, we will develop and pilot-test a structured survey with a separate patient cohort (Aim 2). Cognitive interviews will be used to refine survey content and wording. Eligible study patients will be identified by querying standardized databases from a PCORnet (PCORI's National Clinical Research Network) Patient-Powered Research Network (Health eHeart) (Phase 1) and from a PCORnet Clinical Data Research Network (pScanner) and the University of California healthcare system (UC ReX) for Phases 1 and 2. The study's specific aims are to: 1) determine: a) patient attitudes, beliefs, and other factors associated with primary statin nonadherence and b) patient suggestions to overcome these barriers; and 2) develop and pilot-test English- and Spanish-language surveys to understand patient characteristics (e.g., demographics, health) related to: a) patient-reported reasons for primary statin nonadherence and b) preferred strategies to overcome primary statin nonadherence. We expect this study to provide critical preliminary information for the design and conduct of a future larger-scale survey, which will in turn inform the content of tailored patient-targeted interventions to reduce primary statin nonadherence, and ultimately reduce CVD risks.

项目概要心血管疾病 (CVD) 是美国发病率、死亡率和医疗保健的主要原因成本，但行之有效的降低 CVD 风险的策略通常没有得到充分利用，例如 HMGCoA。还原酶抑制剂（通常称为“他汀类药物”）可以降低高达 34% 的患者的 CVD 风险。切勿服用新开的他汀类药物（原发性不依从），因此无法降低 CVD 风险。关于原发性不依从性的数据很少，有限的数据违反直觉地表明，原发性不依从性的发生率较高。在一些心血管疾病风险较高的人群中，如黑人和西班牙裔，主要他汀类药物不依从/ 拉丁裔，但造成这些差异的原因尚不清楚。有关相互作用的信息不完整。原发性不依从性背后的患者、医疗保健系统和提供者因素，以及类型和可能鼓励主要他汀类药物依从性的激励策略内容至关重要。确定主要他汀类药物不依从的原因，以最终帮助人们降低 CVD 风险。该研究议程的长期目标是通过开发针对患者的定制方案来降低心血管风险这项研究将有助于全面了解药物依从性。患者选择不服用新开的他汀类药物的原因，以及患者对解决方案的偏好克服主要的不依从性这项横断面研究分为两个阶段：第一阶段、焦点小组和对中年和老年白人、黑人、英语和西班牙语人士进行半结构化访谈西班牙裔/拉丁裔患者将产生开放式数据，探索患者决定不填写的一系列原因初始他汀类药物处方（重点关注患者的态度和信念），并征求潜在解决方案的想法在第二阶段，我们将开发并试点一项单独的结构化调查。患者队列（目标 2）将用于完善调查内容和措辞。将通过查询 PCORnet（PCORI 的国家临床实验室）的标准化数据库来识别患者研究网络）患者支持的研究网络（Health eHeart）（第一阶段）和来自 PCORnet 临床数据研究网络 (pScanner) 和加州大学医疗保健系统 (UC ReX) 第 1 阶段和第 2 阶段。该研究的具体目标是： 1) 确定： a) 患者的态度、信念和其他因素与主要他汀类药物不依从有关，b) 患者克服这些障碍的建议；2) 开发并试点英语和西班牙语调查，以了解患者特征（例如，人口统计学、健康状况）与以下方面相关：a）患者报告的主要他汀类药物不依从性的原因和 b）首选我们期望这项研究能够提供关键的初步结果。为未来更大规模调查的设计和实施提供信息，从而为调查的内容提供信息量身定制的针对患者的干预措施，以减少主要他汀类药物的不依从性，并最终降低 CVD 风险。