Aging in 1000 healthy young adults: the Dunedin Study

1000 名健康年轻人的衰老：达尼丁研究

基本信息

批准号：
9503460
负责人：
AVSHALOM CASPI
金额：
$ 15.9万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-03-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9503460
关键词：
Age Age of Onset Aging Aging-Related Process Archives Asthma Basic Science Behavioral Biological Biological Aging Biological Markers Biological Process Birth Blood Cardiovascular Diseases Caring Cause of Death Childhood Chronology Cities Clinical Cognitive Consequentialism DNA Data Data Collection Data Set Dementia Deterioration Development Diagnosis Disease Drug Insurance Drug Prescriptions Economics Education Elderly Epigenetic Process Face Fertility Rates Future Genetic Genomics Goals Government Half-Life Health Heritability Human Individual Infant International Intervention Knowledge Leukocytes Life Life Cycle Stages Life Expectancy Link Longevity Longitudinal Studies Maintenance Measures Medical Methods Methylation Modeling Molecular Non-Insulin-Dependent Diabetes Mellitus Obesity Onset of illness Paper Pathogenesis Personal Attribute Personality Persons Physiological Plant Roots Policy Maker Population Prevalence Primary Health Care Protocols documentation Psychopathology Public Health Readiness Records Research Risk Risk Factors Scoring Method Smoking Social Welfare Social Work Specific qualifier value Statistical Models Surveys System Testing Tissues Translations Update Variant Work adverse outcome age related aging population base biobank body system clinical practice cohort cost disability early onset economic cost endophenotype exhaustion experience follow-up genetic profiling genome wide association study genomic signature health care service improved member middle age multidisciplinary neglect peer prevent public health relevance research and development simulation social telomere theories tool virtual young adult

项目摘要

DESCRIPTION (provided by applicant): Declining fertility rates, aging of the baby-boomers, and increasing life expectancy are leading to population aging. As the population ages, this increases the public-health burden of age-related conditions, such as cardiovascular disease, type 2 diabetes, and dementia. Treating un-prevented diseases in late life has proven costly and ineffective. It is now known that potentially preventable risk exposures and physiological causes of age-related disease emerge in childhood. This recognition lends new scientific significance to studies that have followed cohorts from childhood. It is also now known that the pathogenesis of age-related diseases involves gradually accumulating decline in organ systems, beginning in the first half of the life course. Consequently, new interventions aiming to prevent age-related diseases will have to be applied to individuals while they are yet young, before they reach midlife. Translation of basic-science geronotology discoveries into interventions for young humans is lacking because virtually nothing is known about the process of biological aging during the first half of the life course. This prompts our proposal to study the pace of biological aging from the twenties forward. We will use the Dunedin Multidisciplinary Health & Development Study, a longitudinal study of a birth cohort now entering its fifth decade. This study combines methods of demographic/economic surveys, clinical- quality health assessments, biobanking, and linkage to nationwide administrative records (health, welfare, finances). We propose to administer a full-day data-collection protocol to the 1004 living members of the birth cohort. To assess each cohort member's pace of biological aging we will: (a) measure biomarkers across multiple organ systems, and (b) statistically model correlated change in these biomarkers assessed at ages 26, 32, 38, and 45 years. We will describe individual variation in the pace of aging, plus its developmental origins, genomic signatures, functional consequences, and economic costs. We will identify attributes that set apart individuals whose bodies are months or years younger than their chronological age. The proposed work will improve knowledge by generating findings to support future interventions to slow aging, prevent age-related disease, and improve the quality of longer lives.

描述（由申请人提供）：生育率下降、婴儿潮一代的老龄化和预期寿命的增加正在导致人口老龄化。随着人口老龄化，这增加了与年龄相关的疾病（例如心血管疾病）的公共卫生负担。、2 型糖尿病和痴呆症。现已证明，治疗晚年未预防的疾病成本高昂且无效。现在已知，与年龄相关的疾病的潜在可预防风险暴露和生理原因会在儿童期出现。这一认识赋予了新的科学意义。人们从童年开始就进行了跟踪研究，现在还知道，与年龄相关的疾病的发病机制涉及从生命历程的前半段开始逐渐累积的器官系统衰退，旨在预防与年龄相关的疾病的新干预措施。必须在中年之前将基础科学老年学发现应用于年轻人的干预措施中，因为人们对前半生的生物衰老过程几乎一无所知。当然，这促使我们提出建议。研究生物学的步伐我们将使用达尼丁多学科健康与发展研究，这是一项针对现已进入第五个十年的出生群体的纵向研究。这项研究结合了人口/经济调查、临床质量健康评估、生物银行和联系的方法。我们建议对 1004 名出生队列成员进行全天数据收集，以评估每个队列成员的生物衰老速度。跨多个器官系统的生物标志物，以及（b）在 26、32、38 和 45 岁时评估的这些生物标志物的统计模型相关变化，我们将描述衰老速度的个体差异，以及其发育起源、基因组特征、功能。我们将确定那些身体比实际年龄年轻数月或数岁的人的特征，通过产生支持未来减缓衰老、预防与年龄相关的疾病和疾病的干预措施来提高知识。提高质量更长久生活。