Hispanic Alliance- Administrative Supplement-Strain-level pangenomic analyses ofvaginal Lactobacillus in a gradient of dysplasia in Hispanic women living in Puerto Rico.

西班牙裔联盟 - 行政补充 - 对生活在波多黎各的西班牙裔妇女的阴道乳酸菌在不典型增生梯度中的菌株水平全基因组分析。

• 批准号: 10727700
• 负责人: Carlos A. Luciano
• 金额: $ 26.49万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-02 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10727700
• 关键词: Academia; Address; Administrative Supplement; Adoption; Affect; Bioinformatics; Biometry; Cardiometabolic Disease; Clinical Research; Collaborations; Communicable Diseases; Communication; Communities; Community Health; Community Networks; Community Outreach; Dedications; Development; Development Plans; Disasters; Disease; Dysplasia; Emerging Communicable Diseases; Ensure; Epidemiology; Ethnic Origin; Ethnic Population; Evaluation; Foundations; Funding; Generations; Goals; Government; Health; Health Policy; Health Sciences; Healthcare; Hispanic; Hispanic Populations; Human Resources; Infrastructure; Institution; Island; Knowledge; Laboratories; Lactobacillus; Leadership; Malignant Neoplasms; Medical; Mentors; Methods; Mission; Modeling; Outcome; Participant; Pilot Projects; Population; Positioning Attribute; Process; Public Health; Puerto Rico; Research; Research Design; Research Personnel; Resources; Safety; Science; Scientist; Services; Specific qualifier value; Structure; System; Technology; Training; Training Activity; Translational Research; United States; United States National Institutes of Health; Universities; Woman; Work; biomedical informatics; career development; clinical translation; community based participatory research; community center; community engaged research; community engagement; community organizations; cyber infrastructure; data infrastructure; data warehouse; effective therapy; health care delivery; health data; hispanic community; improved; innovation; interdisciplinary collaboration; medical schools; medically underserved; next generation; programs; recruit; research and development; research facility; statistics; synergism; translational research program

Improving health care for the medically underserved, including our Hispanic population, afflicted by prevalent diseases, such as cancer, cardio-metabolic and infectious diseases, remains a major challenge. The current application is to support the development of Hispanic Alliance for Clinical & Translational Research in Puerto Rico (Alliance), which aims to build on the existing infrastructure of the Puerto Rico Clinical and Translational Research Consortia (PR-CTRC an RCMI-CTR) and the unique expertise on emerging infectious diseases and the study of disaster-related conditions and their impact on Health. The objective of the Alliance is to serve as the catalytic center to enhance the competitiveness of investigators to conduct research and obtain additional funding for clinical and translational research addressing highly prevalent diseases and those that affect the medically underserved in Puerto Rico. The long-term goal of the Alliance is to transform clinical and translational research in Hispanic populations in the Mainland and in Puerto Rico by promoting inter-disciplinary collaboration and leverage of resources to address diseases affecting Hispanic communities. Successful implementation of the Alliance will advance our fundamental knowledge of Hispanic health in this ethnic subgroup, which is increasingly represented in the U.S. mainland population. The Alliance is innovative because it will: (1) create a Hispanic-centered research hub integrating resources to support researchers in PR and national partners; (2) implement the Hispanic Real World clinical research data warehouse; and (3) establish a Community Health & Research Council comprised of diverse community partners emphasizing a community-centered, bi-directional research focus to impact health policy and ultimately improving health outcomes in our Hispanic community. The Alliance overall aims are specified below. Specific Aim 1: Enhance an island-wide infrastructure and human resource network and synergize with local and national partners to conduct clinical and translational research in Puerto Rico. Specific Aim 2: Provide professional development activities to enhance the ability of investigators to develop competitive clinical and translational research programs with emphasis on Hispanic health needs. Specific Aim 3: Facilitate the generation and dissemination of knowledge to and from the bench and the community to improve health outcomes that affect Hispanic communities in Puerto Rico and across United States. Specific Aim 4: Catalyze and sustain the integration of trans/multi/inter disciplinary collaborations to conduct clinical and translational research within and across institutions, organizations, community networks and health programs in Puerto Rico and other IDeA states.

改善医疗服务不足的人群的医疗保健，包括受疾病困扰的西班牙裔人口 癌症、心脏代谢疾病和传染病等流行病仍然是一个重大挑战。 当前的申请是为了支持西班牙临床与转化研究联盟的发展 波多黎各（联盟），旨在建立在波多黎各临床和 转化研究联盟（PR-CTRC 和 RCMI-CTR）以及新发传染病方面的独特专业知识 疾病以及与灾害相关的状况及其对健康的影响的研究。联盟的目标 是作为催化中心，增强研究者进行研究和研究的竞争力 获得额外资金用于针对高度流行疾病的临床和转化研究，以及 那些影响波多黎各医疗服务不足的人的问题。联盟的长期目标是 改变大陆和波多黎各西班牙裔人群的临床和转化研究 促进跨学科合作和利用资源来解决影响疾病的问题 西班牙裔社区。 该联盟的成功实施将提高我们对西班牙裔健康的基础知识 这个族裔亚群在美国大陆人口中所占比例越来越大。该联盟是 创新，因为它将：（1）创建一个以西班牙裔为中心的研究中心，整合资源以支持 公关研究人员和国家合作伙伴； (2)实施西班牙裔真实世界临床研究数据 仓库; (3) 建立一个由不同社区组成的社区健康与研究委员会 合作伙伴强调以社区为中心的双向研究重点，以影响卫生政策和 最终改善我们西班牙裔社区的健康状况。明确了联盟的总体目标 以下。 具体目标1：加强全岛基础设施和人力资源网络，并与当地发挥协同作用 与国家合作伙伴在波多黎各进行临床和转化研究。 具体目标2：提供专业发展活动，增强研究者的发展能力 有竞争力的临床和转化研究项目，重点关注西班牙裔的健康需求。 具体目标 3：促进知识的生成和传播 社区改善影响波多黎各和整个联合国拉美裔社区的健康结果 国家。 具体目标 4：促进和维持跨/多/跨学科合作的整合，以开展 机构、组织、社区网络和健康内部和之间的临床和转化研究 波多黎各和其他 IDeA 州的项目。